Protein Alignment kek3 and LINGO1

DIOPT Version :9

• Sequence 1: NP_001162986.1
• Gene: kek3 / 34912
• FlyBaseID: FBgn0028370
• Length: 1021
• Species: Drosophila melanogaster
• Sequence 2: NP_116197.4
• Gene: LINGO1 / 84894
• HGNCID: 21205
• Length: 620
• Species: Homo sapiens
• Alignment Length: 562
• Identity: 126/562 - (22%)
• Similarity: 181/562 - (32%)
• Gaps: 198/562 - (35%)

  Fly    29 RRTLATKVRRKGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKES 93
            :|.||..||.. |.|......|:       |.|:|..:...|..|     ||..|||  .:...:
Human     5 KRMLAGGVRSM-PSPLLACWQPI-------LLLVLGSVLSGSATG-----CPPRCEC--SAQDRA 54

  Fly    94 VLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFAT----------------------AQLL 136
            |||.......:|:.:...|:||||..|.|:.:..|.||:                      ..|.
Human    55 VLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLF 119

  Fly   137 NLQKVYLARCHLRLIERHAFRKLINLVELDLSQNL------------------------------ 171
            ||:.:.|....|:||....|..|.||.:||:|:|.
Human   120 NLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISH 184

  Fly   172 ----------------------------------------------------------------- 171
                                                                             
Human   185 RAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHW 249

  Fly   172 -------------------------LSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLV 211
                                     |:|:|.||:.|:..||.|.||.|||..:.......:.:|.
Human   250 PYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQ 314

  Fly   212 KLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLR 276
            :::|...:|:.:...||.|| :.|..|.:.||:|:.:......|:.:|..|.|..|...|.|.|.
Human   315 EIQLVGGQLAVVEPYAFRGL-NYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLL 378

  Fly   277 PL--RAWMLQQNIPSGIPPTCESPPRLSGRAW----DKLDVDDFACVPQIVATDTTAHGV---EG 332
            .:  |.|.|..|...   |||.:|..:.|:.:    |.|..:.|.| .:....|..|..|   ||
Human   379 WVFRRRWRLNFNRQQ---PTCATPEFVQGKEFKDFPDVLLPNYFTC-RRARIRDRKAQQVFVDEG 439

  Fly   333 RNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPR---TAAATQGRKTYVVNMLRNAS 394
            ..:...|..:|.|.||:.||                   .||   .:|.:.||.|...:     .
Human   440 HTVQFVCRADGDPPPAILWL-------------------SPRKHLVSAKSNGRLTVFPD-----G 480

  Fly   395 NLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAP 436
            .|.:..|.:||.|.|.|.|.|..|.......|.|....|:.|
Human   481 TLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWP 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	55/298 (18%)
		leucine-rich repeat	112..137	CDD:275380	11/46 (24%)
		LRR_8	137..196	CDD:290566	26/178 (15%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	11/142 (8%)
		LRR_8	184..245	CDD:290566	19/60 (32%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	7/23 (30%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	16/54 (30%)
		IG_like	328..428	CDD:214653	27/105 (26%)
		Ig	335..425	CDD:143165	23/92 (25%)
LINGO1	NP_116197.4	LRRNT	41..75	CDD:214470	11/40 (28%)
		LRR	<66..371	CDD:227223	57/305 (19%)
		LRR 1	72..93		9/20 (45%)
		leucine-rich repeat	73..96	CDD:275380	10/22 (45%)
		LRR 2	96..117		0/20 (0%)
		leucine-rich repeat	97..120	CDD:275380	1/22 (5%)
		LRR_8	120..179	CDD:338972	14/58 (24%)
		LRR 3	120..141		7/20 (35%)
		leucine-rich repeat	121..144	CDD:275380	7/22 (32%)
		LRR 4	144..165		6/20 (30%)
		leucine-rich repeat	145..192	CDD:275380	5/46 (11%)
		LRR 5	168..189		0/20 (0%)
		LRR 6	192..213		0/20 (0%)
		leucine-rich repeat	193..216	CDD:275380	0/22 (0%)
		LRR 7	216..237		0/20 (0%)
		leucine-rich repeat	217..264	CDD:275380	0/46 (0%)
		LRR 8	264..285		5/20 (25%)
		leucine-rich repeat	265..288	CDD:275380	6/22 (27%)
		LRR 9	288..309		8/20 (40%)
		leucine-rich repeat	289..312	CDD:275380	8/22 (36%)
		LRR 10	312..333		5/20 (25%)
		leucine-rich repeat	313..336	CDD:275380	7/23 (30%)
		LRR 11	336..357		5/20 (25%)
		leucine-rich repeat	337..357	CDD:275380	5/19 (26%)
		PCC	341..>421	CDD:188093	23/82 (28%)
		Ig	439..514	CDD:386229	25/98 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910