DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15255 and mep1a.2

DIOPT Version :9

Sequence 1:	NP_001285958.1	Gene:	CG15255 / 34913	FlyBaseID:	FBgn0028950	Length:	261	Species:	Drosophila melanogaster
Sequence 2:	NP_001122199.1	Gene:	mep1a.2 / 565535	ZFINID:	ZDB-GENE-041001-208	Length:	689	Species:	Danio rerio

Alignment Length:	266	Identity:	88/266 - (33%)
Similarity:	141/266 - (53%)	Gaps:	24/266 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSRSGIIYVLLLQVVLNSGKPLPAGVYDPEEAGGFVEGDMMLTEEQQRNLEQG---APKARNGLI 62
            |.|..:.:|||..    ....|||...:..:||...|..:.:..:.||.|.:|   ....||.:|
Zfish     4 MWRISLFFVLLAL----KACALPAQYGEDADAGELREDILEINLDSQRELFEGDIAGDPRRNAII 64

  Fly    63 NTEKRW--PGNVVVYRISDDFDTAHKKAIQTGIDTLELHTCLRFREATDEDKAYLTVTAKSGGCY 125
            :.:.||  |   :.|.::|..|...|..|...::...|.:|:.|:....| ..|::.| |..||:
Zfish    65 DEKARWQFP---IPYILTDTLDLNAKGVILQALEMYRLKSCVDFKPYEGE-STYISFT-KLDGCW 124

  Fly   126 TAVGYQGAPQEMNLEIYPLGEGCFRPGTILHEFMHALGFYHQQSSSIRDDFINVIYENIVPGKEF 190
            :.||.....|.::     :||.|.....:.||.:|||||||:||.|.|||::.:.::.|:.|||.
Zfish   125 SFVGDLKTGQNVS-----IGERCDTKAIVEHELLHALGFYHEQSRSDRDDYVKIWWDQIIEGKEH 184

  Fly   191 NFQKYADTVVTDFEVGYDYDSCLHYRPGAFSINGE----DTIVPLDSSAVIGQRVGLSSKDIDKI 251
            ||.||.|..:||....|||:|.:||||.:|:.:.:    .|.:|..:: :||||:..|:.|::::
Zfish   185 NFNKYEDDFITDLNTPYDYESIMHYRPLSFNKDPDIPTITTTIPAFNN-IIGQRLDFSALDLERL 248

  Fly   252 NIMYKC 257
            |.||:|
Zfish   249 NRMYEC 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15255	NP_001285958.1	Astacin	66..258	CDD:279708	70/198 (35%)
CG15255	NP_001285958.1	ZnMc_astacin_like	70..255	CDD:239807	64/188 (34%)
mep1a.2	NP_001122199.1	ZnMc	26..254	CDD:294052	79/238 (33%)
		Astacin	68..256	CDD:279708	70/198 (35%)
		MAM	259..423	CDD:214533
		MAM	264..423	CDD:99706
		MATH	423..579	CDD:295307
		EGF	619..653	CDD:278437
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910