DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and hch-1

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_510440.1	Gene:	hch-1 / 181564	WormBaseID:	WBGene00001828	Length:	605	Species:	Caenorhabditis elegans

Alignment Length:	213	Identity:	63/213 - (29%)
Similarity:	102/213 - (47%)	Gaps:	24/213 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 RTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREILRAISIIEENSCVIF---KPATEMDFPMAL 102
            |:....:::.:.:|   |||.|:..:..:::  .:|..::..|:.:|..|   ...:......||
Worm   124 RSMTSFLSERWSFP---VPYYIDTSSGVNTN--AVLAGVAKWEQETCARFTRLNSYSSSSRQNAL 183

  Fly   103 VITSKGLGCNTVHLGYRNKTQVVNLEIYP----LGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQ 163
            ...| |.||      |.|   :..:..:|    :|.||..:|::.||:.|.|||.|:....:||.
Worm   184 RFIS-GNGC------YSN---IGKVSRFPQDVSIGWGCTSLGTVCHEIGHALGFYHEQARYDRDD 238

  Fly   164 YVSIQWKNINPQYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQPTIVPLREGAE-NM 227
            ||||..:||...|...| ...::::..|:..||||.|||||...|||..|..||.......: .:
Worm   239 YVSILTQNIQDMYLSQF-TKQSASSMVDYGVGYDYGSVMHYDQAAFSSTGGNTIATRDPNFQATI 302

  Fly   228 GQRFYMSEKDIRKLNKMY 245
            |||...|..|::::|..|
Worm   303 GQRVAPSFADVKRINFAY 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	62/201 (31%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	60/197 (30%)
hch-1	NP_510440.1	Astacin	132..323	CDD:279708	62/205 (30%)
		ZnMc_astacin_like	135..320	CDD:239807	61/200 (31%)
		CUB	386..466	CDD:214483
		TSP1	533..565	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910