DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrig2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_021332954.1	Gene:	lrig2 / 571101	ZFINID:	ZDB-GENE-041111-75	Length:	1044	Species:	Danio rerio

Alignment Length:	927	Identity:	182/927 - (19%)
Similarity:	297/927 - (32%)	Gaps:	331/927 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 LLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIE----------------RHAFRKLI-- 160
            :|.::.|.:.|:||..|..:|   ||.:.|.|..:|::|                |:...||:
Zfish   154 VLKINQNRLSLLPDKVFTLSQ---LQVLELRRNRIRVVESLIFKELKALKSLKMQRNGITKLMDG 215

  Fly   161 ------NLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCR 219
                  |:.||:|..|.|:.:....||.:..||.||::.|.|..:..||:....:|.:|:||...
Zfish   216 ALFGLENMEELELEYNNLTELNKGWLYGLHMLRILRVNQNNIGLIRADAWEFCHRLEELDLSFNH 280

  Fly   220 LSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLAS-------------------------- 258
            ||.:....|||| |.|:.|.|..|::|.:..|..:|||:
Zfish   281 LSRLEDWVFAGL-SLLQSLNLGDNQISHLGEGVFSSLANVRTLDIRNNEISLAIEDFIGMFVGLK 344

  Fly   259 -------------------------LHGLELARN-----------------------TWNCSCSL 275
                                     |..|:|::|                       :..|.|.|
Zfish   345 RLNSLVLQNNKIRTITKRAFEGLMELENLDLSKNGIMSIHPDAFTHLKLKTLDLNSSSLLCDCQL 409

  Fly   276 RPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFAC----VPQIVATDTTAHGVEGRNIT 336
            :.|..|::...........|..|..|:|.:...:..::|.|    .|||.|...||..:.|.|:|
Zfish   410 QWLGQWLINSRFQQSCTAVCAHPASLAGSSVLAVKPEEFVCSDFPKPQITAHPKTAVALRGTNVT 474

  Fly   337 MSCYV--------------------------------------------------EGVPQ----- 346
            ::|..                                                  ||..|
Zfish   475 LNCSAFSSSDSPMSTAWRKDGEVLYEAQVQNYARYQDQRLLYTTILHLLNVNFTDEGQYQCVLSN 539

  Fly   347 ------PAVKWLLKNRL----------------IANLSAGGDG--------DSDSEPRTAAATQG 381
                  ..:..|..|.|                :|.|....:|        ..|......||.:.
Zfish   540 HFGSNYSTLAKLTVNELPTFLKTPMDLTIRTGTVARLECAAEGHPTPQIAWQKDGGINFPAARER 604

  Fly   382 RKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVSRRPP-EAPWGVRIILLG 445
            |    ::::.:.....|.....:|.|:|:|.|:|:||.:.|:.||.|...|. :.|...|.:..|
Zfish   605 R----MHVMPDDDTFFIANVKAEDMGVYSCTAKNEAGSLSANATLTVLETPSFQRPLEDRNVARG 665

  Fly   446 AVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESY-----EKIEMTARTRPDLGGGAS 505
            ..|.|..:...|.|.          :|.......|:..:|.:     .::.:.....|...|..:
Zfish   666 ETAVLQCIARGSPAP----------RLNWTKDDAPLVLTERHFFAAANQLLIIVDAGPADAGKYT 720

  Fly   506 CGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAA--------------AIVNPSAGSA---- 552
            |...:..|.       |:|::..:.:|..:.|.|.:.              .:|....|::
Zfish   721 CIMSNTLGT-------ERGHIYLSVSPSANCDPGSSVYGHDGWTTVGIVVMVVVCCVVGTSLVWV 778

  Fly   553 ------QRRNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASG 611
                  :|::.||...:|   ||          ...||.  .|.....|....:..:|:..|.:|
Zfish   779 IVIYHMRRKSEDYSITNT---DE----------MNLPAD--IPSYLSSQGTLSEPQEGYSNSENG 828

  Fly   612 ANNSAPLEETDLHIPRLIDIGGTDSAS-SSISSQVDAAAR-LAG------YAGHTWKTTPIATTK 668
            ::........:.:|.:     |||... ..:||.||..|. :.|      :|||
Zfish   829 SHQQLMPSHANGYIHK-----GTDGVCYGEVSSDVDPDANGMLGSRVGSFFAGH----------- 877

  Fly   669 INSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEMATSVFCSEGQESDLFDSN--YPDLLDIAKY 731
             ||.|              ::.|.....|.|.......|.|     ||.:|:.  |....:...|
Zfish   878 -NSFH--------------RSEPREGQSNIPNGGAGALVIC-----SDCYDNANIYSRTREYCPY 922

  Fly   732 A--------VAQAQQEG---RGQGYAQATTT-------PNGG--LCTLPRKLKTS--------GK 768
            |        |||..::|   |.|....:...       .|..  |.....:|..|        |:
Zfish   923 AYLTEDDPLVAQISRDGPQERDQHSENSDAVLESFINQQNASVFLSNHEPRLSASQHYSTDIPGR 987

  Fly   769 YFRNSSDSQSPLLADNS 785
            .|.::.|:.|.:||..|
Zfish   988 SFWDAEDTHSSILAQGS 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	55/227 (24%)
		leucine-rich repeat	112..137	CDD:275380	7/22 (32%)
		LRR_8	137..196	CDD:290566	22/82 (27%)
		leucine-rich repeat	138..161	CDD:275380	9/46 (20%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	23/60 (38%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	10/23 (43%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	11/71 (15%)
		IG_like	328..428	CDD:214653	29/184 (16%)
		Ig	335..425	CDD:143165	25/174 (14%)
lrig2	XP_021332954.1	NEL	<7..>191	CDD:330839	13/39 (33%)
		leucine-rich repeat	38..57	CDD:275380
		leucine-rich repeat	58..81	CDD:275380
		leucine-rich repeat	83..104	CDD:275380
		PLN00113	<128..>403	CDD:331614	56/252 (22%)
		leucine-rich repeat	128..151	CDD:275380
		leucine-rich repeat	152..174	CDD:275380	6/19 (32%)
		leucine-rich repeat	175..198	CDD:275380	6/22 (27%)
		leucine-rich repeat	199..246	CDD:275380	11/46 (24%)
		leucine-rich repeat	247..270	CDD:275380	8/22 (36%)
		LRR_8	270..329	CDD:316378	20/59 (34%)
		leucine-rich repeat	271..294	CDD:275380	10/23 (43%)
		leucine-rich repeat	295..318	CDD:275380	8/22 (36%)
		leucine-rich repeat	319..345	CDD:275380	0/25 (0%)
		leucine-rich repeat	346..369	CDD:275380	0/22 (0%)
		leucine-rich repeat	370..391	CDD:275380	4/20 (20%)
		LRRCT	403..451	CDD:214507	10/47 (21%)
		Ig	459..553	CDD:325142	11/93 (12%)
		Ig_1	574..648	CDD:143240	19/77 (25%)
		I-set	651..738	CDD:254352	17/103 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574208
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930