DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment kek3 and LRRC4

DIOPT Version :9

Sequence 1:NP_001162986.1 Gene:kek3 / 34912 FlyBaseID:FBgn0028370 Length:1021 Species:Drosophila melanogaster
Sequence 2:NP_071426.1 Gene:LRRC4 / 64101 HGNCID:15586 Length:653 Species:Homo sapiens


Alignment Length:685 Identity:166/685 - (24%)
Similarity:248/685 - (36%) Gaps:214/685 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 LP-LHLHLLLWLLC----CCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQL 114
            || ::|...:|:||    ..:..|.  ..||:||.|..:..|  |:|....|:.:||.:.:.|:.
Human    19 LPFVYLTAQVWILCAAIAAAASAGP--QNCPSVCSCSNQFSK--VVCTRRGLSEVPQGIPSNTRY 79

  Fly   115 LDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLA 179
            |:|..|.||:|..|:|  ..|.:|:.:.|.|..:|.||..||..|.:|..|:|..|.|:.|||.|
Human    80 LNLMENNIQMIQADTF--RHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGA 142

  Fly   180 LYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDC-RLSHIAVRAFAGLES---------- 233
            ..::|:||||.|..|||..:|..||..||.|::|:|.:. :|.:|:..||.||.:          
Human   143 FEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGLFNLKYLNLGMCN 207

  Fly   234 -----------SLEWLKLDGNRLSEVRSGTITSLASL---------------------------- 259
                       .||.|::.||...|:|.|:...|:||                            
Human   208 IKDMPNLTPLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWVMNSQVSLIERNAFDGLASLVELN 272

  Fly   260 --HG------------------LELARNTWNCSCSLRPLRAWMLQQNIP--SGIPPTCESPPRLS 302
              |.                  |.|..|.|||.|.:..| ||.|::.||  |.....|.:|..:.
Human   273 LAHNNLSSLPHDLFTPLRYLVELHLHHNPWNCDCDILWL-AWWLREYIPTNSTCCGRCHAPMHMR 336

  Fly   303 GRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGD 366
            ||...::|...|.| .|.|:......:..|||...:.|...  |..:|||||.|..:.:      
Human   337 GRYLVEVDQASFQCSAPFIMDAPRDLNISEGRMAELKCRTP--PMSSVKWLLPNGTVLS------ 393

  Fly   367 GDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEAS-------- 423
             .:...||.:....|        ..|.|::.     :.|.|:|||...|.||...||        
Human   394 -HASRHPRISVLNDG--------TLNFSHVL-----LSDTGVYTCMVTNVAGNSNASAYLNVSTA 444

  Fly   424 ------------VTLAVSRRPPE--------------------------------APWGVRI--- 441
                        ||:..:...||                                .|..|.:   
Human   445 ELNTSNYSFFTTVTVETTEISPEDTTRKYKPVPTTSTGYQPAYTTSTTVLIQTTRVPKQVAVPAT 509

  Fly   442 ------------------ILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYE 488
                              |::|...|:.|:     ||..|....:.||.....|.....|:....
Human   510 DTTDKMQTSLDEVMKTTKIIIGCFVAVTLL-----AAAMLIVFYKLRKRHQQRSTVTAARTVEII 569

  Fly   489 KIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQ 553
            :::............|:..|.|..||.:         |...|..:|.|       ...|:.|:..
Human   570 QVDEDIPAATSAAATAAPSGVSGEGAVV---------LPTIHDHINYN-------TYKPAHGAHW 618

  Fly   554 RRN--GDYLH-----------VSTHCDDEEEDQQL 575
            ..|  |:.||           :.||..|:.::.|:
Human   619 TENSLGNSLHPTVTTISEPYIIQTHTKDKVQETQI 653

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
kek3NP_001162986.1 LRR_RI <110..267 CDD:238064 65/226 (29%)
leucine-rich repeat 112..137 CDD:275380 10/24 (42%)
LRR_8 137..196 CDD:290566 25/58 (43%)
leucine-rich repeat 138..161 CDD:275380 9/22 (41%)
leucine-rich repeat 162..185 CDD:275380 9/22 (41%)
LRR_8 184..245 CDD:290566 28/82 (34%)
leucine-rich repeat 186..209 CDD:275380 12/22 (55%)
leucine-rich repeat 210..234 CDD:275380 9/45 (20%)
leucine-rich repeat 235..258 CDD:275380 9/22 (41%)
LRRCT 267..316 CDD:214507 18/50 (36%)
IG_like 328..428 CDD:214653 28/119 (24%)
Ig 335..425 CDD:143165 23/109 (21%)
LRRC4NP_071426.1 LRRNT 46..79 CDD:214470 12/34 (35%)
LRR <74..291 CDD:227223 63/218 (29%)
LRR 1 76..97 9/22 (41%)
leucine-rich repeat 77..100 CDD:275380 10/24 (42%)
LRR 2 100..121 8/20 (40%)
leucine-rich repeat 101..124 CDD:275380 9/22 (41%)
LRR 3 124..145 9/20 (45%)
leucine-rich repeat 125..148 CDD:275380 9/22 (41%)
LRR 4 148..169 11/20 (55%)
leucine-rich repeat 149..172 CDD:275380 12/22 (55%)
LRR 5 172..194 7/21 (33%)
leucine-rich repeat 173..197 CDD:275380 9/23 (39%)
LRR 6 197..218 0/20 (0%)
leucine-rich repeat 198..219 CDD:275380 0/20 (0%)
LRR 7 219..240 8/20 (40%)
leucine-rich repeat 220..243 CDD:275380 9/22 (41%)
LRR 8 243..264 2/20 (10%)
leucine-rich repeat 244..267 CDD:275380 1/22 (5%)
LRR 9 267..288 1/20 (5%)
leucine-rich repeat 268..289 CDD:275380 1/20 (5%)
LRRCT 300..351 CDD:214507 18/51 (35%)
IG 359..441 CDD:214652 26/103 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41933
orthoMCL 1 0.900 - - OOG6_104601
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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