DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and nas-6

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001040902.1	Gene:	nas-6 / 181796	WormBaseID:	WBGene00003525	Length:	344	Species:	Caenorhabditis elegans

Alignment Length:	233	Identity:	76/233 - (32%)
Similarity:	115/233 - (49%)	Gaps:	27/233 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 AGFYQGDIKA----------HPIRTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREILRAISII 82
            :|.:||||..          .|: ..|.:.|:...|....:||.: |.||:.:..:.:.:|....
Worm    47 SGKFQGDIDGVDPNLLKLPEGPV-LFNALKNKQLTWEGGVIPYEM-DTAFSPNEIKILEKAFDSY 109

  Fly    83 EENSCVIF-KPATEMDFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHEL 146
            ...:|:.| |...:.|: :.:|   ||.||.: .:|.....|.::     ||.|||....|:|||
Worm   110 RRTTCIRFEKREGQTDY-LNIV---KGYGCYS-QVGRTGGKQEIS-----LGRGCFFHEIIVHEL 164

  Fly   147 LHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFD-EGYDYESVMHYVPRAFS 210
            :|.:||.|:|...:||.::.|.|.||.|.....|  :..|....|.. |.|||:|:|||...|||
Worm   165 MHSVGFWHEHSRADRDDHIKINWDNILPGMKSQF--DKISAVLQDLQGENYDYKSIMHYDSTAFS 227

  Fly   211 RNGQPTIVPLREG-AENMGQRFYMSEKDIRKLNKMYRC 247
            |||:.||..:..| .:.:|....:|..||.|:||:|.|
Worm   228 RNGRNTIETVENGFTQVIGTAMDLSPLDIVKINKLYSC 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	68/198 (34%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	65/192 (34%)
nas-6	NP_001040902.1	Astacin	80..265	CDD:279708	67/197 (34%)
		ZnMc_astacin_like	83..263	CDD:239807	65/192 (34%)
		ShK	299..334	CDD:279838
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166527
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5777
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	1	1.000	-	-		FOG0000240
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.900