DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG15255 and MEP1A

DIOPT Version :9

Sequence 1:	NP_001285958.1	Gene:	CG15255 / 34913	FlyBaseID:	FBgn0028950	Length:	261	Species:	Drosophila melanogaster
Sequence 2:	XP_011512930.1	Gene:	MEP1A / 4224	HGNCID:	7015	Length:	774	Species:	Homo sapiens

Alignment Length:	271	Identity:	85/271 - (31%)
Similarity:	142/271 - (52%)	Gaps:	48/271 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IYVLLLQVVLNSGKPLP-AGVYDPE------------EAG-GFVEGDMMLTEEQQRNLEQGAPKA 57
            :|:...|:     |.|| ..|:|.:            .|| ...:||::|            .|:
Human    45 LYIYFFQI-----KYLPEENVHDADFGEQKDISEINLAAGLDLFQGDILL------------QKS 92

  Fly    58 RNGLINTEKRW--PGNVVVYRISDDFDTAHKKAIQTGIDTLELHTCLRFREATDEDKAYLTVTAK 120
            ||||.:...||  |   :.|.::|:.....|.||....:...|.:|:.|:....| .:|: :..:
Human    93 RNGLRDPNTRWTFP---IPYILADNLGLNAKGAILYAFEMFRLKSCVDFKPYEGE-SSYI-IFQQ 152

  Fly   121 SGGCYTAVGYQGAPQEMNLEIYPLGEGCFRPGTILHEFMHALGFYHQQSSSIRDDFINVIYENIV 185
            ..||::.||.|...|.::     :|:||.....|.||.:|||||||:||.:.|||::|:.::.|:
Human   153 FDGCWSEVGDQHVGQNIS-----IGQGCAYKAIIEHEILHALGFYHEQSRTDRDDYVNIWWDQIL 212

  Fly   186 PGKEFNFQKYADTVVTDFEVGYDYDSCLHYRPGAFSINGE-DTI---VPLDSSAVIGQRVGLSSK 246
            .|.:.||..|.|:::||....|||:|.:||:|.:|:.|.. .||   :| :.:::||||:..|:.
Human   213 SGYQHNFDTYDDSLITDLNTPYDYESLMHYQPFSFNKNASVPTITAKIP-EFNSIIGQRLDFSAI 276

  Fly   247 DIDKINIMYKC 257
            |::::|.||.|
Human   277 DLERLNRMYNC 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG15255	NP_001285958.1	Astacin	66..258	CDD:279708	68/198 (34%)
CG15255	NP_001285958.1	ZnMc_astacin_like	70..255	CDD:239807	62/188 (33%)
MEP1A	XP_011512930.1	ZnMc_meprin	58..287	CDD:239809	79/251 (31%)
		Astacin	101..289	CDD:279708	68/198 (34%)
		MAM	292..459	CDD:214533
		MAM	297..459	CDD:99706
		MATH_Meprin_Alpha	459..622	CDD:239752
		EGF_CA	700..738	CDD:238011
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3714
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8634
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10127
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X245
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910