DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and LRRC4B

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001073926.1	Gene:	LRRC4B / 94030	HGNCID:	25042	Length:	713	Species:	Homo sapiens

Alignment Length:	750	Identity:	186/750 - (24%)
Similarity:	266/750 - (35%)	Gaps:	209/750 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PPLRPRLPLHLHLLLWL-----------LCCCSQLG---QLRAECPAVCECKWKSGKESVLCLNA 99
            ||.|...|....|.|||           :...|..|   .....||..|.|..::.:  |:|...
Human    13 PPGRMSWPHGALLFLWLFSPPLGAGGGGVAVTSAAGGGSPPATSCPVACSCSNQASR--VICTRR 75

  Fly   100 NLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVE 164
            :|..:|..:...|:.|:|..|.||:|..|:|  ..|.:|:.:.|::..:|.||..||..|.:|..
Human    76 DLAEVPASIPVNTRYLNLQENGIQVIRTDTF--KHLRHLEILQLSKNLVRKIEVGAFNGLPSLNT 138

  Fly   165 LDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDC-RLSHIAVRAF 228
            |:|..|.|:.:|:.|..::|:||||.|..|||..:|..||..||.|.:|:|.:. ||.:|:..||
Human   139 LELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAF 203

  Fly   229 AGLES---------------------SLEWLKLDGNRLSEVRSGTITSLAS-------------- 258
            .||.:                     .||.|:|.||||..:|.|:...|.|
Human   204 EGLVNLRYLNLGMCNLKDIPNLTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATI 268

  Fly   259 -------------------------------LHGLE---LARNTWNCSCSLRPLRAWMLQQNIPS 289
                                           ||.||   |..|.|:|:|.:..| :|.|::.:||
Human   269 ERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWL-SWWLKETVPS 332

  Fly   290 GIP--PTCESPPRLSGRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKW 351
            ...  ..|.:|..|.||...:||...|.| .|.||...|..:..||....:.|.. |....:|.|
Human   333 NTTCCARCHAPAGLKGRYIGELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRT-GTSMTSVNW 396

  Fly   352 LLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNAS-NLTILTADMQDAGIYTCAAEN 415
            |                   .|.....|.|.....:::|.:.: |.|.:|  :||.|.|||...|
Human   397 L-------------------TPNGTLMTHGSYRVRISVLHDGTLNFTNVT--VQDTGQYTCMVTN 440

  Fly   416 KAGKVEASVTLAVSRRPPEA----------PWGVRIILLGAVAALLLVGGSS----FAAICLCSL 466
            .||...||.||.||...|.|          |.|     .|.|.     |||.    |..:.:.:|
Human   441 SAGNTTASATLNVSAVDPVAAGGTGSGGGGPGG-----SGGVG-----GGSGGYTYFTTVTVETL 495

  Fly   467 QRR---RKLR---------------LW---------------NSVPPVRRSESYEK------IEM 492
            :.:   ..|:               :|               .:.|..|.|...||      .::
Human   496 ETQPGEEALQPRGTEKEPPGPTTDGVWGGGRPGDAAGPASSSTTAPAPRSSRPTEKAFTVPITDV 560

  Fly   493 TARTRPDL-----------GGGASCGGGSATGAGLFHDAEEQGYLRAAHTP------LNDNDAGQ 540
            |.....||           |...:....:|.....|:...:|..|...|.|      :|..|...
Human   561 TENALKDLDDVMKTTKIIIGCFVAITFMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELP 625

  Fly   541 AAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGH 605
            ||:.|:.:|.:|....|.....|.......|...|:||.....|.:.|...|.
Human   626 AASAVSVAAAAAVASGGGVGGDSHLALPALERDHLNHHHYVAAAFKAHYSSNP------------ 678

  Fly   606 VVSASGANNSAPLEETDLHIPRLIDIGGTDSASSS 640
              |..|.....|.....:|.|.|...|..::...:
Human   679 --SGGGCGGKGPPGLNSIHEPLLFKSGSKENVQET 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	66/226 (29%)
		leucine-rich repeat	112..137	CDD:275380	10/24 (42%)
		LRR_8	137..196	CDD:290566	22/58 (38%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	30/82 (37%)
		leucine-rich repeat	186..209	CDD:275380	12/22 (55%)
		leucine-rich repeat	210..234	CDD:275380	10/45 (22%)
		leucine-rich repeat	235..258	CDD:275380	11/22 (50%)
		LRRCT	267..316	CDD:214507	17/50 (34%)
		IG_like	328..428	CDD:214653	27/100 (27%)
		Ig	335..425	CDD:143165	23/90 (26%)
LRRC4B	NP_001073926.1	LRRNT	57..90	CDD:214470	9/34 (26%)
		LRR	<76..297	CDD:227223	63/222 (28%)
		LRR 1	87..108		9/22 (41%)
		leucine-rich repeat	88..111	CDD:275380	10/24 (42%)
		LRR 2	111..132		7/20 (35%)
		leucine-rich repeat	112..135	CDD:275380	8/22 (36%)
		LRR 3	135..156		7/20 (35%)
		leucine-rich repeat	136..159	CDD:275380	7/22 (32%)
		LRR 4	159..180		11/20 (55%)
		leucine-rich repeat	160..183	CDD:275380	12/22 (55%)
		LRR 5	183..205		8/21 (38%)
		leucine-rich repeat	184..208	CDD:275380	10/23 (43%)
		LRR 6	208..229		0/20 (0%)
		leucine-rich repeat	209..230	CDD:275380	0/20 (0%)
		LRR 7	230..251		10/20 (50%)
		leucine-rich repeat	231..254	CDD:275380	11/22 (50%)
		LRR 8	254..275		1/20 (5%)
		leucine-rich repeat	255..278	CDD:275380	0/22 (0%)
		LRR 9	278..299		0/20 (0%)
		leucine-rich repeat	279..300	CDD:275380	0/20 (0%)
		LRRCT	311..361	CDD:214507	17/50 (34%)
		I-set	364..453	CDD:254352	31/110 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..551		5/53 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..713		4/17 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	1	0.900	-	-		OOG6_104601
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5308
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840