DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and LINGO3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001094861.1	Gene:	LINGO3 / 645191	HGNCID:	21206	Length:	592	Species:	Homo sapiens

Alignment Length:	610	Identity:	142/610 - (23%)
Similarity:	206/610 - (33%)	Gaps:	227/610 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLS------------------------- 118
            |||.|||..::  .:|.|....||.:|..:.|.|:||:||
Human    25 CPARCECTVQT--RAVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSE 87

  Fly   119 -----------------------GNEIQLIPDDSF------------------------------ 130
                                   ||:::|||...|
Human    88 NAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSL 152

  Fly   131 ----------------ATAQLLNLQKVYLARC-----------HLR-------------LIERHA 155
                            |.|.||.|:::.|.||           |||             .:|...
Human   153 RRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQN 217

  Fly   156 FRKL------------------------INLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPI 196
            ||:|                        :||..|.::...::|:|:.||.|.:.|..|.||.|||
Human   218 FRRLPGLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPI 282

  Fly   197 LRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHG 261
            ..||..:|..:.:|.:|.|:...|:.:..:||.||. .:..|.|..|.||.:...|..|:.:|..
Human   283 STVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLR-QIRLLNLSNNLLSTLEESTFHSVNTLET 346

  Fly   262 LELARNTWNCSCSLRPLRAWMLQQNIP---SGIPPTCESPPRLSGRAW----DKLDVDDFAC--- 316
            |.:..|...|.|.|    .|::|:...   .|..|.|.:|..:.|.|.    |.:..:.|.|
Human   347 LRVDGNPLACDCRL----LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEYFVCRKP 407

  Fly   317 ------VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLL-KNRLIANLSAGGDGDSDSEPR 374
                  :.::.||       .|.::...|..||.|.|.|.|:. ::|.:...|||
Human   408 KIRERRLQRVTAT-------AGEDVRFLCRAEGEPAPTVAWVTPQHRPVTATSAG---------- 455

  Fly   375 TAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTL------AVSRRPP 433
            .|....|            ..|.|..|..||:|.|||.|.|..|......||      |.:|.|.
Human   456 RARVLPG------------GTLEIQDARPQDSGTYTCVASNAGGNDTYFATLTVRPEPAANRTPG 508

  Fly   434 E----------APWGVRIILLG-AVAALLLVGGSSFAAICLCSLQRRRKLRLWN-SVPPVRRSES 486
            |          ||..:..||:. |:..:..:|...|..:.|....|.|.....| ||     ..|
Human   509 EAHNETLAALRAPLDLTTILVSTAMGCITFLGVVLFCFVLLFVWSRGRGQHKNNFSV-----EYS 568

  Fly   487 YEKIEMTARTRPDLGGGASCGGGSA 511
            :.|::         |..|:.|.|.|
Human   569 FRKVD---------GPAAAAGQGGA 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	62/298 (21%)
		leucine-rich repeat	112..137	CDD:275380	14/118 (12%)
		LRR_8	137..196	CDD:290566	24/106 (23%)
		leucine-rich repeat	138..161	CDD:275380	11/70 (16%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	21/60 (35%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		LRRCT	267..316	CDD:214507	14/55 (25%)
		IG_like	328..428	CDD:214653	28/106 (26%)
		Ig	335..425	CDD:143165	25/90 (28%)
LINGO3	NP_001094861.1	LRRNT	24..58	CDD:214470	13/34 (38%)
		LRR 1	55..76		5/20 (25%)
		LRR_8	57..138	CDD:290566	10/80 (13%)
		LRR_4	59..95	CDD:289563	3/35 (9%)
		leucine-rich repeat	59..79	CDD:275380	3/19 (16%)
		LRR 2	79..100		0/20 (0%)
		leucine-rich repeat	80..103	CDD:275380	0/22 (0%)
		LRR 3	103..124		6/20 (30%)
		leucine-rich repeat	104..127	CDD:275380	6/22 (27%)
		LRR_RI	111..>286	CDD:238064	36/174 (21%)
		LRR_8	127..>172	CDD:290566	1/44 (2%)
		LRR 4	127..148		0/20 (0%)
		leucine-rich repeat	128..151	CDD:275380	0/22 (0%)
		LRR 5	151..172		1/20 (5%)
		leucine-rich repeat	152..199	CDD:275380	10/46 (22%)
		LRR 6	175..196		4/20 (20%)
		LRR_8	198..258	CDD:290566	8/59 (14%)
		leucine-rich repeat	200..223	CDD:275380	4/22 (18%)
		LRR 7	207..228		4/20 (20%)
		leucine-rich repeat	224..247	CDD:275380	0/22 (0%)
		LRR_8	247..303	CDD:290566	21/55 (38%)
		LRR 8	247..268		7/20 (35%)
		leucine-rich repeat	248..271	CDD:275380	7/22 (32%)
		LRR 9	271..292		10/20 (50%)
		leucine-rich repeat	272..293	CDD:275380	10/20 (50%)
		LRR 10	295..316		6/20 (30%)
		leucine-rich repeat	296..319	CDD:275380	8/23 (35%)
		LRR 11	319..340		6/20 (30%)
		leucine-rich repeat	322..343	CDD:275380	7/20 (35%)
		I-set	407..497	CDD:254352	30/118 (25%)
		Ig	422..490	CDD:299845	26/89 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910