DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and Mep1a

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_032611.2	Gene:	Mep1a / 17287	MGIID:	96963	Length:	760	Species:	Mus musculus

Alignment Length:	235	Identity:	82/235 - (34%)
Similarity:	119/235 - (50%)	Gaps:	24/235 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LLAG--FYQGDIKAHPIRTRNGIVNQIYHWPNRTVPYMIEDDAFADSHYREILRAISIIEENSCV 88
            |.||  .:||||...  ||||.:.:....| ...:||::.|:...::. ..||.|..:....|||
Mouse    60 LAAGLNLFQGDILLP--RTRNAMRDPSSRW-KLPIPYILADNLELNAK-GAILHAFEMFRLKSCV 120

  Fly    89 IFKPATEMDFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFE 153
            .|||   .:...:.:|..|..||.:: :|.:...|.::     :||||....:|.||:||.|||.
Mouse   121 DFKP---YEGESSYIIFQKLSGCWSM-IGDQQVGQNIS-----IGEGCDFKATIEHEILHALGFF 176

  Fly   154 HQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFDEGYDYESVMHYVPRAFSRNGQ-PTI 217
            |:....:||.||:|.|..|...|..||...|::|. .|.:..|||||:|||.|.:|::|.. |||
Mouse   177 HEQSRTDRDDYVNIWWDQIITDYEHNFNTYDDNTI-TDLNTPYDYESLMHYGPFSFNKNESIPTI 240

  Fly   218 -VPLREGAENMGQRFYMSEKDIRKLNKMYRCP------DH 250
             ..:.|....:||....|..|:.:||:||.|.      ||
Mouse   241 TTKIPEFNTIIGQLPDFSAIDLIRLNRMYNCTATHTLLDH 280

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	69/203 (34%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	65/191 (34%)
Mep1a	NP_032611.2	ZnMc	46..271	CDD:381785	79/224 (35%)
		MAM	281..444	CDD:366209	82/235 (35%)
		MATH	443..607	CDD:351761
		EGF	688..722	CDD:333761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910