DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and nas-8

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_501114.2	Gene:	nas-8 / 183207	WormBaseID:	WBGene00003527	Length:	403	Species:	Caenorhabditis elegans

Alignment Length:	254	Identity:	77/254 - (30%)
Similarity:	124/254 - (48%)	Gaps:	36/254 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 FKDPELL------AG-------FYQGDIK-----------AHPIRTRNGIVNQIYHWPNRTVPYM 61
            ||:.|.|      ||       :.:|||:           :..:| |||::.....|||..:||:
Worm    66 FKNGEKLGEDHVPAGSILWKQVYKKGDIRGKAAWKLDPKNSESLR-RNGVITGTRKWPNGRIPYV 129

  Fly    62 IEDDAFADSHYREILRAISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTVHLGYRNKTQVVN 126
            |.:. :.|.....:.|:.....:.:||.|.|.|.:|.....:  .|..||.: .:|.....|.::
Worm   130 ISNQ-YNDRERAVLARSFQAYHDKTCVRFVPRTAVDNDYLYI--GKIDGCYS-DVGRAGGRQELS 190

  Fly   127 LEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHD 191
            |:     .||.:..:.||||:|.:||.|:|...:||::::|.|.||:.:....|...|.:.:.:
Worm   191 LD-----NGCLQYDTAIHELMHSVGFYHEHERWDRDEHITILWHNIDREAYDQFGKVDLAESSY- 249

  Fly   192 FDEGYDYESVMHYVPRAFSRNGQPTIVPLR-EGAENMGQRFYMSEKDIRKLNKMYRCPD 249
            :.:.|||.|:|||...|||:||..|:|..: |....:|.....|..||.|:|.||:|.|
Worm   250 YGQLYDYYSIMHYDSLAFSKNGFETMVAKQSEMTAVIGAAIDFSPIDILKMNLMYQCSD 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	63/196 (32%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	58/190 (31%)
nas-8	NP_501114.2	Astacin	119..308	CDD:279708	63/198 (32%)
		ZnMc_astacin_like	123..304	CDD:239807	58/190 (31%)
		ShK	337..372	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920