DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and slit3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001072738.1	Gene:	slit3 / 780195	XenbaseID:	XB-GENE-991050	Length:	1519	Species:	Xenopus tropicalis

Alignment Length:	945	Identity:	190/945 - (20%)
Similarity:	319/945 - (33%)	Gaps:	231/945 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSG 119
            ||:...|.||.|...:    |...||:.|.|   || .:|.|....|..:|:.:....:.||:..
Frog    10 LPVVAPLCLWSLLTFA----LVNGCPSKCTC---SG-PNVDCHGLGLKTVPKGIPRNAERLDMDK 66

  Fly   120 NEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVS 184
            |.|..|....|  |.|.||:.::|....:.:|||.||:.|..|..:.|::|.|..:|.|...:.:
Frog    67 NNITRITKTDF--AGLKNLRVLHLEDNQISIIERGAFQDLKQLERMRLNKNKLQVLPELLFQNNA 129

  Fly   185 ELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVR 249
            :|..|.||.|.|..:|..:|..:..:..|:|.:.::|.|....|..|. .||.|.|:.|.::.:.
Frog   130 KLTRLDLSENQIQGLPRKSFRGITDVKNLQLDNNQISCIEDGVFRALR-ELEILTLNNNNITRIP 193

  Fly   250 SGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVD-- 312
            ..:...:..:..|.|..|...|.|.|..|..| |:|....|....|.||..|  |.::..||.
Frog   194 LTSFNHMPKIRTLRLHSNYLYCDCHLTWLSDW-LRQRKTIGQFTFCMSPVHL--RGFNVADVQKK 255

  Fly   313 DFACV-PQIVATDTTAHGVE------GRNITMSCYVEG-------VPQPAVKWLLKNRLIANLSA 363
            ||.|. .|.......|:.|.      ..|..:.|..:|       :|:..::..|:...|..:.|
Frog   256 DFVCPGTQSEPPSCNANAVSCPSACTCSNNVVDCRGKGLTEIPANLPEGIIEIRLEQNSIKAIPA 320

  Fly   364 GGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAV 428
            |            ..|..:|...:::.:|.              |...||:..:|....:..:..
Frog   321 G------------VFTPYKKLKRIDISKNQ--------------ISEIAADAFSGLKSLTSLVLY 359

  Fly   429 SRRPPEAPWGVRIILLGAVA-ALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYE-KIE 491
            ..:..|.|.|   :..|.|: .|||:..:....:.:.:.|..:.|.|.:         .|: |::
Frog   360 GNKITEIPKG---LFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLS---------LYDNKLQ 412

  Fly   492 MTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTP-------------LNDNDAGQAAA 543
            ..::                   |||...:....|..|..|             |.||....:.|
Frog   413 TISK-------------------GLFAPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGA 458

  Fly   544 IVNPSAGSAQRRNGDYLHVSTHCDDEEE-----------------------------DQQLHHHP 579
            ........|.:|..........|...|:                             :|::...|
Frog   459 RCTSPRRLANKRISQIKSKKFRCTGSEDYRSKFSGDCFMDLVCPEKCRCEGTIVDCSNQKISRIP 523

  Fly   580 QQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAP-LEETDLHIPRLIDI--GGTDSASSSI 641
            ...|........|..:..        |:.|:|.....| |.:.:|...::.||  |..|.| :.:
Frog   524 SYLPEYTSDLRLNDNEIT--------VLEATGIFKKLPNLRKINLSNNKIKDIREGAFDGA-AGV 579

  Fly   642 SSQVDAAARLAGYAGHTW------KT----------------TPIATTKINSPHSKPVTSAAP-- 682
            ...:....:|....|..:      ||                |.:::.::.|.:...:|:..|
Frog   580 QELMLTGNQLESVHGRMFRGLVGLKTLMLRSNLMSCINNDTFTGLSSVRLLSLYDNRITTITPGA 644

  Fly   683 -------SSLNTQATPY---AHY--------------GNH-----------PADEMATSVFCSEG 712
                   |::|..:.|:   .|.              ||.           |..::|...|..:|
Frog   645 FNTLVSLSTINLLSNPFNCNCHLAWLGKWLRKKRVVSGNPRCQKPYFLKEIPIQDVAIQDFTCDG 709

  Fly   713 QE--SDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKL--KTSGKYFRNS 773
            .|  |.|..|:.|:.....:..|....|                ||.|||:.:  ..:..|...:
Frog   710 NEESSCLPASHCPEQCTCVESVVRCGNQ----------------GLRTLPKNIPKDVTELYLEGN 758

  Fly   774 SDSQSPLLADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANYSSTATYTGGGQRANSFLNLV 838
            ..:..|   ...|.:...||.|.|  |.::.:...|    :::|.:..:|......|........
Frog   759 HLTSVP---KEISSFKHLTLIDLS--NNSISVLSNY----TFSNVTQLSTLILSYNRLRCIPVHA 814

  Fly   839 QSGAHQGKLLPSHLGQKPSLPSSPVQHQRSLSSAA 873
            .:|....::|..|.....::|........|||..|
Frog   815 FNGLKSLRVLTLHGNDISTVPDGSFSDLTSLSHLA 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	44/156 (28%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	20/58 (34%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	19/60 (32%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	6/23 (26%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	18/50 (36%)
		IG_like	328..428	CDD:214653	16/112 (14%)
		Ig	335..425	CDD:143165	14/96 (15%)
slit3	NP_001072738.1	LRRNT	29..60	CDD:214470	10/34 (29%)
		LRR_8	57..117	CDD:290566	20/61 (33%)
		LRR_4	60..97	CDD:289563	11/38 (29%)
		leucine-rich repeat	60..82	CDD:275380	8/23 (35%)
		LRR_RI	<83..216	CDD:238064	36/133 (27%)
		leucine-rich repeat	83..106	CDD:275380	8/22 (36%)
		LRR_8	105..165	CDD:290566	16/59 (27%)
		leucine-rich repeat	107..130	CDD:275380	6/22 (27%)
		leucine-rich repeat	131..154	CDD:275380	8/22 (36%)
		LRR_8	155..213	CDD:290566	14/58 (24%)
		leucine-rich repeat	155..178	CDD:275380	6/23 (26%)
		leucine-rich repeat	179..202	CDD:275380	5/22 (23%)
		leucine-rich repeat	203..305	CDD:275380	28/104 (27%)
		TPKR_C2	211..260	CDD:301599	18/51 (35%)
		LRRNT	276..307	CDD:214470	4/30 (13%)
		LRR_8	307..363	CDD:290566	11/81 (14%)
		leucine-rich repeat	307..328	CDD:275380	5/32 (16%)
		LRR_4	327..367	CDD:289563	7/53 (13%)
		leucine-rich repeat	329..352	CDD:275380	5/36 (14%)
		LRR_8	351..435	CDD:290566	18/114 (16%)
		leucine-rich repeat	353..373	CDD:275380	3/22 (14%)
		leucine-rich repeat	377..400	CDD:275380	4/22 (18%)
		leucine-rich repeat	401..422	CDD:275380	7/48 (15%)
		leucine-rich repeat	425..516	CDD:275380	11/90 (12%)
		TPKR_C2	433..>463	CDD:301599	5/29 (17%)
		LRRNT	501..531	CDD:214470	3/29 (10%)
		LRR_4	533..570	CDD:289563	9/44 (20%)
		leucine-rich repeat	533..554	CDD:275380	4/28 (14%)
		LRR_8	553..613	CDD:290566	12/60 (20%)
		leucine-rich repeat	555..578	CDD:275380	7/23 (30%)
		leucine-rich repeat	579..602	CDD:275380	2/22 (9%)
		LRR_8	602..661	CDD:290566	8/58 (14%)
		leucine-rich repeat	603..626	CDD:275380	3/22 (14%)
		leucine-rich repeat	627..650	CDD:275380	3/22 (14%)
		leucine-rich repeat	651..741	CDD:275380	19/105 (18%)
		LRRCT	659..708	CDD:214507	7/48 (15%)
		LRRNT	720..752	CDD:214470	8/47 (17%)
		leucine-rich repeat	742..772	CDD:275380	5/32 (16%)
		LRR_8	771..831	CDD:290566	12/65 (18%)
		leucine-rich repeat	773..796	CDD:275380	7/28 (25%)
		LRR_4	795..836	CDD:289563	5/40 (13%)
		leucine-rich repeat	797..820	CDD:275380	3/22 (14%)
		leucine-rich repeat	821..842	CDD:275380	3/20 (15%)
		LRRCT	853..902	CDD:214507
		EGF	916..947	CDD:278437
		EGF_CA	952..989	CDD:238011
		EGF_CA	994..1027	CDD:238011
		EGF_CA	1031..1068	CDD:238011
		EGF_CA	1070..1106	CDD:238011
		LamG	1155..1308	CDD:238058
		GHB_like	1454..1517	CDD:304424
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910