DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek3 and TRIL

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_055632.2 Gene:TRIL / 9865 HGNCID:22200 Length:811 Species:Homo sapiens


Alignment Length:500 Identity:121/500 - (24%)
Similarity:170/500 - (34%) Gaps:190/500 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    62 LLWLLCCCSQLGQLRAE--CPAVCECKWKSGKESVLCLNANL------THIPQPLDAGT------ 112
            ||.::|.|..|..| ||  ||..|:|:   ..:.:||.|..|      :.:|.|.|..|      
Human     9 LLLVVCGCLALPPL-AEPVCPERCDCQ---HPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGN 69

  Fly   113 --------------QL--LDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRL----------- 150
                          ||  |||..|:|:.:...:|  .:|..|:::||....|:.           
Human    70 FITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTF--EKLSRLEELYLGNNLLQALAPGTLAPLRK 132

  Fly   151 -------------IERHAFRKLINLVELDLSQNLLSAIPSL------------------------ 178
                         :.|.:|..|.:||:|.|..|.|.|:|..                        
Human   133 LRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKN 197

  Fly   179 ALYHVSELRELRLSGN---PILR-----------------------VPDDAFGHVPQLVKLELSD 217
            |...:.:||.|.||.|   |.||                       :....|.|:|:|..|.|..
Human   198 AFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLRG 262

  Fly   218 CRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNT-------------- 268
            .:|:|:|..||.||| :|..|:|:|||||::.:..:..|.||..|:|:.|.              
Human   263 NQLTHLAPEAFWGLE-ALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGR 326

  Fly   269 ----------------------------------WNCSCSLRPLRAWM---LQQNIPSGIPPTCE 296
                                              |.|.|.||.|:.||   ..|.....:...|.
Human   327 LRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWMGDWHSQGRLLTVFVQCR 391

  Fly   297 SPPRLSGRAWDKLD---VDDFACVPQIVATDTTAH-------GVEGRNITMSCYV--EGVPQP-- 347
            .||.|.|:..|.||   :.:.:|.....:...||.       ...|..:|....:  |..|||  
Human   392 HPPALRGKYLDYLDDQQLQNGSCADPSPSASLTADRRRQPLPTAAGEEMTPPAGLAEELPPQPQL 456

  Fly   348 --------AVKW------LLKNRLIANLSAGGDGDSDSEPRTAAA 378
                    .|.|      |:.||....||..|.|.....|..|||
Human   457 QQQGRFLAGVAWDGAARELVGNRSALRLSRRGPGLQQPSPSVAAA 501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 62/252 (25%)
leucine-rich repeat 112..137 CDD:275380 10/46 (22%)
LRR_8 137..196 CDD:290566 22/109 (20%)
leucine-rich repeat 138..161 CDD:275380 7/46 (15%)
leucine-rich repeat 162..185 CDD:275380 9/46 (20%)
LRR_8 184..245 CDD:290566 28/86 (33%)
leucine-rich repeat 186..209 CDD:275380 11/48 (23%)
leucine-rich repeat 210..234 CDD:275380 11/23 (48%)
leucine-rich repeat 235..258 CDD:275380 9/22 (41%)
LRRCT 267..316 CDD:214507 18/102 (18%)
IG_like 328..428 CDD:214653 18/75 (24%)
Ig 335..425 CDD:143165 17/61 (28%)
TRILNP_055632.2 LRR_RI <2..194 CDD:238064 44/190 (23%)
leucine-rich repeat 37..61 CDD:275380 6/23 (26%)
LRR 1 61..81 1/19 (5%)
leucine-rich repeat 62..84 CDD:275380 1/21 (5%)
LRR_8 84..143 CDD:290566 13/60 (22%)
LRR 2 84..105 8/22 (36%)
leucine-rich repeat 85..108 CDD:275380 8/24 (33%)
LRR 3 108..129 4/20 (20%)
leucine-rich repeat 109..132 CDD:275380 4/22 (18%)
LRR 4 132..153 2/20 (10%)
leucine-rich repeat 133..156 CDD:275380 3/22 (14%)
LRR_8 156..215 CDD:290566 15/58 (26%)
LRR 5 156..177 8/20 (40%)
leucine-rich repeat 157..180 CDD:275380 8/22 (36%)
LRR 6 180..201 1/20 (5%)
leucine-rich repeat 181..204 CDD:275380 1/22 (5%)
LRR 7 204..223 9/18 (50%)
leucine-rich repeat 205..254 CDD:275380 11/48 (23%)
LRR 8 230..251 1/20 (5%)
LRR_8 239..289 CDD:290566 19/50 (38%)
LRR_RI <249..>364 CDD:238064 29/115 (25%)
LRR 9 254..275 8/20 (40%)
leucine-rich repeat 255..278 CDD:275380 11/23 (48%)
LRR 10 278..299 8/20 (40%)
LRR_8 279..337 CDD:290566 14/57 (25%)
leucine-rich repeat 279..302 CDD:275380 9/22 (41%)
LRR 11 302..323 5/20 (25%)
leucine-rich repeat 303..326 CDD:275380 4/22 (18%)
LRR 12 326..347 0/20 (0%)
leucine-rich repeat 327..346 CDD:275380 0/18 (0%)
leucine-rich repeat 351..363 CDD:275378 1/11 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..549 7/17 (41%)
fn3 589..667 CDD:278470
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141310
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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