DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and nas-25

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_495880.1	Gene:	nas-25 / 174412	WormBaseID:	WBGene00003544	Length:	399	Species:	Caenorhabditis elegans

Alignment Length:	212	Identity:	62/212 - (29%)
Similarity:	101/212 - (47%)	Gaps:	34/212 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 YHWPNRTVPYMIEDDAFADSHYREILR-AISIIEENSCVIFKPATEMDFPMALVITSKGLGCNTV 114
            |.|||.||||.:.:   ..|..::.:| ||..::..:|:.|:...|.        .|.|.....|
Worm    48 YRWPNNTVPYYVGN---VTSTIKKSVRLAIEELQAWTCIRFQNVNEK--------YSDGDSVRIV 101

  Fly   115 HLGYRNK---TQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNIN--- 173
            .||..:.   .|.:..:...|.:.|:.:|:.||||:|.:|.||.....:|::|:.|..:||:
Worm   102 DLGSCSSPIGRQQIGTQDVSLTKNCWGMGTAIHELMHAIGIEHTQSRSDRNRYLDILAQNIDNRD 166

  Fly   174 -PQYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFS-RNGQPTIVPL-REGAENMGQ---RFY 232
             |.:.:.     :...|.:. ..|||.|||||...:|| ::.:.|::|. |...|.||.   .||
Worm   167 LPNFELL-----SPRLWANL-VPYDYGSVMHYSADSFSNKDDEQTMLPKDRSFIETMGSMIPNFY 225

  Fly   233 MSEKDIRKLNKMYRCPD 249
                |..::|:.|:|.|
Worm   226 ----DFDQINQYYQCYD 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	60/208 (29%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	56/202 (28%)
nas-25	NP_495880.1	Astacin	48..236	CDD:279708	60/208 (29%)
nas-25	NP_495880.1	ZnMc_astacin_like	52..234	CDD:239807	56/202 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920