DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and lgi2a

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001034730.1	Gene:	lgi2a / 654827	ZFINID:	ZDB-GENE-060217-2	Length:	536	Species:	Danio rerio

Alignment Length:	287	Identity:	62/287 - (21%)
Similarity:	115/287 - (40%)	Gaps:	71/287 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LLLW-LLCCCSQLGQLRA---ECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNE 121
            :::| ||...:.||....   :||:.|.|    .|||::|:.:  :::|
Zfish     5 VIIWALLLYLAPLGNTAKKAFKCPSSCSC----SKESIICVGS--SYVP---------------- 47

  Fly   122 IQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSEL 186
             :.||:|..:.:                         ::|....::.:.:.|.:|||.|
Zfish    48 -RYIPNDVSSLS-------------------------IVNGTFSEVKEAMFSHMPSLQL------ 80

  Fly   187 RELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSG 251
              |.|:.|.:..|.||||..:|.|..|.:.:.::...:..:|.||. .|..|.|..|.:..:...
Zfish    81 --LLLNSNALTTVRDDAFSGLPHLEYLFIENNKIETTSKYSFRGLR-DLTHLSLANNNIKALPRE 142

  Fly   252 TITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIP-SGIPPTCESPPRLSGRAWDKLDVDDFA 315
            ....|.||..|:|..|.:.|.|..:.|..|:...|.. |.:  .|..|..:.|:.     ::|.|
Zfish   143 LFIDLDSLIELDLRGNVFECDCRAKWLMMWLKSTNATVSDV--LCAGPEEMKGKR-----LNDMA 200

  Fly   316 CV-PQIVATD-TTAHGVEGRNITMSCY 340
            .: .:.::|| ...|.|...::::..:
Zfish   201 SLHNECISTDFIPLHSVPTESLSVDTF 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	32/156 (21%)
		leucine-rich repeat	112..137	CDD:275380	3/24 (13%)
		LRR_8	137..196	CDD:290566	9/58 (16%)
		leucine-rich repeat	138..161	CDD:275380	0/22 (0%)
		leucine-rich repeat	162..185	CDD:275380	5/22 (23%)
		LRR_8	184..245	CDD:290566	18/60 (30%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	5/23 (22%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	11/49 (22%)
		IG_like	328..428	CDD:214653	2/13 (15%)
		Ig	335..425	CDD:143165	0/6 (0%)
lgi2a	NP_001034730.1	LRR_8	54..112	CDD:290566	17/90 (19%)
		LRR_8	100..158	CDD:290566	15/58 (26%)
		LRR_4	100..140	CDD:289563	10/40 (25%)
		leucine-rich repeat	102..125	CDD:275378	5/23 (22%)
		LRR_4	126..>158	CDD:289563	9/31 (29%)
		leucine-rich repeat	126..149	CDD:275378	5/22 (23%)
		leucine-rich repeat	150..162	CDD:275378	4/11 (36%)
		LRRCT	158..198	CDD:214507	10/46 (22%)
		EPTP	210..251	CDD:281697	3/18 (17%)
		EPTP	257..297	CDD:281697
		EPTP	302..348	CDD:281697
		EPTP	351..393	CDD:281697
		EPTP	398..439	CDD:281697
		EPTP	443..484	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840