DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and LRFN3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_078785.1	Gene:	LRFN3 / 79414	HGNCID:	28370	Length:	628	Species:	Homo sapiens

Alignment Length:	669	Identity:	159/669 - (23%)
Similarity:	227/669 - (33%)	Gaps:	189/669 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLD---------- 109
            |||.|.||..............:.||..|.|:.:|...||||..|.|..:|..||
Human     4 LPLLLCLLPLAPASSPPQSATPSPCPRRCRCQTQSLPLSVLCPGAGLLFVPPSLDRRAAELRLAD 68

  Fly   110 --------------AGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLI 160
                          .|...|.||.|.|:.:...:|  |.|..|:.::|....|..:.....|.|:
Human    69 NFIASVRRRDLANMTGLLHLSLSRNTIRHVAAGAF--ADLRALRALHLDGNRLTSLGEGQLRGLV 131

  Fly   161 NLVELDLSQNLLSAIPSLALYHVSE-LRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIA 224
            ||..|.||.|.|:|:.:.||...:| |.:|.||.|.:.::|.:|.|.:..:..|.|....|:.:.
Human   132 NLRHLILSNNQLAALAAGALDDCAETLEDLDLSYNNLEQLPWEALGRLGNVNTLGLDHNLLASVP 196

  Fly   225 VRAFAGLESSLEWLKLDGNRLSEVRSGTITS----LASLHG-------LELARNTWNCSCSLRPL 278
            ..||:.|. .|..|.:..|||:.:....:.|    ||...|       |....|..:|:|.|..|
Human   197 AGAFSRLH-KLARLDMTSNRLTTIPPDPLFSRLPLLARPRGSPASALVLAFGGNPLHCNCELVWL 260

  Fly   279 RAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGV-EGRNITMSCYVE 342
            |....:.::.:     |.|||.|.||.:..:..::|.|.|.:|...:....| .||...:.|...
Human   261 RRLAREDDLEA-----CASPPALGGRYFWAVGEEEFVCEPPVVTHRSPPLAVPAGRPAALRCRAV 320

  Fly   343 GVPQPAVKWLL-KNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDA 406
            |.|:|.|:|:. :.||:.|.|           |..|...|             .|.:|..:..|.
Human   321 GDPEPRVRWVSPQGRLLGNSS-----------RARAFPNG-------------TLELLVTEPGDG 361

  Fly   407 GIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRK 471
            ||:||.|.|.||:..|:|.|.|...||
Human   362 GIFTCIAANAAGEATAAVELTVGPPPP-------------------------------------- 388

  Fly   472 LRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDN 536
                                      |.|....||                        .|..|.
Human   389 --------------------------PQLANSTSC------------------------DPPRDG 403

  Fly   537 DAGQAAAIVNPSAGSAQRRNGDY-------LHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQ 594
            |..   |:..|||.||..:..|.       :.|:.|    .....|...|.|:|.    |.....
Human   404 DPD---ALTPPSAASASAKVADTGPPTDRGVQVTEH----GATAALVQWPDQRPI----PGIRMY 457

  Fly   595 QHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDI----GGTDSASSSISSQVDAAARLAGYA 655
            |.|....:...:|.......|.....|||...|..|:    ...|||:...:::....||
Human   458 QIQYNSSADDILVYRMIPAESRSFLLTDLASGRTYDLCVLAVYEDSATGLTATRPVGCAR----- 517

  Fly   656 GHTWKTTPIATTKINSPHS 674
               :.|.| |.....:||:
Human   518 ---FSTEP-ALRPCGAPHA 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	49/168 (29%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	21/59 (36%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	18/61 (30%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	6/23 (26%)
		leucine-rich repeat	235..258	CDD:275380	7/26 (27%)
		LRRCT	267..316	CDD:214507	14/48 (29%)
		IG_like	328..428	CDD:214653	30/101 (30%)
		Ig	335..425	CDD:143165	25/90 (28%)
LRFN3	NP_078785.1	LRR_8	59..119	CDD:290566	11/61 (18%)
		LRR 1	60..83		0/22 (0%)
		LRR_RI	<63..168	CDD:238064	30/106 (28%)
		leucine-rich repeat	63..84	CDD:275380	0/20 (0%)
		LRR 2	84..105		7/22 (32%)
		leucine-rich repeat	85..108	CDD:275380	8/24 (33%)
		LRR 3	108..129		3/20 (15%)
		leucine-rich repeat	109..132	CDD:275380	5/22 (23%)
		LRR 4	132..153		10/20 (50%)
		leucine-rich repeat	133..157	CDD:275380	9/23 (39%)
		LRR_8	157..216	CDD:290566	17/59 (29%)
		LRR 5	157..178		7/20 (35%)
		leucine-rich repeat	158..181	CDD:275380	8/22 (36%)
		LRR 6	181..202		5/20 (25%)
		leucine-rich repeat	182..205	CDD:275380	6/23 (26%)
		LRR 7	205..226		5/20 (25%)
		leucine-rich repeat	206..230	CDD:275380	6/23 (26%)
		leucine-rich repeat	242..253	CDD:275378	2/10 (20%)
		TPKR_C2	249..>281	CDD:301599	11/36 (31%)
		IG_like	302..383	CDD:214653	30/104 (29%)
		Ig	310..383	CDD:299845	29/96 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..430		17/138 (12%)
		fn3	424..502	CDD:278470	16/85 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6373
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960