DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and lingo1a

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_005174327.1	Gene:	lingo1a / 564943	ZFINID:	ZDB-GENE-080327-16	Length:	615	Species:	Danio rerio

Alignment Length:	614	Identity:	135/614 - (21%)
Similarity:	196/614 - (31%)	Gaps:	230/614 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSF------------- 130
            ||:.|||..:  :.||||....|..:|:.:.:.|:|||||.|.|:.|..|.|
Zfish    35 CPSRCECNVQ--ERSVLCHRKKLMSVPEGIPSETRLLDLSKNRIKTINPDEFSAFPQLEELELNE 97

  Fly   131 ---------ATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNL--------------- 171
                     |...|..||.:.|....|:||:...|..|.||.:||:|:|.
Zfish    98 NTISAIEPGAFNNLYGLQTLGLRSNKLKLIQLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNL 162

  Fly   172 ----------------------------------------------------------------- 171

Zfish   163 RSLEVGDNDLVFISHRAFHGLSSLEQLTLEKCNLTSVPTEAFTHLHSLVTLRLRNLNINSIRDYS 227

  Fly   172 ----------------------------------------LSAIPSLALYHVSELRELRLSGNPI 196
                                                    |::||.|||.|:..||.|.:|.|||
Zfish   228 FKRLYRLKVLEIANWPYLDTMTTNCLYGLNLTSLTITNANLTSIPYLALRHLVYLRFLNMSYNPI 292

  Fly   197 LRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHG 261
            ..:..:....:.:|.:|.|...|||.|...:|.|| :.|:.|.:..|.|:.:......|:.:|..
Zfish   293 QMIEGNRLHDLLRLQELYLVGGRLSVIEPYSFRGL-NYLKVLNVSSNFLTTLEESVFHSVGNLET 356

  Fly   262 LELARNTWNCSCSLRPL--RAWMLQQNIPSGIPPTCESPPRLSGRAW----DKLDVDDFAC---- 316
            |.|..|...|.|.|..:  |.|.|..|...   |||.||..:.|:.:    |.|..:.|.|
Zfish   357 LALHDNPLACDCRLLWVFRRRWRLNFNRQQ---PTCSSPEFVQGKEFKDFPDILQPNYFTCRKSR 418

  Fly   317 ----VPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAA 377
                .||....|      ||..:...|..:|.|.|.:.||...:....:.
Zfish   419 IRDRKPQQKFVD------EGTTVHFVCQADGDPTPVIMWLSPQKQFITMK--------------- 462

  Fly   378 ATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEA-----------------SVT 425
             |.||.|...:     ..|.:..|.:||.|.|.|.|.|..|...|                 :.|
Zfish   463 -TIGRLTVFPD-----GTLEVRYAQIQDNGTYGCIASNAGGNDTALAHLHVHSYSPDWPNQPNKT 521

  Fly   426 LA-VSRRPPE-----------APWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSV 478
            || :|.:|.:           .|:.::.:::...     :|..||..:.|..|.   .|.||:.
Zfish   522 LAFISNQPNDNSINETRATVPFPFDIKTLIIATT-----MGFISFLGVVLFCLV---LLFLWSR- 577

  Fly   479 PPVRRSESYEKIEMTARTRPDLGGGASCG 507
               .:..|...||:....|....|.:|.|
Zfish   578 ---GKGNSKHNIEIEYVPRKSDAGMSSSG 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	59/298 (20%)
		leucine-rich repeat	112..137	CDD:275380	13/46 (28%)
		LRR_8	137..196	CDD:290566	26/178 (15%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	12/142 (8%)
		LRR_8	184..245	CDD:290566	20/60 (33%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	10/23 (43%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	17/54 (31%)
		IG_like	328..428	CDD:214653	26/117 (22%)
		Ig	335..425	CDD:143165	21/106 (20%)
lingo1a	XP_005174327.1	LRRNT	34..68	CDD:214470	12/34 (35%)
		LRR_RI	<55..231	CDD:238064	29/175 (17%)
		leucine-rich repeat	66..89	CDD:275380	11/22 (50%)
		LRR_8	88..148	CDD:290566	16/59 (27%)
		leucine-rich repeat	90..113	CDD:275380	2/22 (9%)
		leucine-rich repeat	114..137	CDD:275380	8/22 (36%)
		LRR_8	136..196	CDD:290566	6/59 (10%)
		leucine-rich repeat	138..185	CDD:275380	5/46 (11%)
		LRR_8	184..241	CDD:290566	0/56 (0%)
		leucine-rich repeat	186..209	CDD:275380	0/22 (0%)
		leucine-rich repeat	210..257	CDD:275380	0/46 (0%)
		leucine-rich repeat	234..256	CDD:275380	0/21 (0%)
		LRR_8	257..316	CDD:290566	17/58 (29%)
		leucine-rich repeat	258..281	CDD:275380	7/22 (32%)
		leucine-rich repeat	282..305	CDD:275380	7/22 (32%)
		LRR_8	305..364	CDD:290566	19/59 (32%)
		leucine-rich repeat	306..329	CDD:275380	10/23 (43%)
		leucine-rich repeat	330..350	CDD:275380	4/19 (21%)
		TPKR_C2	362..>398	CDD:301599	13/38 (34%)
		I-set	421..507	CDD:254352	26/112 (23%)
		Ig	432..507	CDD:299845	22/95 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910