DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and LRFN4

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001350453.1	Gene:	LRFN4 / 78999	HGNCID:	28456	Length:	635	Species:	Homo sapiens

Alignment Length:	430	Identity:	115/430 - (26%)
Similarity:	158/430 - (36%)	Gaps:	120/430 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLI 125
            |||.||...:      |.||..|.|:..|...|.||.:..|..:|..:|..|..|.|:.|.||.:
Human     5 LLLLLLASGA------AACPLPCVCQNLSESLSTLCAHRGLLFVPPNVDRRTVELRLADNFIQAL 63

  Fly   126 -PDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELREL 189
             |.|                           ||.:..||:|.||:|.::.|.:.|...:..||.|
Human    64 GPPD---------------------------FRNMTGLVDLTLSRNAITRIGARAFGDLESLRSL 101

  Fly   190 RLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTIT 254
            .|.||.::.:...:......|..|.||..:|..||..||.....|||.|.|..|.|.:|....|.
Human   102 HLDGNRLVELGTGSLRGPVNLQHLILSGNQLGRIAPGAFDDFLESLEDLDLSYNNLRQVPWAGIG 166

  Fly   255 SLASLHGLEL------------------------------------------------------- 264
            ::.:||.|.|
Human   167 AMPALHTLNLDHNLIDALPPGAFAQLGQLSRLDLTSNRLATLAPDPLFSRGRDAEASPAPLVLSF 231

  Fly   265 ARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHG 329
            :.|..:|:|.|    .|:.:...|..: .||.|||.|:||.:..:...:|:|.|.::|..|....
Human   232 SGNPLHCNCEL----LWLRRLARPDDL-ETCASPPGLAGRYFWAVPEGEFSCEPPLIARHTQRLW 291

  Fly   330 V-EGRNITMSCYVEGVPQPAVKWL-LKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRN 392
            | ||:..|:.|...|.|.|.:.|: ..:||:.|.|           |..|...|
Human   292 VLEGQRATLRCRALGDPAPTMHWVGPDDRLVGNSS-----------RARAFPNG----------- 334

  Fly   393 ASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRP 432
              .|.|......|||.|||.|.|.||:..|.|.|.|...|
Human   335 --TLEIGVTGAGDAGGYTCIATNPAGEATARVELRVLALP 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	46/212 (22%)
		leucine-rich repeat	112..137	CDD:275380	8/25 (32%)
		LRR_8	137..196	CDD:290566	16/58 (28%)
		leucine-rich repeat	138..161	CDD:275380	2/22 (9%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	21/60 (35%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	15/48 (31%)
		IG_like	328..428	CDD:214653	31/101 (31%)
		Ig	335..425	CDD:143165	26/90 (29%)
LRFN4	NP_001350453.1	LRR_8	48..108	CDD:316378	24/86 (28%)
		LRR 1	49..70		9/47 (19%)
		leucine-rich repeat	50..73	CDD:275380	10/49 (20%)
		LRR 2	73..94		8/20 (40%)
		leucine-rich repeat	74..97	CDD:275380	8/22 (36%)
		LRR_8	97..157	CDD:316378	21/59 (36%)
		LRR 3	97..118		6/20 (30%)
		leucine-rich repeat	98..121	CDD:275380	6/22 (27%)
		LRR 4	121..142		9/20 (45%)
		leucine-rich repeat	122..146	CDD:275380	9/23 (39%)
		LRR_8	146..205	CDD:316378	13/58 (22%)
		LRR 5	146..161		7/14 (50%)
		leucine-rich repeat	147..170	CDD:275380	8/22 (36%)
		LRR 6	170..191		4/20 (20%)
		leucine-rich repeat	171..194	CDD:275380	4/22 (18%)
		LRR 7	194..215		0/20 (0%)
		leucine-rich repeat	195..213	CDD:275380	0/17 (0%)
		LRRCT	234..278	CDD:214507	15/48 (31%)
		Ig_2	295..368	CDD:143241	29/96 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	373..410		115/430 (27%)
		fn3	409..478	CDD:306538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..583
		PDZ-binding	632..635
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	127	1.000	Inparanoid score	I4688
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.960