DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and mxra5b

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_017213354.1	Gene:	mxra5b / 795448	ZFINID:	ZDB-GENE-081104-119	Length:	2548	Species:	Danio rerio

Alignment Length:	1250	Identity:	231/1250 - (18%)
Similarity:	379/1250 - (30%)	Gaps:	491/1250 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPD 127
            |:||......|.....||..|.|   |....|.|....|..:|..:....|.::...|.|..|.|
Zfish     6 LFLLVLLVSFGLCSGVCPRQCAC---SAPAEVHCTFRALLAVPAGISKQVQRINFGFNTISQITD 67

  Fly   128 DSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLS 192
            .||:     .|:|:.|...|                     .|.:..||..|...:..|:.|::|
Zfish    68 ASFS-----GLRKLELLMMH---------------------GNNVQKIPDGAFQDLVSLQVLKMS 106

  Fly   193 GNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGT----- 252
            .|.:..:.|..|..:..:::|.|....:|.|..:||.|| :||..|.|:.|||.::...|
Zfish   107 YNKLTVITDRTFSGLTGIIRLHLDHNHISSIHPQAFLGL-TSLRLLHLEANRLQQLHPHTFSTFS 170

  Fly   253 ------ITSLASLH---------------------GLELARNTWNCSCSLRPLRAWMLQ------ 284
                  :::|..||                     .|.|..|.|:|.|.:|.|:.|..:
Zfish   171 VLRRFPVSTLKHLHISDNLLQTLSRSVLENTPQLETLLLTGNPWSCDCRMRWLQDWSARHPGVMK 235

  Fly   285 ----QNIPSG-IPPTCESPPRLSGRAWDKLDVDDFACV-PQIVA-------TDTT---------- 326
                :...|| :.|.|.||..|  :|.|.||:....|. |.|::       .||:
Zfish   236 CKKDRTFTSGQLCPLCASPKHL--KAADMLDLKQLVCSGPSIISPGRNISEEDTSELLPIDRIKP 298

  Fly   327 -----------AHGVE--------------------------GRNITM----SC----------- 339
                       .||.:                          ..|:|:    .|
Zfish   299 AFGNVSFTLSDEHGTKVDLICQILQPQDSTTISWNHTKSLQIAANVTLVLDVECPVSRDDYESFW 363

  Fly   340 ----YVEGVP-----------QPAV--------------------------KWLLKN-------- 355
                |....|           :||:                          .||:::
Zfish   364 RLLAYYSEAPVHLRREIMLRREPALSYRYRQDAEKDGFFYTSLKANVLAHPSWLMQSLISIKLNR 428

  Fly   356 --------RLI--ANLSAGGDG---------DSDSEPRTAAAT------------QGRKTYVVN- 388
                    |||  ..|:|..|.         ::|::.:|:.|:            |.....|:.
Zfish   429 PYSTSKSVRLILSTQLTANADEENVRSWVMIENDNKTQTSFASVVGGVAEMHCRVQSSGNAVIYW 493

  Fly   389 MLRNAS-------------------NLTILTADMQDAGIYTCAAE---------NKAGKVEASVT 425
            ||.|.|                   .|.|.|.:.:|:|:|.|.||         .:...:|:|..
Zfish   494 MLPNGSKVKSAFSSVDGRVSISSSGKLNIKTIEHRDSGVYYCIAEVDGDVDVLPFRLSVIESSNP 558

  Fly   426 L--------------------AVSRRPPEA------PWGVRIILLGAVA----ALLLVGGSSFAA 460
            |                    .:::..|:|      |.|   .:|.|.|    |||...|:.:..
Zfish   559 LPNQEVGNSLSRFIGQSAFLTCLTKASPDAEINWVLPDG---NVLNAKANTSRALLFPNGTLYIP 620

  Fly   461 IC--------LCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLF 517
            :|        .|.......:.::::...|.|.:..:.:......||.     |..|.|.......
Zfish   621 VCQLNDNGYYKCVAMNNHGVDVFSTKLTVIRRKLIQPLRQYPIIRPQ-----SAAGVSTKVKAFL 680

  Fly   518 HDAEE-QGYLRAAH-TPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQ 580
            .|.|| .|.:.... ||....         .|:|    ||.|:..|
Zfish   681 EDMEEASGDISETRLTPTRRR---------RPNA----RRFGNIRH------------------- 713

  Fly   581 QQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGG--TDSASSSISS 643
            ::|.......|||:             ..:..|...|.:..||    |..|..  ::|..|..|.
Zfish   714 RRPFRNRAGLPNQR-------------PVNTKNKIDPQKWADL----LSKIRAKTSESNKSLQSG 761

  Fly   644 QVDAAARLAGYAG---HTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPA----- 700
            .:|.....:|.:|   .|:.|....|.:|.......:....||.|:|..:....|.:||.
Zfish   762 LIDNTESSSGDSGPQEKTFNTDVYHTPQIKERDDDNIYRTTPSQLHTTRSNQVLYISHPTSAPHY 826

  Fly   701 ------DEMATSVFCSEGQ-------------ESDL-----------FDSNYPDLLDIAKYAVAQ 735
                  |..|::|.....|             |::|           |||..   :|...:|.|.
Zfish   827 VTTHVQDRHASTVNAENNQIYSESVISPELETENELNLPGVKSQIGGFDSGG---IDRNVFATAS 888

  Fly   736 AQQEGRGQGYAQATTTPN------------GG---------LCTLPR----KLKTSGKYFRNSSD 775
            :         .:.::.||            ||         :..||.    ...|:.:....:.|
Zfish   889 S---------VRLSSAPNSTQSRGRDRWRFGGRRRIKFRRPISNLPTSRVWSTSTTARVTLKTDD 944

  Fly   776 SQSPLLADNSSKYG-------------SSTLGDGSFLNEAMGLGRRYSAESSYANYSSTATYTGG 827
            ..:.:.....||..             |:||..|..:|         ..:||:. |.:
Zfish   945 QDASIYPTTPSKVPSVSQTIPVTLHVYSTTLSRGIPIN---------PTQSSHI-YPT------- 992

  Fly   828 GQRANSFLNLVQSGAHQGKLLPSHLGQ-KPSLPSSPVQHQRSLSSAATPLL-----DFSALASRA 886
              :.|...|.|:...:. |:..|:..| :..:|:|  :...::|:.|:.:|     ||::|....
Zfish   993 --KHNELTNEVEENINH-KVKESNFQQTQQVMPNS--RFHPTISTNASAVLRLANEDFNSLEKEE 1052

  Fly   887 AGAANTSVAAYDYHAAQLERFLEEYRNLQDQLCKMKETCDTIRKKETPLRVAIGQSAAQLA---- 947
            ...:..|       |.:::.::...|         |.....:..|..||.....:..::|:
Zfish  1053 QDGSFAS-------AEEMDEYIVPTR---------KHPTSRLGAKTVPLTTPRLEFTSRLSADIP 1101

  Fly   948 --DPVMYSAASHSPK 960
              ||...|...|:.:
Zfish  1102 KMDPTEISVTVHTDR 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	42/188 (22%)
		leucine-rich repeat	112..137	CDD:275380	7/24 (29%)
		LRR_8	137..196	CDD:290566	12/58 (21%)
		leucine-rich repeat	138..161	CDD:275380	4/22 (18%)
		leucine-rich repeat	162..185	CDD:275380	4/22 (18%)
		LRR_8	184..245	CDD:290566	19/60 (32%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	8/33 (24%)
		LRRCT	267..316	CDD:214507	18/59 (31%)
		IG_like	328..428	CDD:214653	38/269 (14%)
		Ig	335..425	CDD:143165	34/213 (16%)
mxra5b	XP_017213354.1	leucine-rich repeat	33..51	CDD:275380	4/17 (24%)
		LRR_8	50..110	CDD:290566	19/85 (22%)
		leucine-rich repeat	52..75	CDD:275380	8/27 (30%)
		leucine-rich repeat	76..99	CDD:275380	6/43 (14%)
		LRR_8	99..158	CDD:290566	19/59 (32%)
		leucine-rich repeat	100..123	CDD:275380	6/22 (27%)
		leucine-rich repeat	124..147	CDD:275380	8/23 (35%)
		LRR_8	146..213	CDD:290566	13/66 (20%)
		leucine-rich repeat	148..179	CDD:275380	7/30 (23%)
		leucine-rich repeat	180..203	CDD:275380	3/22 (14%)
		LRRCT	212..>258	CDD:214507	14/47 (30%)
		IG	472..552	CDD:214652	15/79 (19%)
		Ig	477..538	CDD:143165	13/60 (22%)
		IG	567..649	CDD:214652	13/84 (15%)
		Ig	573..639	CDD:299845	13/68 (19%)
		IG_like	1583..1666	CDD:214653
		Ig	1592..1656	CDD:299845
		I-set	1671..1763	CDD:254352
		Ig	1686..1763	CDD:299845
		IG	1776..1860	CDD:214652
		Ig	1783..1860	CDD:299845
		I-set	1875..1959	CDD:254352
		IGc2	1882..1949	CDD:197706
		IG	1979..2062	CDD:214652
		Ig	1979..2053	CDD:299845
		I-set	2075..2156	CDD:254352
		Ig	2082..2146	CDD:299845
		IG	2175..2255	CDD:214652
		Ig	2180..2255	CDD:299845
		IG_like	2271..2351	CDD:214653
		IGc2	2276..2343	CDD:197706
		IG	2372..2438	CDD:214652
		Ig	2377..2438	CDD:143165
		IG	2462..2547	CDD:214652
		Ig	2471..2544	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910