DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and dpy-31

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_001022731.1	Gene:	dpy-31 / 176014	WormBaseID:	WBGene00006592	Length:	592	Species:	Caenorhabditis elegans

Alignment Length:	305	Identity:	82/305 - (26%)
Similarity:	124/305 - (40%)	Gaps:	96/305 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 ELFKDPELLA---------------GFYQGDIKAHPIRT----------------RNGIVNQIYH 52
            |..|:|||:|               .|:||||..:|.:.                |..|.:.:..
Worm    71 ERHKNPELVAWDRKRDSVLNPEEQGKFFQGDIVLYPEQAKALYEQALTEGKTRVKRKFIGSNLRR 135

  Fly    53 W-PNRTVPYMIEDDAFADSHYREILRAISIIEEN----SCVIFKPATEMDFPMALVITSKGLGCN 112
            | .:|.:.|     ||..||.:...|.|.:..|:    :|:.|:...:.:....:|.|... ||.
Worm   136 WDASRPIIY-----AFDGSHTQREQRIIELALEHWHNITCLNFQRNDQANSGNRIVFTDVD-GCA 194

  Fly   113 TVHLGYRNKTQVVNLEIYPLGE--------GCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQW 169
            :            |:..:||||        .|.|:|.|.||:.|.|||.|:....:|||||:::|
Worm   195 S------------NVGRHPLGEEQLVSLAPECIRLGVIAHEVAHALGFWHEQSRPDRDQYVTVRW 247

  Fly   170 KNINPQYNINFVNNDNSTAWHDFDEG---YDYESVMHYVPRAFSRNGQPTIVP--LREGAENMGQ 229
            :||:......|:..|..    |.|..   |||.|:|||..:|||:......:.  :.:..:.:||
Worm   248 ENIDKDSKGQFLKEDPD----DVDNAGVPYDYGSIMHYRSKAFSKFDDLYTISTYVTDYQKTIGQ 308

  Fly   230 RFYMSEKDIRKLNKMY-------------------------RCPD 249
            |..:|..|||.:||:|                         ||||
Worm   309 RDQLSFNDIRLMNKIYCSAVCPSKLPCQRGGYTDPRRCDRCRCPD 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	66/238 (28%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	62/206 (30%)
dpy-31	NP_001022731.1	Astacin	134..327	CDD:279708	64/214 (30%)
		ZnMc_astacin_like	139..324	CDD:239807	62/206 (30%)
		CUB	383..483	CDD:214483
		TSP1	493..539	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020