DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and toh-1

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_497769.3	Gene:	toh-1 / 175491	WormBaseID:	WBGene00006591	Length:	414	Species:	Caenorhabditis elegans

Alignment Length:	223	Identity:	63/223 - (28%)
Similarity:	103/223 - (46%)	Gaps:	21/223 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KAHPIRTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREIL-RAISIIEENSCVIFKPATEMDFP 99
            |.|..| |..|..|||.|.:..:|:.|..   .|.:::.:: |.|.:.|:::|:.||...:....
Worm    55 KVHRHR-REVIAGQIYDWNSYEIPFQIWG---GDYNFQSLIRRGIRMWEDSTCLRFKENQQSRDA 115

  Fly   100 MALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQY 164
            :..|: .||..|.|.::|.....|.:     .:|..|.....:.||..|.|||.|.|...:||::
Worm   116 IRYVL-EKGDSCFTEYIGRNGGHQDI-----IIGSECAEEYVVAHETGHALGFWHTHQRPDRDRH 174

  Fly   165 VSIQWKNINPQYNINFVNNDNSTAWHDFDE------GYDYESVMHYVPRAFS-RNGQPTIVPLR- 221
            :||.|||:..:...:|:...:........:      .|||.|:|||...|.: :....||||..
Worm   175 ISINWKNVMEEATASFMPFRSMLQAFGIRQVSPRRVPYDYGSLMHYHAVAHAVKVSDFTIVPKEL 239

  Fly   222 EGAENMGQRFYMSEKDIRKLNKMYRCPD 249
            :....||.. .|:..|.:.:|.:| ||:
Worm   240 KYVTTMGTE-KMAFLDAKVINDIY-CPN 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	54/204 (26%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	51/198 (26%)
toh-1	NP_497769.3	Astacin	71..265	CDD:279708	54/204 (26%)
		ZnMc_astacin_like	73..262	CDD:239807	51/198 (26%)
		CUB	320..410	CDD:214483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820