DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Semp1 and nas-14

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_502533.2	Gene:	nas-14 / 184247	WormBaseID:	WBGene00003533	Length:	503	Species:	Caenorhabditis elegans

Alignment Length:	247	Identity:	83/247 - (33%)
Similarity:	123/247 - (49%)	Gaps:	35/247 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YQGDIKAHPIRTRNGIVNQI---------------YH------------WPNRTVPYMIEDDAFA 68
            ::|||...|...::.|:.::               :|            ||...||||:|:....
Worm    76 FEGDIMGVPEIEKSDILKRLRDDPLLDEDEIFRKPFHSALNLVTYPDKLWPEGQVPYMLEEGMTN 140

  Fly    69 DSHYREILRAISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLG 133
            |.. ..|.:|....:..:||.|.|.|:.||....|..:...||:: ::|.....|.|:||:
Worm   141 DQR-TAIAQAFDEYKTKTCVRFVPKTDDDFDYIYVKRNVAFGCSS-YVGRAGGNQTVSLEV---- 199

  Fly   134 EGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFDEGYDY 198
            :.||..|.|.|||:|.|||.|:|...:||.:|.|...||.|....||........ ......|||
Worm   200 DKCFSKGIIAHELMHALGFFHEHSRTDRDDFVDINEDNIRPGMMRNFEKYPRKII-DSLGMPYDY 263

  Fly   199 ESVMHYVPRAFSRNGQPTIVPLREGAENMGQRFYMSEKDIRKLNKMYRCPDH 250
            ||||||...||||||:|||:| ::...::|||:.:||.|.:|:||:|:|.::
Worm   264 ESVMHYHKLAFSRNGKPTIIP-KDNEADVGQRYKLSEMDSKKVNKLYQCGEY 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	77/195 (39%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	73/189 (39%)
nas-14	NP_502533.2	Astacin	123..313	CDD:279708	77/197 (39%)
		ZnMc_astacin_like	128..309	CDD:239807	73/188 (39%)
		ShKT	380..414	CDD:214586
		ShK	468..503	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820