DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lrfn1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001135393.1	Gene:	Lrfn1 / 80749	MGIID:	2136810	Length:	766	Species:	Mus musculus

Alignment Length:	441	Identity:	114/441 - (25%)
Similarity:	169/441 - (38%)	Gaps:	88/441 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHI 104
            ||.......||     |..|..|| ||...:..||   .||..|.|:..:...::||....|..:
Mouse     4 GPFSSGLFSPP-----PAALPFLL-LLWAGASRGQ---PCPGRCICQNVAPTLTMLCAKTGLLFV 59

  Fly   105 PQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQ 169
            |..:|.....|.|:.|.|..:....|  |.:.:|..:.|:|..:..:...||..|..|..|.|..
Mouse    60 PPAIDRRVVELRLTDNFIAAVRRRDF--ANMTSLVHLTLSRNTIGQVAAGAFADLRALRALHLDS 122

  Fly   170 NLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVK-LELSDCRLSHIAVRAFAGLES 233
            |.|:.:....|..:..||.|.|..|.|.:|...||......|: |:||...|..:...| .|...
Mouse   123 NRLAEVRGDQLRGLGNLRHLILGNNQIRKVESAAFDAFLSTVEDLDLSYNNLEALPWEA-VGQMV 186

  Fly   234 SLEWLKLDGNRLSEVRSGTITSLASLHGLELAR-------------------------------- 266
            :|..|.||.|.:..:..||...|..|..|::..
Mouse   187 NLNTLTLDHNLIDHIAEGTFVQLHKLVRLDMTSNRLHKLPPDGLFLRSQGGGPKPPTPLTVSFGG 251

  Fly   267 NTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHG-- 329
            |..:|:|.|..||....:.::     .||.:|..|:.|.:..:..::|.|.|.::........
Mouse   252 NPLHCNCELLWLRRLTREDDL-----ETCATPEHLTDRYFWSIPEEEFLCEPPLITRQAGGRALV 311

  Fly   330 VEGRNITMSCYVEGVPQPAVKWLLKN-RLIANLS---AGGDGDSDSEPRTAAATQGRKTYVVNML 390
            |||:.:::.|...|.|:|.|.|:..: ||:.|.|   ..|||..|
Mouse   312 VEGQAVSLRCRAVGDPEPVVHWVAPDGRLLGNSSRTRVRGDGTLD-------------------- 356

  Fly   391 RNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAV-----SRRPPEAP 436
                 :||.|  ::|:|.:||.|.|.||:..|.|.:.|     ...||.||
Mouse   357 -----VTITT--LRDSGTFTCIASNAAGEATAPVEVCVVPLPLMAPPPAAP 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	44/189 (23%)
		leucine-rich repeat	112..137	CDD:275380	6/24 (25%)
		LRR_8	137..196	CDD:290566	17/58 (29%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	21/61 (34%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	7/24 (29%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	12/48 (25%)
		IG_like	328..428	CDD:214653	30/105 (29%)
		Ig	335..425	CDD:143165	26/93 (28%)
Lrfn1	NP_001135393.1	LRR 1	66..87		5/22 (23%)
		leucine-rich repeat	67..90	CDD:275380	6/24 (25%)
		PPP1R42	70..226	CDD:411060	44/158 (28%)
		LRR 2	90..111		5/20 (25%)
		leucine-rich repeat	91..114	CDD:275380	6/22 (27%)
		LRR 3	114..135		6/20 (30%)
		leucine-rich repeat	115..138	CDD:275380	6/22 (27%)
		LRR 4	138..159		9/20 (45%)
		leucine-rich repeat	139..163	CDD:275380	9/23 (39%)
		LRR 5	163..184		6/21 (29%)
		leucine-rich repeat	164..187	CDD:275380	7/23 (30%)
		LRR 6	187..208		7/20 (35%)
		leucine-rich repeat	188..211	CDD:275380	8/22 (36%)
		LRR 7	211..232		2/20 (10%)
		leucine-rich repeat	212..230	CDD:275380	2/17 (12%)
		LRRCT	252..>284	CDD:214507	10/36 (28%)
		Ig	299..387	CDD:416386	30/114 (26%)
		Ig strand A	299..302	CDD:409353	0/2 (0%)
		Ig strand A'	306..310	CDD:409353	0/3 (0%)
		Ig strand B	316..324	CDD:409353	1/7 (14%)
		Ig strand C	330..335	CDD:409353	2/4 (50%)
		Ig strand C'	338..340	CDD:409353	0/1 (0%)
		Ig strand D	346..350	CDD:409353	0/3 (0%)
		Ig strand E	353..357	CDD:409353	2/28 (7%)
		Ig strand F	367..374	CDD:409353	3/6 (50%)
		Ig strand G	377..387	CDD:409353	3/9 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..424		3/4 (75%)
		FN3	426..500	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..601
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..742
		PDZ-binding	763..766
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43981
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910