DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek3 and LGR5

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_003658.1 Gene:LGR5 / 8549 HGNCID:4504 Length:907 Species:Homo sapiens


Alignment Length:212 Identity:73/212 - (34%)
Similarity:103/212 - (48%) Gaps:13/212 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 LHLHLLLWLLCCCS--QLGQLRAECPAVCECKWKSGKE--SVLCLNANLTHIPQPLDAGTQLLDL 117
            |.|.:||.|....|  :.|.|...||..|.|: ..|:.  .|.|.:..|:.:|..|...|..|||
Human    10 LSLPVLLQLATGGSSPRSGVLLRGCPTHCHCE-PDGRMLLRVDCSDLGLSELPSNLSVFTSYLDL 73

  Fly   118 SGNEI-QLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALY 181
            |.|.| ||:|:   ....|..|:::.||...|..|.:.||..|.:|..|.|..|.|..:|:.||.
Human    74 SMNNISQLLPN---PLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQ 135

  Fly   182 HVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLS 246
            ::..|:.|||..|.|..||...|..:..|..|.|.|..|:.|.|:||..| |:|:.:.|..|::.
Human   136 NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSL-SALQAMTLALNKIH 199

  Fly   247 EVRS---GTITSLASLH 260
            .:..   |.::||..||
Human   200 HIPDYAFGNLSSLVVLH 216

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 55/155 (35%)
leucine-rich repeat 112..137 CDD:275380 11/25 (44%)
LRR_8 137..196 CDD:290566 21/58 (36%)
leucine-rich repeat 138..161 CDD:275380 8/22 (36%)
leucine-rich repeat 162..185 CDD:275380 8/22 (36%)
LRR_8 184..245 CDD:290566 23/60 (38%)
leucine-rich repeat 186..209 CDD:275380 9/22 (41%)
leucine-rich repeat 210..234 CDD:275380 10/23 (43%)
leucine-rich repeat 235..258 CDD:275380 6/25 (24%)
LRRCT 267..316 CDD:214507
IG_like 328..428 CDD:214653
Ig 335..425 CDD:143165
LGR5NP_003658.1 LRRNT 33..70 CDD:214470 11/37 (30%)
leucine-rich repeat 68..91 CDD:275380 11/25 (44%)
PLN00113 71..>426 CDD:215061 54/150 (36%)
leucine-rich repeat 92..115 CDD:275380 8/22 (36%)
leucine-rich repeat 116..139 CDD:275380 8/22 (36%)
leucine-rich repeat 140..163 CDD:275380 9/22 (41%)
leucine-rich repeat 164..187 CDD:275380 10/23 (43%)
leucine-rich repeat 188..211 CDD:275380 4/22 (18%)
leucine-rich repeat 212..235 CDD:275380 3/5 (60%)
leucine-rich repeat 236..258 CDD:275380
leucine-rich repeat 259..282 CDD:275380
leucine-rich repeat 283..304 CDD:275380
leucine-rich repeat 307..353 CDD:275378
leucine-rich repeat 354..375 CDD:275378
leucine-rich repeat 376..389 CDD:275378
leucine-rich repeat 400..423 CDD:275378
leucine-rich repeat 445..459 CDD:275378
7tmA_LGR5 558..831 CDD:320485
TM helix 1 559..585 CDD:320485
TM helix 2 592..617 CDD:320485
TM helix 3 637..667 CDD:320485
TM helix 4 679..701 CDD:320485
TM helix 5 721..750 CDD:320485
TM helix 6 759..789 CDD:320485
TM helix 7 799..824 CDD:320485
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165141337
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

Return to query results.
Submit another query.