DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and nas-37

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001024413.1	Gene:	nas-37 / 181208	WormBaseID:	WBGene00003553	Length:	765	Species:	Caenorhabditis elegans

Alignment Length:	218	Identity:	63/218 - (28%)
Similarity:	97/218 - (44%)	Gaps:	34/218 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KAHPIRTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREILR-AISIIEENSCVIFKPATEMDFP 99
            :||| ..||       .|||.|:.|....   .:..:|:::| ||..:|:|.|..||   |....
Worm   115 QAHP-DPRN-------FWPNLTISYEFYG---GEETWRQLIRSAIRHVEQNVCFKFK---ENGGD 165

  Fly   100 MALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQY 164
            ...:...:|.||      :.|..:|...::..:|.||..:|.:.||.||.||..|:....:||.:
Worm   166 RDGLRYYRGNGC------WSNVGRVGGRQLVSIGYGCDSLGIVSHETLHALGLWHEQSRDDRDNF 224

  Fly   165 VSIQWKNINPQYNINF-----VNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQPTIVPLREG- 223
            :||....|......||     .|:||      ..:.||..|||||..::|:.:.....:..|:.
Worm   225 ISIVADKITRGTEGNFAKRTAANSDN------LGQPYDLGSVMHYGAKSFAYDWSSDTIKTRDWR 283

  Fly   224 -AENMGQRFYMSEKDIRKLNKMY 245
             ...:|||..:|.||.:.:|..|
Worm   284 YQNTIGQRDGLSFKDAKMINTRY 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	58/201 (29%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	55/197 (28%)
nas-37	NP_001024413.1	Astacin	122..309	CDD:279708	59/210 (28%)
		ZnMc_astacin_like	126..306	CDD:239807	55/197 (28%)
		CUB	370..455	CDD:214483
		TSP1	579..626	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020