DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and LRRC4C

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001245348.1	Gene:	LRRC4C / 57689	HGNCID:	29317	Length:	640	Species:	Homo sapiens

Alignment Length:	710	Identity:	180/710 - (25%)
Similarity:	271/710 - (38%)	Gaps:	195/710 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 GPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAE-CPAVCECKWKSGKESVLCLNANLTH 103
            |||..|.|..||     |.:.|.|.||...   |.:||: ||:||.|..:..|  |:|:..||..
Human    15 GPRFNRALFDPL-----LVVLLALQLLVVA---GLVRAQTCPSVCSCSNQFSK--VICVRKNLRE 69

  Fly   104 IPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLS 168
            :|..:...|:||:|..|:||:|..:||  ..|.:|:.:.|:|.|:|.||..||..|.||..|:|.
Human    70 VPDGISTNTRLLNLHENQIQIIKVNSF--KHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELF 132

  Fly   169 QNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDC-RLSHIAVRAFAGLE 232
            .|.|:.||:.|..::|:|:||.|..|||..:|..||..:|.|.:|:|.:. |||:|:..||.||.
Human   133 DNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLS 197

  Fly   233 S---------------------SLEWLKLDGNRLSEVRSGTITSL-------------------- 256
            :                     .|:.|.|.||.||.:|.|:...|
Human   198 NLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNA 262

  Fly   257 -------------------------ASLHGLE---LARNTWNCSCSLRPLRAWMLQQNIPSGIP- 292
                                     ..||.||   |..|.|||:|.:..| :|.::...||...
Human   263 FDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWL-SWWIKDMAPSNTAC 326

  Fly   293 -PTCESPPRLSGRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKN 355
             ..|.:||.|.||...:||.:.|.| .|.||......:..||....:.|.. .....:|.|:..|
Human   327 CARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRA-STSLTSVSWITPN 390

  Fly   356 RLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKV 420
            ..:....|       .:.|.|..:.|        ..|.:|:|:     ||.|:|||...|..|..
Human   391 GTVMTHGA-------YKVRIAVLSDG--------TLNFTNVTV-----QDTGMYTCMVSNSVGNT 435

  Fly   421 EASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQ-RRRKLRLW-NSVPPV-- 481
            .||.||.|:                   |......|.|:.:.:.::: .:.:.|.. |:|.|.
Human   436 TASATLNVT-------------------AATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPV 481

  Fly   482 --------------RRSESYEKI----------------EMTARTRPDLGGGASCGGGSATGAGL 516
                          :.:.|.||.                |:...|:..:|...:....:|....:
Human   482 VDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTKIIIGCFVAITLMAAVMLVI 546

  Fly   517 FHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDE-EEDQQLHHHPQ 580
            |:...:|.:.:..|.|.      :...|:|                   .||| ..|..:..| .
Human   547 FYKMRKQHHRQNHHAPT------RTVEIIN-------------------VDDEITGDTPMESH-L 585

  Fly   581 QQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASSS 640
            ..||.:|. |.|  .:...|....|..:.:..|:.    .:.:|.|.||.:...|:...:
Human   586 PMPAIEHE-HLN--HYNSYKSPFNHTTTVNTINSI----HSSVHEPLLIRMNSKDNVQET 638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	68/226 (30%)
		leucine-rich repeat	112..137	CDD:275380	11/24 (46%)
		LRR_8	137..196	CDD:290566	25/58 (43%)
		leucine-rich repeat	138..161	CDD:275380	10/22 (45%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	28/82 (34%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	11/45 (24%)
		leucine-rich repeat	235..258	CDD:275380	10/67 (15%)
		LRRCT	267..316	CDD:214507	18/50 (36%)
		IG_like	328..428	CDD:214653	25/99 (25%)
		Ig	335..425	CDD:143165	21/89 (24%)
LRRC4C	NP_001245348.1	LRRNT	47..80	CDD:214470	12/34 (35%)
		PPP1R42	65..235	CDD:411060	63/171 (37%)
		LRR 1	77..98		10/22 (45%)
		leucine-rich repeat	78..101	CDD:275380	11/24 (46%)
		LRR 2	101..122		9/20 (45%)
		leucine-rich repeat	102..125	CDD:275380	10/22 (45%)
		LRR 3	125..146		9/20 (45%)
		leucine-rich repeat	126..149	CDD:275380	8/22 (36%)
		LRR 4	149..170		10/20 (50%)
		leucine-rich repeat	150..173	CDD:275380	10/22 (45%)
		LRR 5	173..195		9/21 (43%)
		leucine-rich repeat	174..198	CDD:275380	11/23 (48%)
		LRR 6	198..219		0/20 (0%)
		leucine-rich repeat	199..220	CDD:275380	0/20 (0%)
		LRR_8	220..279	CDD:404697	10/58 (17%)
		LRR 7	220..241		9/20 (45%)
		leucine-rich repeat	221..244	CDD:275380	10/22 (45%)
		LRR 8	244..265		0/20 (0%)
		leucine-rich repeat	245..268	CDD:275380	0/22 (0%)
		LRR_8	267..>301	CDD:404697	5/33 (15%)
		LRR 9	268..289		0/20 (0%)
		leucine-rich repeat	269..290	CDD:275380	0/20 (0%)
		LRRCT	301..>339	CDD:214507	13/38 (34%)
		IG	360..443	CDD:214652	25/103 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..483		4/19 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BEYA
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41933
orthoMCL	1	0.900	-	-		OOG6_104601
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5308
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740