DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and astl3c

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_002937470.2	Gene:	astl3c / 100491451	XenbaseID:	XB-GENE-22069695	Length:	533	Species:	Xenopus tropicalis

Alignment Length:	229	Identity:	82/229 - (35%)
Similarity:	106/229 - (46%)	Gaps:	38/229 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 GDIKAHPIRTRNGIVNQIYHWPNR-----TVPYMIEDDAFADSHYREIL---RAISIIEENSCVI 89
            |||.   |.......:..|.||..     .|||:...:..||    |:.   .|:...|..:||.
Frog    77 GDIL---INIGRSATSSDYLWPKSADGTVVVPYIFSYNYSAD----ELTLFKTAMQEFETLTCVR 134

  Fly    90 FKPAT-EMDFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGCFRIGSIIHELLHVLGFE 153
            |.|.| :.||   |.|.|.| ||.:: :|.....|.|.|..|    ||...|.|.|||.|.|||.
Frog   135 FVPKTIQRDF---LNIVSNG-GCLSM-VGRNGGGQKVELASY----GCMSRGVIQHELNHALGFY 190

  Fly   154 HQHVSQNRDQYVSIQWKNINPQYNINF----VNNDNSTAWHDFDEGYDYESVMHYVPRAFSRN-G 213
            |:|:..:||.||:|..:||.|.|...|    .||....        |||.|||||....||.: .
Frog   191 HEHMRSDRDDYVTIITENIIPSYENYFSKRKTNNMGII--------YDYNSVMHYSRNTFSISPD 247

  Fly   214 QPTIVPLREGAENMGQRFYMSEKDIRKLNKMYRC 247
            :.||||..:.:..:|||..:|..||.|:.|:|:|
Frog   248 KSTIVPKPDPSIPIGQRDGLSILDILKIKKLYQC 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	77/209 (37%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	73/203 (36%)
astl3c	XP_002937470.2	ZnMc	99..281	CDD:381785	74/202 (37%)
		CUB	290..393	CDD:366096
		CUB	398..508	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681837at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020