DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrrc4cb

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_005166545.1	Gene:	lrrc4cb / 564462	ZFINID:	ZDB-GENE-080327-5	Length:	631	Species:	Danio rerio

Alignment Length:	718	Identity:	173/718 - (24%)
Similarity:	267/718 - (37%)	Gaps:	203/718 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 QRRTLATKVRRKGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAE-CPAVCECKWKSGK 91
            ||:.|      :|||.:.....|        |.|||..|......|.:||: ||:||.|..:..|
Zfish    10 QRQML------RGPRWKGAWFDP--------LFLLLLALQLLVVAGLVRAQTCPSVCSCSNQFSK 60

  Fly    92 ESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAF 156
              |:|....|..:|..:...|:.|:|..|:||:|..|||  ..|.:|:.:.|:|.|:|.||..||
Zfish    61 --VICTRRGLKDVPDGVSTNTRYLNLQDNQIQVIKVDSF--KHLRHLEILQLSRNHIRNIEIGAF 121

  Fly   157 RKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDC-RL 220
            ..|.:|..|:|..|.|:.||:.|..::|:|:||.|..|||..:|.|||..:|.|.:|:|.:. ||
Zfish   122 NGLTSLNTLELFDNRLTTIPNGAFEYLSKLKELWLRNNPIESIPSDAFSRLPSLRRLDLGELKRL 186

  Fly   221 SHIAVRAFAGLES---------------------SLEWLKLDGNRLSEVRSGTITSLA------- 257
            |:|:..||.||.:                     .|:.|::.||:|:.::..:...|.
Zfish   187 SYISSGAFQGLSNLRYLNLGMCNLKEVPNIQPLIRLDELEMSGNQLTVIQPSSFKGLVHLQKLWM 251

  Fly   258 -----------------SLHGLELARNT------------------------WNCSCSLRPLRAW 281
                             ||..|.||.|.                        |||:|.:..| :|
Zfish   252 MHAQVQTIERNSFDDLHSLRELNLAHNNLTFLPHDLYTPLHHLQRVHLHHNPWNCNCDILWL-SW 315

  Fly   282 MLQQNIPSGIP--PTCESPPRLSGRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNITMSCYVEG 343
            .|::.:|:...  ..|.|||.|.||...:||...|.| .|.|:......:..||....:.|....
Zfish   316 WLRETVPTNTSCCARCNSPPSLKGRYIGELDQSYFQCYAPVIIEPPVDLNLTEGMAAELKCRTNS 380

  Fly   344 VPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGI 408
            |  .:|.||                   .|..:..|.|.....:| ::|...|......:||.|.
Zfish   381 V--TSVSWL-------------------TPNGSIITHGTLKMRIN-VQNDGTLNFTNVTLQDTGT 423

  Fly   409 YTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLR 473
            |||...|..|...||..|.|:.                      |..|.|:.....::
Zfish   424 YTCYVSNMLGNTSASAILNVTS----------------------VDNSGFSYFTTVTV------- 459

  Fly   474 LWNSVPPVRRSESYE-KIEMTART--RPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLND 535
                       |:.| .|:..:||  :|..|..:|   .:..|..:   |.|:.|.    .|:.:
Zfish   460 -----------ETIETPIDGESRTPVQPSFGWASS---STTRGTPI---ATERAYT----IPVTE 503

  Fly   536 NDAGQAAAIVNPSAGSAQRRNGDYLHVST----------------HCDDEE------EDQQLHHH 578
            .|...|...:.....:.:...|.::.::.                |..|.:      |...:|..
Zfish   504 IDIDGALNGLEEVMKTTKIIIGCFVAITLMAAVMLIIFYKMRKQHHQQDHDGPSRSMEIISVHED 568

  Fly   579 PQQQPASQHH------PHPNQQQHQQRKGSQGHVVSASGANNSAPLEETDLHIPRLIDIGGTDSA 637
            ..:.||.:.|      .|.:...:...|.:..||.:.|..::|       :|.|.||.....|:.
Zfish   569 LTRVPAMESHLTLPPLEHDHYNHYNSYKTAYNHVSALSSLHSS-------VHEPLLIQASSKDNV 626

  Fly   638 SSS 640
            ..:
Zfish   627 QET 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	64/202 (32%)
		leucine-rich repeat	112..137	CDD:275380	11/24 (46%)
		LRR_8	137..196	CDD:290566	24/58 (41%)
		leucine-rich repeat	138..161	CDD:275380	10/22 (45%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	28/82 (34%)
		leucine-rich repeat	186..209	CDD:275380	11/22 (50%)
		leucine-rich repeat	210..234	CDD:275380	11/45 (24%)
		leucine-rich repeat	235..258	CDD:275380	6/46 (13%)
		LRRCT	267..316	CDD:214507	19/74 (26%)
		IG_like	328..428	CDD:214653	24/99 (24%)
		Ig	335..425	CDD:143165	21/89 (24%)
lrrc4cb	XP_005166545.1	LRRNT	48..81	CDD:214470	11/34 (32%)
		LRR_8	77..137	CDD:290566	25/61 (41%)
		leucine-rich repeat	79..102	CDD:275380	11/24 (46%)
		LRR_RI	82..>281	CDD:238064	64/200 (32%)
		leucine-rich repeat	103..126	CDD:275380	10/22 (45%)
		LRR_8	125..180	CDD:290566	23/54 (43%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275380	11/22 (50%)
		leucine-rich repeat	175..199	CDD:275380	11/23 (48%)
		leucine-rich repeat	200..221	CDD:275380	0/20 (0%)
		LRR_8	221..280	CDD:290566	12/58 (21%)
		leucine-rich repeat	222..245	CDD:275380	6/22 (27%)
		leucine-rich repeat	246..269	CDD:275380	0/22 (0%)
		leucine-rich repeat	270..291	CDD:275380	5/20 (25%)
		LRRCT	302..352	CDD:214507	18/50 (36%)
		I-set	355..443	CDD:254352	26/109 (24%)
		Ig	372..439	CDD:143165	20/88 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12164
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	1	0.900	-	-		OOG6_104601
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5308
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.840