DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and nas-38

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001359993.1	Gene:	nas-38 / 180407	WormBaseID:	WBGene00003554	Length:	727	Species:	Caenorhabditis elegans

Alignment Length:	280	Identity:	63/280 - (22%)
Similarity:	118/280 - (42%)	Gaps:	71/280 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TVFSELFKDP-------ELLAG----FYQGDIKAHPIRTRNGIV----------------NQIY- 51
            |||.::.::|       ||...    ::|||:.....:.:  |:                |.:|
Worm    60 TVFDDIQRNPNTGVHHDELAVNNADEYFQGDVDLSEQQVK--IIEDQFTQGKREKRKIGRNPLYK 122

  Fly    52 HWPNR---------TVPYMIEDDAFADSHYREILRAISIIEENSCVIFKP----ATEMDFPMALV 103
            .|..|         ::|:...         ::|..|:.:.::::|:.|:.    ...::|
Worm   123 KWDTRGPISFDYAESIPFQTR---------QKIRSAMLLWQQHTCLRFEEGGPNVDRLEF----- 173

  Fly   104 ITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQ 168
              ..|.||:: .:|....||.:::..    .||..:|.|.||:.|.||..|:....:::::::|.
Worm   174 --FDGGGCSS-FVGRVGGTQGISIST----PGCDVVGIISHEIGHALGIFHEQARPDQERHIAIN 231

  Fly   169 WKNI--NPQYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNG-QPTIVPL-REGAENMGQ 229
            :.||  :...|...|..:::   ..::..||..|||||.|..|:.:. .|||..| |.....:||
Worm   232 YNNIPLSRWNNFQAVGENHA---ETYNLPYDTGSVMHYGPYGFASDPYTPTIRTLERVQQSTIGQ 293

  Fly   230 RFYMSEKDIRKLNKMYRCPD 249
            |...|..|.:.:|..|.|.:
Worm   294 RAGPSFLDYQAINMAYGCTE 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	51/212 (24%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	48/206 (23%)
nas-38	NP_001359993.1	Astacin	122..313	CDD:366617	51/214 (24%)
		CUB	367..466	CDD:214483
		TSP1	613..658	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920