DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and nas-13

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_510549.3	Gene:	nas-13 / 185492	WormBaseID:	WBGene00003532	Length:	450	Species:	Caenorhabditis elegans

Alignment Length:	244	Identity:	79/244 - (32%)
Similarity:	119/244 - (48%)	Gaps:	44/244 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YQGDIKAHPIRTRN-----------GI-------VNQIY-HWPNRTVPYMIEDDAFADSHYREIL 76
            ::|||....:.:|:           ||       |.|.| .|....:||.|... ::.....:|.
Worm    78 FEGDIANSGLNSRSINTFFGDSPLFGIFGVQRNAVRQTYLKWEQARIPYTISSQ-YSSYSRSKIA 141

  Fly    77 RAISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGS 141
            .||....:.:|:.|.|.:..|.....::...  ||.:: :|.....|.|:     ||:||.:.|.
Worm   142 EAIEEYRKKTCIDFSPKSAGDLDYIHIVPDD--GCYSL-VGRIGGKQPVS-----LGDGCIQKGI 198

  Fly   142 IIHELLHVLGFEHQHVSQNRDQYVSIQWKNIN-------PQYNINFVNNDNSTAWHDFDEGYDYE 199
            |||||:|.:||.|:....:||:||.|.|.|:.       .:|::|.:::        ....|||.
Worm   199 IIHELMHAVGFFHEQSRADRDEYVKINWSNVEAGLQDQFDKYSLNMIDH--------LGTKYDYG 255

  Fly   200 SVMHYVPRAFSRNGQPTIVPLREGAENMGQRFYMSEKDIRKLNKMYRCP 248
            |||||.|.|||:||:|||.|:.:..| :|||...||.||.|:|.:|.||
Worm   256 SVMHYAPTAFSKNGKPTIEPIEKNVE-IGQRAGFSENDIYKINMLYNCP 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	70/203 (34%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	66/196 (34%)
nas-13	NP_510549.3	Astacin	118..304	CDD:279708	70/204 (34%)
		ZnMc_astacin_like	122..300	CDD:239807	66/195 (34%)
		ShK	367..404	CDD:279838
		ShK	414..450	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920