DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Semp1 and astl3b.2

DIOPT Version :9

Sequence 1:	NP_609756.1	Gene:	Semp1 / 34914	FlyBaseID:	FBgn0028944	Length:	251	Species:	Drosophila melanogaster
Sequence 2:	XP_031746779.1	Gene:	astl3b.2 / 100491112	XenbaseID:	XB-GENE-22069683	Length:	529	Species:	Xenopus tropicalis

Alignment Length:	241	Identity:	87/241 - (36%)
Similarity:	119/241 - (49%)	Gaps:	27/241 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VFSELFK-DPELLAGFYQGDIKAHPIRTRNGIVNQIYHWPNRT-----VPYMIEDDAFAD--SHY 72
            ||:::.| :..:....|||||.....|:.......:  ||..|     |||....:..||  :.:
Frog    80 VFTQISKVNRGIRVPTYQGDILRPKGRSAMNCTECL--WPKSTDGTVIVPYNFSSNYSADQLALF 142

  Fly    73 REILRAISIIEENSCVIFKP-ATEMDFPMALVITSKGLGCNTVHLGYRNKTQVVNLEIYPLGEGC 136
            :..::.   .|..:||.|.| |.|.||   |.|.|.. ||.: .||.....|.|.|:.|    ||
Frog   143 KSTMQE---YESLTCVRFVPRANETDF---LSIVSDN-GCAS-FLGKVGGDQTVQLDSY----GC 195

  Fly   137 FRIGSIIHELLHVLGFEHQHVSQNRDQYVSIQWKNINPQYNINFVNNDNSTAWHDFDEGYDYESV 201
            ...|.|.|||.|.|||.|:....:||.||:|..:||.|.|..||...|::....:    |||.||
Frog   196 IYRGIIQHELNHALGFYHEQSRSDRDDYVTIHTENIIPGYEGNFNKADSNNLGLE----YDYSSV 256

  Fly   202 MHYVPRAFSRNGQPTIVPLREGAENMGQRFYMSEKDIRKLNKMYRC 247
            |||...|||:||..||||..:....:|||..:|..|:.|:|::|:|
Frog   257 MHYPGDAFSKNGNLTIVPKPDPTVPIGQRDGLSILDVSKINRLYQC 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Semp1	NP_609756.1	Astacin	53..249	CDD:279708	78/203 (38%)
Semp1	NP_609756.1	ZnMc_astacin_like	55..245	CDD:239807	74/197 (38%)
astl3b.2	XP_031746779.1	ZnMc_hatching_enzyme	121..302	CDD:239810	74/196 (38%)
		CUB	306..414	CDD:238001
		CUB	419..527	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D472790at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010