DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and HSL1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_174166.1	Gene:	HSL1 / 839742	AraportID:	AT1G28440	Length:	996	Species:	Arabidopsis thaliana

Alignment Length:	638	Identity:	135/638 - (21%)
Similarity:	215/638 - (33%)	Gaps:	198/638 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SGQDIASDNSAQRRTLATKVRRKGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAECPA 81
            ||...|.|.|:......:.....||      .|.:..||....||.|:.....|.|....|.|.:
plant    51 SGVSCAGDFSSVTSVDLSSANLAGP------FPSVICRLSNLAHLSLYNNSINSTLPLNIAACKS 109

  Fly    82 VCECKWKSGKESVLCLNANLT--HIPQPL-DAGTQL-LDLSGNEIQ------------------- 123
            :          ..|.|:.||.  .:||.| |..|.: |||:||...
plant   110 L----------QTLDLSQNLLTGELPQTLADIPTLVHLDLTGNNFSGDIPASFGKFENLEVLSLV 164

  Fly   124 ------LIPD--DSFATAQLL--------------------NLQKVYLARCHLRLIERHAFRKLI 160
                  .||.  .:.:|.::|                    ||:.::|..|||......:..:|.
plant   165 YNLLDGTIPPFLGNISTLKMLNLSYNPFSPSRIPPEFGNLTNLEVMWLTECHLVGQIPDSLGQLS 229

  Fly   161 NLVELDLSQN-LLSAIP----------SLALYH----------VSELRELRL---SGNPIL-RVP 200
            .||:|||:.| |:..||          .:.||:          :..|:.|||   |.|.:. ::|
plant   230 KLVDLDLALNDLVGHIPPSLGGLTNVVQIELYNNSLTGEIPPELGNLKSLRLLDASMNQLTGKIP 294

  Fly   201 DDAFGHVPQLVKLELSDCRL-----SHIA-------VRAFA-----------GLESSLEWLKLDG 242
            |: ...|| |..|.|.:..|     :.||       :|.|.           ||.|.|.||.:..
plant   295 DE-LCRVP-LESLNLYENNLEGELPASIALSPNLYEIRIFGNRLTGGLPKDLGLNSPLRWLDVSE 357

  Fly   243 NRLSEVRSGTITSLASLHGLELARNTWN-------CSCSLRPLRAWMLQQNIPSGIPPTCESPPR 300
            |..|......:.:...|..|.:..|:::       ..|  |.|....|..|..||..||
plant   358 NEFSGDLPADLCAKGELEELLIIHNSFSGVIPESLADC--RSLTRIRLAYNRFSGSVPT------ 414

  Fly   301 LSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRL-------- 357
                        .|..:|.:...:...:...|.   :|..:.|....::..|..|..
plant   415 ------------GFWGLPHVNLLELVNNSFSGE---ISKSIGGASNLSLLILSNNEFTGSLPEEI 464

  Fly   358 -----IANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKA 417
                 :..|||.|:..|.|.|.:..:.....|..::..:.:..||        :||.:....|:.
plant   465 GSLDNLNQLSASGNKFSGSLPDSLMSLGELGTLDLHGNQFSGELT--------SGIKSWKKLNEL 521

  Fly   418 GKVEASVTLAVSRRPPEAPWGVRIILLGAVAAL--LLVGGSSFAAICLCSLQ--RRRKL-----R 473
            ...:...|   .:.|.|         :|:::.|  |.:.|:.|:.....|||  :..:|     |
plant   522 NLADNEFT---GKIPDE---------IGSLSVLNYLDLSGNMFSGKIPVSLQSLKLNQLNLSYNR 574

  Fly   474 LWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYL 526
            |...:||....:.|:        ...:|....||..... .|..::|:::||:
plant   575 LSGDLPPSLAKDMYK--------NSFIGNPGLCGDIKGL-CGSENEAKKRGYV 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	56/252 (22%)
		leucine-rich repeat	112..137	CDD:275380	10/72 (14%)
		LRR_8	137..196	CDD:290566	24/82 (29%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	11/43 (26%)
		LRR_8	184..245	CDD:290566	25/87 (29%)
		leucine-rich repeat	186..209	CDD:275380	9/26 (35%)
		leucine-rich repeat	210..234	CDD:275380	10/46 (22%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	11/55 (20%)
		IG_like	328..428	CDD:214653	19/112 (17%)
		Ig	335..425	CDD:143165	17/102 (17%)
HSL1	NP_174166.1	PLN00113	22..960	CDD:215061	135/638 (21%)
		leucine-rich repeat	62..85	CDD:275380	5/28 (18%)
		leucine-rich repeat	86..109	CDD:275380	7/22 (32%)
		leucine-rich repeat	110..133	CDD:275380	8/32 (25%)
		leucine-rich repeat	134..157	CDD:275380	5/22 (23%)
		leucine-rich repeat	158..181	CDD:275380	2/22 (9%)
		leucine-rich repeat	182..206	CDD:275380	1/23 (4%)
		leucine-rich repeat	207..230	CDD:275380	6/22 (27%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		leucine-rich repeat	255..278	CDD:275380	3/22 (14%)
		leucine-rich repeat	279..300	CDD:275380	7/21 (33%)
		leucine-rich repeat	302..325	CDD:275380	6/22 (27%)
		leucine-rich repeat	326..344	CDD:275380	2/17 (12%)
		leucine-rich repeat	350..370	CDD:275380	5/19 (26%)
		leucine-rich repeat	374..397	CDD:275380	4/24 (17%)
		leucine-rich repeat	398..421	CDD:275380	8/40 (20%)
		leucine-rich repeat	422..445	CDD:275380	3/25 (12%)
		leucine-rich repeat	446..469	CDD:275380	2/22 (9%)
		leucine-rich repeat	470..493	CDD:275380	7/22 (32%)
		leucine-rich repeat	494..517	CDD:275380	5/30 (17%)
		leucine-rich repeat	518..541	CDD:275380	5/34 (15%)
		leucine-rich repeat	542..564	CDD:275380	7/21 (33%)
		leucine-rich repeat	565..584	CDD:275380	5/18 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910