DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrrc4.2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001093494.1	Gene:	lrrc4.2 / 566572	ZFINID:	ZDB-GENE-030131-7997	Length:	644	Species:	Danio rerio

Alignment Length:	696	Identity:	173/696 - (24%)
Similarity:	246/696 - (35%)	Gaps:	236/696 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 LLW-----------LLCC-----------CSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHI 104
            |||           |||.           .:..|||  .||:||.|...|.|  |:|...:|..:
Zfish     3 LLWQVTVHRAWNAALLCAVYLMVRSWSVSAAPSGQL--TCPSVCFCSNVSNK--VVCTRRSLVRV 63

  Fly   105 PQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQ 169
            |..:.|.|:.|:|..|.|:.|...:|  ..|.:|:.:.|.|..:|.||..||..|.:|..|:|..
Zfish    64 PPGIPATTRHLNLMENSIETIEAGTF--QHLRHLEVLQLGRNSIRQIEVGAFSGLNSLNTLELFD 126

  Fly   170 NLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCR-LSHIAVRAFAGLES 233
            |.|:.|||.|..::|:||||.|..|||..:|..||..||.|::|:|.:.| |.:|:..||.||.:
Zfish   127 NRLTVIPSGAFEYLSKLRELWLRSNPIESIPSYAFNRVPSLMRLDLGELRKLEYISEGAFEGLHN 191

  Fly   234 ---------------------SLEWLKLDGNRLSEVRSGTITSLASL------------------ 259
                                 .||.|::..|...|::.|:...|.||
Zfish   192 LKYLNLGMCNLREMPVLTPLVGLEELEMSENYFPELKPGSFRGLKSLKKLWIMNSRITTIERNAF 256

  Fly   260 ------------HG------------------LELARNTWNCSCSLRPLRAWMLQQNIP--SGIP 292
                        |.                  |.|..|.|.|.|.:..| ||.|::.||  |...
Zfish   257 DDVTALVELNLAHNNLSSLPHDLFAPLSYLVELHLHHNPWRCDCDVVWL-AWWLREYIPTNSTCC 320

  Fly   293 PTCESPPRLSGRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNR 356
            ..|.:|..|.||...::|...|.| .|.|:......:....|...:.|  ...|..:|:|||.|.
Zfish   321 GRCHTPAYLRGRYLVEVDQSTFQCSAPFILDAPRDLNISAERVAELKC--RTAPMSSVRWLLPNG 383

  Fly   357 LIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVE 421
            .:  |:.|     .:.||.:....|        ..|.||  :|.|   |.|:|||...|.||...
Zfish   384 TV--LTHG-----SNHPRISVLNDG--------TLNFSN--VLPA---DTGVYTCMVTNMAGNSN 428

  Fly   422 ASVTLAV---------------------------------------------------------- 428
            ||..|.|
Zfish   429 ASAYLNVTAAELNTSNLSYFTTVTVEEVEPTSQEVIKPKTVTASPSVFQPVFISTPTVLLQTPRQ 493

  Fly   429 --------SRRPP----EAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPV 481
                    :.|||    |.....:||:...||..||      ||:.|.:..:.||.....|.  |
Zfish   494 VSVPTVRGTTRPPASLDEVMKTTKIIIGCFVAVTLL------AAVMLIAFYKLRKRHQQRST--V 550

  Fly   482 RRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVN 546
            ..|.:.|.|:|      |.....:..|.|..|        |.|.:..:   |.|:::....:...
Zfish   551 AASGTMEAIQM------DENVSTTHAGTSIPG--------ECGMMLPS---LRDHNSTYKPSSYR 598

  Fly   547 P--SAGSAQRRNGDYLH---------------VSTHCDDEEEDQQL 575
            |  ||..|:...|:.||               :.||..::.::.|:
Zfish   599 PAHSAPWAENNIGNSLHRSRPMTISTIPEPYLIKTHTKEKVQETQI 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	63/226 (28%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	25/58 (43%)
		leucine-rich repeat	138..161	CDD:275380	9/22 (41%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	28/82 (34%)
		leucine-rich repeat	186..209	CDD:275380	12/22 (55%)
		leucine-rich repeat	210..234	CDD:275380	10/45 (22%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		LRRCT	267..316	CDD:214507	18/50 (36%)
		IG_like	328..428	CDD:214653	29/99 (29%)
		Ig	335..425	CDD:143165	27/89 (30%)
lrrc4.2	NP_001093494.1	leucine-rich repeat	71..94	CDD:275380	8/24 (33%)
		LRR_8	72..129	CDD:290566	20/58 (34%)
		LRR_RI	74..>276	CDD:238064	59/203 (29%)
		leucine-rich repeat	95..118	CDD:275380	9/22 (41%)
		leucine-rich repeat	119..142	CDD:275380	9/22 (41%)
		LRR_8	141..202	CDD:290566	24/60 (40%)
		leucine-rich repeat	143..166	CDD:275380	12/22 (55%)
		leucine-rich repeat	167..191	CDD:275380	10/23 (43%)
		leucine-rich repeat	192..213	CDD:275380	0/20 (0%)
		LRR_8	213..272	CDD:290566	10/58 (17%)
		leucine-rich repeat	214..237	CDD:275380	7/22 (32%)
		leucine-rich repeat	238..261	CDD:275380	1/22 (5%)
		leucine-rich repeat	262..283	CDD:275380	1/20 (5%)
		LRRCT	294..345	CDD:214507	18/51 (35%)
		IG_like	353..435	CDD:214653	29/103 (28%)
		Ig	365..435	CDD:299845	28/91 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12164
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104601
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810