DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Fili

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001369108.1	Gene:	Fili / 5740472	FlyBaseID:	FBgn0085397	Length:	789	Species:	Drosophila melanogaster

Alignment Length:	811	Identity:	163/811 - (20%)
Similarity:	261/811 - (32%)	Gaps:	276/811 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDA 110
            |..|.|...:|:.|.|||.|:....   :..|.||:.|:|.........||::|.|..:|..|:.
  Fly    12 RSRPWLCGAIPVLLLLLLTLVILPP---ETTAFCPSKCQCLGGEANSRALCVDAALEDVPIQLNP 73

  Fly   111 GT-----------------------QLLDLSGNEIQLIPDDSF---ATAQLLNLQKVYLARCHLR 149
            .|                       ::||||.|.|:.:...:|   :..:.|||.:..::..|
  Fly    74 ETKYINLTVNRIRTLEFSLPFYMKLEILDLSQNIIETLGSKNFEYQSELRTLNLSRNLVSSLH-- 136

  Fly   150 LIERHAFRKLINLVELDLS---------------------------------------------- 168
               :|||:.|.||:.||||
  Fly   137 ---KHAFKGLTNLLLLDLSFNRIETVHPTALSDLASLVELDLTNNNIVSLEDNCFKGMNTLEVLV 198

  Fly   169 --QNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGL 231
              .|.|..:|:..|:|:..|:.|.:|.|.:..|.:|:|..:.:|:.|.:....:|.:.:.||.||
  Fly   199 FRNNRLLDVPASNLWHLHALKSLDMSLNLVEFVRNDSFEGLKELLALSVQGNVMSELDLSAFEGL 263

  Fly   232 -----------------------ESSLEWLKLDGNRLSEVRSGTITSLASLHGLELAR------- 266
                                   .|:|.:|.|.|||.|::.:....:|..|..|.|:|
  Fly   264 ISLKHLDLSDNNLTMVPTQQLSKLSNLTYLNLGGNRFSQLPAVAFLNLFHLRELHLSRLDFLQRI 328

  Fly   267 ----------------------------------------------------------------- 266

  Fly   329 DSRAFVDNTHLQTLHLNNNPQLSDIPMRLFQGNPNILEVYMQSNSLQTLYSAQFPVDQLQKLYLG 393

  Fly   267 -NTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKL--DVDDFACVPQIVATDTTAH 328
             |...|:|||  |..|.|......|:.|..|   ..:|.|...|  :.||.....:..|..:|..
  Fly   394 DNPLQCNCSL--LWLWRLVTGNFEGVDPGME---HAAGGAVAALAKEADDEELADEATAVASTDD 453

  Fly   329 GVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNA 393
            ||    ..::.|:            ..:.|.|               |..|.....|.:....:.
  Fly   454 GV----AALAAYI------------AEQHIVN---------------ALHTTEPSAYELATSSSN 487

  Fly   394 SNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSF 458
            .|..||..|.|..|   |.......:....: |.:|......|..:..::...:..||:......
  Fly   488 RNSGILRMDRQQIG---CDIWRDKVRTRRKL-LTMSEGEITCPAHIVTVVCAVITCLLVAMIGIS 548

  Fly   459 AAICLCSLQRRRKLRLWNSVPPVRRSES----YEKIEMTARTRPDLGGGASC---GGGSATGAGL 516
            ....|..::||||  |.:...|:|.|:|    :::| :.......||.|.|.   ||....|.|:
  Fly   549 VLYYLRFVKRRRK--LLHERGPMRTSKSIINVHDRI-LQGHNPGGLGLGMSMTLGGGNHVNGLGM 610

  Fly   517 F----HDAEEQGYLRAAH-----TPL-----NDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCD 567
            .    |.|:.   |:|.|     .||     |.|...|...:........:|    ||...|..:
  Fly   611 TLNYPHHAQT---LQAHHHYHQAMPLQSHGGNGNHEYQQTTLPQLDKLELER----YLAAQTIAN 668

  Fly   568 D------------EEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSA---- 616
            :            |.:|:..|.:.:    ..|:.:|:  .|...|..|  ..|.:.:|:||
  Fly   669 EYRALKPWELPVKEADDEPEHLYER----FDHYEYPD--THTMSKLKQ--AASLNHSNSSAGPSP 725

  Fly   617 -PLEETDLHIPRLIDIGGTDSASSSISSQVD 646
             |......|:..: ...||....|.|::.::
  Fly   726 VPPSSGKPHVVYVXRGRGTGERVSQINTDIE 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	54/326 (17%)
		leucine-rich repeat	112..137	CDD:275380	8/50 (16%)
		LRR_8	137..196	CDD:290566	22/106 (21%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	10/70 (14%)
		LRR_8	184..245	CDD:290566	20/83 (24%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	7/46 (15%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	16/50 (32%)
		IG_like	328..428	CDD:214653	16/99 (16%)
		Ig	335..425	CDD:143165	13/89 (15%)
Fili	NP_001369108.1	leucine-rich repeat	75..97	CDD:275378	1/21 (5%)
		leucine-rich repeat	98..121	CDD:275380	7/22 (32%)
		LRR_8	120..180	CDD:404697	14/64 (22%)
		leucine-rich repeat	122..145	CDD:275380	8/27 (30%)
		leucine-rich repeat	146..169	CDD:275380	5/22 (23%)
		LRR	<161..>354	CDD:227223	32/192 (17%)
		leucine-rich repeat	170..193	CDD:275380	0/22 (0%)
		leucine-rich repeat	194..217	CDD:275380	5/22 (23%)
		leucine-rich repeat	218..265	CDD:275380	14/46 (30%)
		leucine-rich repeat	266..289	CDD:275380	0/22 (0%)
		leucine-rich repeat	290..313	CDD:275380	8/22 (36%)
		leucine-rich repeat	314..338	CDD:275380	4/23 (17%)
		LRR_8	337..397	CDD:404697	1/59 (2%)
		leucine-rich repeat	339..360	CDD:275380	0/20 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910