Protein Alignment kek3 and lrig3

DIOPT Version :10

• Sequence 1: NP_523575.1
• Gene: kek3 / 34912
• FlyBaseID: FBgn0028370
• Length: 1021
• Species: Drosophila melanogaster
• Sequence 2: NP_001103817.1
• Gene: lrig3 / 564554
• ZFINID: ZDB-GENE-130530-866
• Length: 1070
• Species: Danio rerio
• Alignment Length: 943
• Identity: 185/943 - (19%)
• Similarity: 280/943 - (29%)
• Gaps: 359/943 - (38%)

  Fly   108 LDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLL 172
            |.:...:|.|:.|.:..||...|:   |.:||.:.|:|..||.:|...|:.|..|..|.:.:|.:
Zfish   179 LSSSLLVLKLNKNRLNSIPAKIFS---LPHLQHLELSRNRLRRVEGLTFQGLHGLRSLKMQRNGI 240

  Fly   173 SAIPSLA------------------------LYHVSELRELRLSGNPILRVPDDAFGHVPQLVKL 213
            |.:...|                        ||.:..|::|.||.|.|.|:..||:....:|.:|
Zfish   241 SRLMDGAFWGLNNMEVLQLEFNNLTEVSKGWLYGLLTLQQLHLSHNSISRIKPDAWEFCQKLAEL 305

  Fly   214 ELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARN--TWN------ 270
            :||..:||.:...:|.|| |.||.|.:..||:|.:..|....|.:|..|:|..|  :|.
Zfish   306 DLSWNQLSRLEEGSFVGL-SVLEQLHIGNNRISFIADGAFRGLTNLQTLDLKFNEISWTIEDMNG 369

  Fly   271 ----------------------------------------------------------------- 270
                                                                             
Zfish   370 PFSALDNLRKLFLQGNRIRSVTRKSFTGLEMLEQLDLSNNAIMSLQANAFSQMKKLSELHLNTSS 434

  Fly   271 --CSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFAC----VPQIVATDTTAHG 329
              |.|.|:....|:.:|...:.:..:|..|..|.||:...:..|:|.|    .|||.....|...
Zfish   435 LLCDCQLKWFSLWVAEQAFLALLNASCAHPHLLKGRSVFSIAQDEFVCDDFPKPQITVQPETQSA 499

  Fly   330 VEGRNITMSCYVEGVPQPAV--KWLLKNRLIA----------NLSAGGDGDSDSEPRTAA----- 377
            ::|.|:|..|.........:  .|...|.|::          ..:||..|:......|..
Zfish   500 IKGNNVTFVCSAASSSDSPMTFAWKKDNELLSEPEIQNQAHVRAAAGETGELTEYTTTLQLRQVE 564

  Fly   378 -ATQGRKTYV----------------VNML----RNASNLTI---LTADM--------------- 403
             .::||...|                ||||    :...:|||   .||.:
Zfish   565 FTSEGRYQCVISNHFGSSYSNKAKLTVNMLPFFTKTPMDLTIRAGATARLECAASGHPSPQIAWQ 629

  Fly   404 -------------------------------QDAGIYTCAAENKAGKVEASVTLAVSRRPP-EAP 436
                                           :|.|:|:|.|:|.||.:.|:.||.|...|. ..|
Zfish   630 KDGGTDFPAARERRMHVMPRDDVFFIVDVKTEDIGVYSCTAQNTAGAISANATLTVLETPSFLRP 694

  Fly   437 WGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLG 501
            ...|.:..|..|.|..:.|.|                     ||.|.:.:.:...:.|..|....
Zfish   695 LLDRAVAKGETAVLQCIAGGS---------------------PPPRLNWTKDDSPLQATERHFFA 738

  Fly   502 GG----------------ASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAG 550
            .|                .:|...:..|.       |:|.||.:..|..:.|.|.|......:||
Zfish   739 AGNQLLIIVDAAEGDAGTYTCEMSNPLGT-------ERGNLRLSVLPNPNCDQGPAGGGAVGAAG 796

  Fly   551 S------------------------------------AQRRNGDYLHVSTHCDDEEEDQQLHHHP 579
            |                                    .:|||.|       |.....|:.  :.|
Zfish   797 SGRGPEDDGWTTVGIVIIAVVCCVVGTSLVWVVIIYHTRRRNED-------CSVTNTDET--NLP 852

  Fly   580 QQQP---ASQHHPHPNQQQHQ--QRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSASS 639
            ...|   :||......|..:.  ...||....:|:|......|  ..|::....:|.|    :.:
Zfish   853 ADIPSYLSSQGTLAERQDGYMLPSESGSSHQFISSSIGGFYMP--PKDMNSLCQLDTG----SEA 911

  Fly   640 SISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEMA 704
            .:.:.:|..  |..|.|                   ||.|.        .||.|||.....|...
Zfish   912 DLEAAIDPL--LCHYQG-------------------PVGSL--------LTPGAHYSAELPDTYT 947

  Fly   705 TSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPNG----------GLCTL 759
            ..|     .|..|...:|....|.  |..:.:...      ......|:.          ..|.|
Zfish   948 VCV-----SEPRLLSDSYSRKRDF--YTCSSSLDP------CDHMMLPHDIPSCVDDCETDQCVL 999

  Fly   760 PRKLKTSGKY--------FRNSSDSQSPLLADN 784
            ||    ||.|        :|.:.|..:.:|.:|
Zfish  1000 PR----SGSYMGTFGKAAWRPTQDHSAVILHEN 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_523575.1	LRR	<98..>267	CDD:443914	54/182 (30%)
		leucine-rich repeat	112..137	CDD:275380	7/24 (29%)
		leucine-rich repeat	138..161	CDD:275380	9/22 (41%)
		leucine-rich repeat	162..185	CDD:275380	7/46 (15%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	9/23 (39%)
		leucine-rich repeat	235..258	CDD:275380	8/22 (36%)
		LRRCT	267..316	CDD:214507	14/123 (11%)
		Ig	331..428	CDD:472250	34/183 (19%)
		Ig strand B	335..339	CDD:409562	1/3 (33%)
		Ig strand C	348..352	CDD:409562	0/5 (0%)
		Ig strand E	394..398	CDD:409562	1/3 (33%)
		Ig strand F	408..413	CDD:409562	2/4 (50%)
		Ig strand G	421..424	CDD:409562	1/2 (50%)
lrig3	NP_001103817.1	leucine-rich repeat	64..87	CDD:275378
		LRR	88..436	CDD:443914	56/260 (22%)
		leucine-rich repeat	88..110	CDD:275378
		leucine-rich repeat	111..134	CDD:275380
		leucine-rich repeat	135..156	CDD:275380
		leucine-rich repeat	158..205	CDD:275380	8/28 (29%)
		leucine-rich repeat	206..229	CDD:275380	9/22 (41%)
		leucine-rich repeat	230..253	CDD:275380	5/22 (23%)
		leucine-rich repeat	254..277	CDD:275380	2/22 (9%)
		leucine-rich repeat	278..301	CDD:275380	9/22 (41%)
		leucine-rich repeat	302..325	CDD:275380	9/23 (39%)
		leucine-rich repeat	326..349	CDD:275380	8/22 (36%)
		leucine-rich repeat	377..400	CDD:275380	0/22 (0%)
		leucine-rich repeat	401..422	CDD:275380	0/20 (0%)
		PCC	405..>483	CDD:188093	12/77 (16%)
		Ig_3	487..577	CDD:464046	18/89 (20%)
		IgI_LRIG1-like	597..686	CDD:409420	16/88 (18%)
		Ig strand A'	603..607	CDD:409420	2/3 (67%)
		Ig strand B	610..619	CDD:409420	2/8 (25%)
		Ig strand C	625..630	CDD:409420	0/4 (0%)
		Ig strand C'	633..635	CDD:409420	0/1 (0%)
		Ig strand D	643..647	CDD:409420	0/3 (0%)
		Ig strand E	651..658	CDD:409420	0/6 (0%)
		Ig strand F	664..672	CDD:409420	4/7 (57%)
		Ig strand G	675..686	CDD:409420	4/10 (40%)
		I-set	689..776	CDD:400151	20/114 (18%)
		Ig strand B	706..710	CDD:409353	2/3 (67%)
		Ig strand C	719..723	CDD:409353	1/3 (33%)
		Ig strand E	742..746	CDD:409353	0/3 (0%)
		Ig strand F	756..761	CDD:409353	1/4 (25%)
		Ig strand G	769..772	CDD:409353	1/2 (50%)