DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrig3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001103817.1	Gene:	lrig3 / 564554	ZFINID:	ZDB-GENE-130530-866	Length:	1070	Species:	Danio rerio

Alignment Length:	943	Identity:	185/943 - (19%)
Similarity:	280/943 - (29%)	Gaps:	359/943 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 LDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLL 172
            |.:...:|.|:.|.:..||...|:   |.:||.:.|:|..||.:|...|:.|..|..|.:.:|.:
Zfish   179 LSSSLLVLKLNKNRLNSIPAKIFS---LPHLQHLELSRNRLRRVEGLTFQGLHGLRSLKMQRNGI 240

  Fly   173 SAIPSLA------------------------LYHVSELRELRLSGNPILRVPDDAFGHVPQLVKL 213
            |.:...|                        ||.:..|::|.||.|.|.|:..||:....:|.:|
Zfish   241 SRLMDGAFWGLNNMEVLQLEFNNLTEVSKGWLYGLLTLQQLHLSHNSISRIKPDAWEFCQKLAEL 305

  Fly   214 ELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARN--TWN------ 270
            :||..:||.:...:|.|| |.||.|.:..||:|.:..|....|.:|..|:|..|  :|.
Zfish   306 DLSWNQLSRLEEGSFVGL-SVLEQLHIGNNRISFIADGAFRGLTNLQTLDLKFNEISWTIEDMNG 369

  Fly   271 ----------------------------------------------------------------- 270

Zfish   370 PFSALDNLRKLFLQGNRIRSVTRKSFTGLEMLEQLDLSNNAIMSLQANAFSQMKKLSELHLNTSS 434

  Fly   271 --CSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFAC----VPQIVATDTTAHG 329
              |.|.|:....|:.:|...:.:..:|..|..|.||:...:..|:|.|    .|||.....|...
Zfish   435 LLCDCQLKWFSLWVAEQAFLALLNASCAHPHLLKGRSVFSIAQDEFVCDDFPKPQITVQPETQSA 499

  Fly   330 VEGRNITMSCYVEGVPQPAV--KWLLKNRLIA----------NLSAGGDGDSDSEPRTAA----- 377
            ::|.|:|..|.........:  .|...|.|::          ..:||..|:......|..
Zfish   500 IKGNNVTFVCSAASSSDSPMTFAWKKDNELLSEPEIQNQAHVRAAAGETGELTEYTTTLQLRQVE 564

  Fly   378 -ATQGRKTYV----------------VNML----RNASNLTI---LTADM--------------- 403
             .::||...|                ||||    :...:|||   .||.:
Zfish   565 FTSEGRYQCVISNHFGSSYSNKAKLTVNMLPFFTKTPMDLTIRAGATARLECAASGHPSPQIAWQ 629

  Fly   404 -------------------------------QDAGIYTCAAENKAGKVEASVTLAVSRRPP-EAP 436
                                           :|.|:|:|.|:|.||.:.|:.||.|...|. ..|
Zfish   630 KDGGTDFPAARERRMHVMPRDDVFFIVDVKTEDIGVYSCTAQNTAGAISANATLTVLETPSFLRP 694

  Fly   437 WGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLG 501
            ...|.:..|..|.|..:.|.|                     ||.|.:.:.:...:.|..|....
Zfish   695 LLDRAVAKGETAVLQCIAGGS---------------------PPPRLNWTKDDSPLQATERHFFA 738

  Fly   502 GG----------------ASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAG 550
            .|                .:|...:..|.       |:|.||.:..|..:.|.|.|......:||
Zfish   739 AGNQLLIIVDAAEGDAGTYTCEMSNPLGT-------ERGNLRLSVLPNPNCDQGPAGGGAVGAAG 796

  Fly   551 S------------------------------------AQRRNGDYLHVSTHCDDEEEDQQLHHHP 579
            |                                    .:|||.|       |.....|:.  :.|
Zfish   797 SGRGPEDDGWTTVGIVIIAVVCCVVGTSLVWVVIIYHTRRRNED-------CSVTNTDET--NLP 852

  Fly   580 QQQP---ASQHHPHPNQQQHQ--QRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASS 639
            ...|   :||......|..:.  ...||....:|:|......|  ..|::....:|.|    :.:
Zfish   853 ADIPSYLSSQGTLAERQDGYMLPSESGSSHQFISSSIGGFYMP--PKDMNSLCQLDTG----SEA 911

  Fly   640 SISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEMA 704
            .:.:.:|..  |..|.|                   ||.|.        .||.|||.....|...
Zfish   912 DLEAAIDPL--LCHYQG-------------------PVGSL--------LTPGAHYSAELPDTYT 947

  Fly   705 TSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNG----------GLCTL 759
            ..|     .|..|...:|....|.  |..:.:...      ......|:.          ..|.|
Zfish   948 VCV-----SEPRLLSDSYSRKRDF--YTCSSSLDP------CDHMMLPHDIPSCVDDCETDQCVL 999

  Fly   760 PRKLKTSGKY--------FRNSSDSQSPLLADN 784
            ||    ||.|        :|.:.|..:.:|.:|
Zfish  1000 PR----SGSYMGTFGKAAWRPTQDHSAVILHEN 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	53/180 (29%)
		leucine-rich repeat	112..137	CDD:275380	7/24 (29%)
		LRR_8	137..196	CDD:290566	21/82 (26%)
		leucine-rich repeat	138..161	CDD:275380	9/22 (41%)
		leucine-rich repeat	162..185	CDD:275380	7/46 (15%)
		LRR_8	184..245	CDD:290566	23/60 (38%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	14/123 (11%)
		IG_like	328..428	CDD:214653	34/186 (18%)
		Ig	335..425	CDD:143165	30/176 (17%)
lrig3	NP_001103817.1	LRR_RI	<62..330	CDD:238064	45/154 (29%)
		LRR_8	63..121	CDD:290566
		leucine-rich repeat	64..87	CDD:275378
		leucine-rich repeat	88..110	CDD:275378
		LRR_8	110..168	CDD:290566
		leucine-rich repeat	111..134	CDD:275380
		leucine-rich repeat	135..156	CDD:275380
		leucine-rich repeat	158..205	CDD:275380	8/28 (29%)
		LRR_8	204..264	CDD:290566	14/59 (24%)
		leucine-rich repeat	206..229	CDD:275380	9/22 (41%)
		leucine-rich repeat	230..253	CDD:275380	5/22 (23%)
		LRR_RI	251..>435	CDD:238064	34/184 (18%)
		LRR_8	253..312	CDD:290566	15/58 (26%)
		leucine-rich repeat	254..277	CDD:275380	2/22 (9%)
		leucine-rich repeat	278..301	CDD:275380	9/22 (41%)
		LRR_8	301..360	CDD:290566	22/59 (37%)
		leucine-rich repeat	302..325	CDD:275380	9/23 (39%)
		leucine-rich repeat	326..349	CDD:275380	8/22 (36%)
		LRR_8	376..431	CDD:290566	0/54 (0%)
		leucine-rich repeat	377..400	CDD:275380	0/22 (0%)
		leucine-rich repeat	401..422	CDD:275380	0/20 (0%)
		TPKR_C2	435..483	CDD:301599	12/47 (26%)
		I-set	488..591	CDD:254352	18/102 (18%)
		Ig	505..581	CDD:143165	12/75 (16%)
		I-set	595..685	CDD:254352	16/89 (18%)
		Ig_1	612..686	CDD:143240	12/73 (16%)
		I-set	689..776	CDD:254352	20/114 (18%)
		IGc2	703..766	CDD:197706	12/83 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574239
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840