DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and Mep1b

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_032612.2	Gene:	Mep1b / 17288	MGIID:	96964	Length:	704	Species:	Mus musculus

Alignment Length:	225	Identity:	75/225 - (33%)
Similarity:	112/225 - (49%)	Gaps:	27/225 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YQGDIKAHPIRTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREILRAISIIEENSCVIFKP-AT 94
            ::||||.. ...:|.|:.....||: |:||::||....::. ..||.|.......:|:.||| :.
Mouse    51 FEGDIKLE-ANGKNSIIGDHKRWPH-TIPYVLEDSLEMNAK-GVILNAFERYRLKTCIDFKPWSG 112

  Fly    95 EMDFPMALVITSKGLGC----NTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFEHQ 155
            |.::    :...||.||    ..:|.|.:..:         :|..|.||.::.||.||.|||.|:
Mouse   113 EANY----ISVFKGSGCWSSVGNIHAGKQELS---------IGTNCDRIATVQHEFLHALGFWHE 164

  Fly   156 HVSQNRDQYVSIQWKNINP--QYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQPTIV 218
            ....:||.||.|.|..|.|  ::|.|..|:..|.:   .:..|||.|||||...||....:.|||
Mouse   165 QSRADRDDYVIIVWDRIQPGKEHNFNIYNDSVSDS---LNVPYDYTSVMHYSKTAFQNGTESTIV 226

  Fly   219 P-LREGAENMGQRFYMSEKDIRKLNKMYRC 247
            . :.|..:.:|||...|:.|:.|||::|.|
Mouse   227 TRISEFEDVIGQRMDFSDYDLLKLNQLYNC 256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	69/203 (34%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	65/197 (33%)
Mep1b	NP_032612.2	ZnMc	30..256	CDD:294052	74/223 (33%)
		Astacin	70..258	CDD:279708	69/205 (34%)
		MAM	266..430	CDD:279023
		MAM	266..428	CDD:99706
		MATH	428..587	CDD:295307
		EGF_CA	609..647	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910