DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lingo2b

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001139054.1	Gene:	lingo2b / 564052	ZFINID:	ZDB-GENE-080723-57	Length:	607	Species:	Danio rerio

Alignment Length:	530	Identity:	128/530 - (24%)
Similarity:	182/530 - (34%)	Gaps:	203/530 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LPLHLHLLLWLLCCCSQLGQLRAE-CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLS 118
            |||||.             |..|. |||.|||...:  .||.|....|..:|:.:...|:.||||
Zfish    15 LPLHLF-------------QCPAHACPARCECSVPT--RSVSCHRRRLAQVPEGIPIETRSLDLS 64

  Fly   119 GNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHV 183
            .|.::::...:|::  ||.|:::.|:...|..:|.::||....|..|.|..|.|:.:|..||..:
Zfish    65 KNRLRIVTPQNFSS--LLLLEELDLSNNLLSSVEPNSFRAQPRLRSLRLRSNQLTLLPRGALAGL 127

  Fly   184 SELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEV 248
            |||..|.:|.|.::.:.|..|....:|..|||||..|..||.|||:|| :||..|.|....||.|
Zfish   128 SELTLLDVSQNRLVILLDYGFEEQRRLRVLELSDNELVFIAPRAFSGL-ASLRSLTLQRCNLSTV 191

  Fly   249 RSGTITSLASLHGL-----------ELARNTWN-------------------------------- 270
            .:   .:||.||||           ||..:|:.
Zfish   192 PT---HALAHLHGLTSLRLRDLGIAELQAHTFKGLPRLKHLEVDRWPLLEGFPTSALQGLNLSTL 253

  Fly   271 ----------------------------------------------------------------- 270

Zfish   254 SITHTNLTSVPVVTNLLYLTHLNLSYSRIRVLPAGWLRGMDRLEVLRVRQANLLSVEPQAFQGAS 318

  Fly   271 -------------------------------------CSCSLRPLRAWMLQQNIP---SGIPPTC 295
                                                 |.|.||    |:|::..|   ..:.|.|
Zfish   319 SLRILDLCYNRLATLERSVFPVTEALQTLLIGQNPLVCDCRLR----WLLERTPPLLYGDVQPEC 379

  Fly   296 ESPPRLSGRAWDKL---DVDDFA-CV-PQIVA-TDTTAHGVEGRNITMSCYVEGVPQPAVKWLLK 354
            .:|..|:|:....|   .:..:. |. |:::: ....|...||:...:.|..:|.|.|:|.||..
Zfish   380 SAPAPLAGKPLRDLVEAQISRYVICTKPRVISMASYPAQAEEGQRAWLYCSADGAPPPSVSWLTP 444

  Fly   355 -NRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAG 418
             .|.|...|.|         |....|.|             :|....|:.||:|:|.|.|.|.||
Zfish   445 LRRHITTKSTG---------RVVVHTNG-------------SLEFRMAEPQDSGMYVCVASNPAG 487

  Fly   419 KVEASVTLAV 428
            ....||||||
Zfish   488 NATLSVTLAV 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	60/167 (36%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	20/58 (34%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	26/60 (43%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	14/23 (61%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		LRRCT	267..316	CDD:214507	14/189 (7%)
		IG_like	328..428	CDD:214653	31/100 (31%)
		Ig	335..425	CDD:143165	26/90 (29%)
lingo2b	NP_001139054.1	LRRNT	26..58	CDD:214470	11/33 (33%)
		leucine-rich repeat	37..60	CDD:275380	6/24 (25%)
		LRR_8	59..116	CDD:290566	18/58 (31%)
		leucine-rich repeat	61..81	CDD:275380	7/21 (33%)
		LRR_RI	<103..214	CDD:238064	43/114 (38%)
		LRR_8	104..188	CDD:290566	34/84 (40%)
		leucine-rich repeat	106..129	CDD:275380	8/22 (36%)
		leucine-rich repeat	130..153	CDD:275380	6/22 (27%)
		leucine-rich repeat	154..177	CDD:275380	14/23 (61%)
		leucine-rich repeat	178..201	CDD:275380	9/25 (36%)
		LRR_8	201..260	CDD:290566	5/58 (9%)
		leucine-rich repeat	202..225	CDD:275380	4/22 (18%)
		leucine-rich repeat	226..271	CDD:275380	0/44 (0%)
		LRR_8	272..330	CDD:290566	0/57 (0%)
		leucine-rich repeat	272..295	CDD:275380	0/22 (0%)
		leucine-rich repeat	296..319	CDD:275380	0/22 (0%)
		leucine-rich repeat	320..338	CDD:275380	0/17 (0%)
		leucine-rich repeat	344..356	CDD:275378	0/11 (0%)
		LRRCT	352..394	CDD:214507	12/45 (27%)
		IG_like	419..497	CDD:214653	31/99 (31%)
		Ig	422..497	CDD:299845	30/96 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910