DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and nas-36

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	NP_492109.2	Gene:	nas-36 / 172506	WormBaseID:	WBGene00003552	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	251	Identity:	66/251 - (26%)
Similarity:	112/251 - (44%)	Gaps:	34/251 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FLFTPTVFSELFKDPELLAGFYQGDIKAHPIRTRNGIV-NQIYHWPNRTVPYMIED--DAFADSH 71
            |||...:|....:..::|....:...|    |.|...| ::...|....:.|...:  |.:..|
Worm    96 FLFEGDIFLSRRQAVDILKALSKDKTK----RLRRSFVSDKTATWKTMPIKYRFHESIDFYTIS- 155

  Fly    72 YREILRAISIIEENSCVIFKPATEM---DFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLG 133
              :|:.||...|:::|:.|:..::.   |:    :....|.||.:: :|.....|.::     :|
Worm   156 --QIIAAIRFWEDSTCITFENVSDSPDGDY----IEFFSGQGCYSM-IGRNGGRQGIS-----IG 208

  Fly   134 EGCFRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFDE---G 195
            |.|.::|.|.||:.|.||..|:....:...||:|:...|.|.|..:|:..|:     :.|.   .
Worm   209 ESCVKMGVIEHEIGHALGLWHEQSRPDALGYVTIERDFILPSYISDFLQRDD-----EIDTLGIP 268

  Fly   196 YDYESVMHYVPRAFSRNGQPTIVPLREG--AENMGQRFYMSEKDIRKLNKMYRCPD 249
            ||..|||||...|||.:.:...|..|:.  .:.:|||..:|..|:..:|..| |.|
Worm   269 YDLGSVMHYGSTAFSVDQKSKTVVTRDSLYQQTIGQREKLSFYDVATINTAY-CKD 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	56/205 (27%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	53/199 (27%)
nas-36	NP_492109.2	Astacin	134..323	CDD:279708	56/207 (27%)
		ZnMc_astacin_like	140..320	CDD:239807	53/197 (27%)
		CUB	380..478	CDD:214483
		TSP1	510..556	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820