DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lrrtm2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001102939.1	Gene:	Lrrtm2 / 685472	RGDID:	1593785	Length:	515	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	107/525 - (20%)
Similarity:	165/525 - (31%)	Gaps:	179/525 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQ-- 134
            |..|...||..|.|:    |....|.:.....:|...|.|:..|.|..|.|..:..|.||:..
  Rat    27 LPALGMACPPKCRCE----KLLFYCDSQGFHSVPNATDKGSLGLSLRHNHITALERDQFASFSQL 87

  Fly   135 --------------------LLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLA 179
                                |..|:::.|:...:..:....|.:||||..||||.|.||::....
  Rat    88 TWLHLDHNQISTVKEDAFQGLYKLKELILSSNKIFYLPNTTFTQLINLQNLDLSFNQLSSLHPEL 152

  Fly   180 LYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAG-------------- 230
            .|.:.:|:.|.|..|.:..:|...|.....|..|:||..||..:|...|||
  Rat   153 FYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTNRLRSLARNGFAGLIKLRELHLEHNQL 217

  Fly   231 --------------------------LESSLEW-------------------------------L 238
                                      |...:||                               |
  Rat   218 TKINFAHFLRLSSLHTLFLQWNKISNLTCGMEWTWSTLEKLDLTGNEIKAIDLTVFETMPNLKIL 282

  Fly   239 KLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWM--LQQNIPSGIPPTCESPPRL 301
            .:|.|:|:.:.|..::||.||..:.|:.|.|.||..:..|.:|:  .|......|  .|.||...
  Rat   283 LMDNNKLNSLDSKILSSLRSLTTVGLSGNLWECSPRVCALASWLGSFQGRWEHSI--LCHSPDHT 345

  Fly   302 SGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGD 366
            .|.  |.||               ..||.:                         |..|||.
  Rat   346 QGE--DILD---------------AVHGFQ-------------------------LCWNLST--- 365

  Fly   367 GDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRR 431
                  ..||.||..|..        .:..|.:::.....|       :|.....|.:.:.....
  Rat   366 ------TVTAMATTYRDP--------TTEYTKISSSSYHVG-------DKEIPTTAGIAVTTEEH 409

  Fly   432 PPEAPWGV--RIILLGAVAALLLVGGSSFAAICLCSLQRR------RKLRLWNSVPPVRRSESYE 488
            .||....:  :.::.|.:|.|.    |.|..|.:..:.|:      |::|..:.:...|:..|..
  Rat   410 FPEPDNAIFTQRVITGTMALLF----SFFFIIFIVFISRKCCPPTLRRIRQCSMIQNHRQLRSQT 470

  Fly   489 KIEMT 493
            ::.|:
  Rat   471 RLHMS 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	53/249 (21%)
		leucine-rich repeat	112..137	CDD:275380	8/46 (17%)
		LRR_8	137..196	CDD:290566	19/58 (33%)
		leucine-rich repeat	138..161	CDD:275380	4/22 (18%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	22/131 (17%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	11/63 (17%)
		leucine-rich repeat	235..258	CDD:275380	9/53 (17%)
		LRRCT	267..316	CDD:214507	15/50 (30%)
		IG_like	328..428	CDD:214653	15/99 (15%)
		Ig	335..425	CDD:143165	13/89 (15%)
Lrrtm2	NP_001102939.1	LRR 1	61..83		7/21 (33%)
		leucine-rich repeat	66..86	CDD:275380	7/19 (37%)
		LRR_RI	73..311	CDD:238064	49/237 (21%)
		LRR 2	84..107		0/22 (0%)
		LRR_8	85..145	CDD:290566	13/59 (22%)
		leucine-rich repeat	87..110	CDD:275380	1/22 (5%)
		LRR 3	109..131		3/21 (14%)
		leucine-rich repeat	111..134	CDD:275380	4/22 (18%)
		LRR 4	132..155		11/22 (50%)
		LRR_8	134..193	CDD:290566	20/58 (34%)
		leucine-rich repeat	135..158	CDD:275380	9/22 (41%)
		LRR 5	156..179		6/22 (27%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR_8	181..241	CDD:290566	10/59 (17%)
		LRR 6	181..203		8/21 (38%)
		leucine-rich repeat	183..206	CDD:275380	10/22 (45%)
		LRR 7	205..227		0/21 (0%)
		leucine-rich repeat	207..230	CDD:275380	0/22 (0%)
		LRR 8	229..251		2/21 (10%)
		leucine-rich repeat	231..254	CDD:275380	3/22 (14%)
		LRR 9	252..275		0/22 (0%)
		LRR_8	253..312	CDD:290566	10/58 (17%)
		leucine-rich repeat	255..278	CDD:275380	0/22 (0%)
		LRR 10	276..299		5/22 (23%)
		leucine-rich repeat	279..300	CDD:275380	5/20 (25%)
		Involved in DLG4-binding	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334952
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930