DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and lrrc4ca

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001018583.1	Gene:	lrrc4ca / 553785	ZFINID:	ZDB-GENE-050522-533	Length:	647	Species:	Danio rerio

Alignment Length:	749	Identity:	178/749 - (23%)
Similarity:	266/749 - (35%)	Gaps:	243/749 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 NSAQRRTLATKVRRKGPRPQRRLHPPLRPRLPLHLHLLLWLLCCCSQLGQLRAE-CPAVCECKWK 88
            :|..::|:      :|||..|.|..||     ..|.|.|.||...   |.:||: ||:||.|..:
Zfish     7 SSLMQQTM------RGPRWNRALSDPL-----FVLSLALQLLVVA---GLVRAQTCPSVCSCSNQ 57

  Fly    89 SGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIER 153
            ..|  |:|....|..:|..:...|:.|:|..|.||:|..|||  ..|.:|:.:.|::.|:|.||.
Zfish    58 FSK--VICTRRGLRDVPDGISTNTRYLNLQENLIQVIKVDSF--KHLRHLEILQLSKNHIRNIEI 118

  Fly   154 HAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDC 218
            .||..|.||..|:|..|.|:.||:.|..::|:|:||.|..|||..:|..||..||.|.:|:|.:.
Zfish   119 GAFNGLANLNTLELFDNRLTTIPNGAFEYLSKLKELWLRNNPIESIPSYAFNRVPSLRRLDLGEL 183

  Fly   219 -RLSHIAVRAFAGLES---------------------SLEWLKLDGNRLSEVRSGTITSL----- 256
             |||:|:..||.||.:                     .|:.|::.||:||.:|.|:...|
Zfish   184 KRLSYISEGAFEGLSNLRYLNLGMCNLKEIPNLIPLVRLDELEMSGNQLSIIRPGSFKGLVHLQK 248

  Fly   257 ----------------------------------------ASLHGLE---LARNTWNCSCSLRPL 278
                                                    ..||.||   |..|.|||:|.:..|
Zfish   249 LWMMHAQIQTIERNAFDDLQSLVELNLAHNNLTLLPHDLFTPLHHLERVHLHHNPWNCNCDILWL 313

  Fly   279 RAWMLQQNIPSGIP--PTCESPPRLSGRAWDKLDVDDFAC-VPQIVATDTTAHGVEGRNITMSCY 340
             :|.|::.:|:...  ..|.||....||...:||.:.|.| .|.||......:..||....:.|.
Zfish   314 -SWWLKEMVPANTSCCARCSSPTSHKGRYIGELDQNYFHCYAPVIVEPPADLNVTEGMAAELKCR 377

  Fly   341 VEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQD 405
            ...:  .:|.|:                   .|..:..|.|.....:::| |...|......|||
Zfish   378 ANSL--TSVSWI-------------------TPNGSIMTHGAYKIRISVL-NDGTLNFTNVTMQD 420

  Fly   406 AGIYTCAAENKAGKVEASVTLAVSRRPPEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRR 470
            .|.|||...|.||...||.||.||.                      ...|||:.....:::...
Zfish   421 TGTYTCMVSNSAGNTTASATLNVSS----------------------TENSSFSYFTTVTVETTE 463

  Fly   471 ------------------KLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLF 517
                              ...:|.::||     |:.....|||
Zfish   464 APPDEGHPTVQQKNGPTPSSGIWETLPP-----SFTTTTTTAR---------------------- 501

  Fly   518 HDAEEQGYLRAAHTPLND--NDAGQAAAIVNPSAGSAQRRN----------GDYLHVST------ 564
                         |||:.  .|......:...|.||....:          |.::.::.
Zfish   502 -------------TPLSTKATDKTYTIPVTAQSDGSLNTLDEVMKTTKIIIGCFVAITLMAAVML 553

  Fly   565 ---HCDDEEEDQQLHHHPQQQ--------------PASQHH------PHPNQQQHQQRKGSQGHV 606
               :...::..||.||.|.:.              ||.:.|      .|.:...:...|.:..|.
Zfish   554 IIFYKMRKQHHQQNHHAPTRAIEIINVDEDCMTGGPAMESHLALPPLDHEHLNHYNAYKTAYNHA 618

  Fly   607 VSASGANNSAPLEETDLHIPRLIDIGGTDSASSS 640
            .:.:..::||       |.|.||.....|:...:
Zfish   619 STINSIHSSA-------HEPLLIRASSKDNVQET 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	67/226 (30%)
		leucine-rich repeat	112..137	CDD:275380	11/24 (46%)
		LRR_8	137..196	CDD:290566	24/58 (41%)
		leucine-rich repeat	138..161	CDD:275380	9/22 (41%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	28/82 (34%)
		leucine-rich repeat	186..209	CDD:275380	11/22 (50%)
		leucine-rich repeat	210..234	CDD:275380	11/45 (24%)
		leucine-rich repeat	235..258	CDD:275380	9/67 (13%)
		LRRCT	267..316	CDD:214507	17/50 (34%)
		IG_like	328..428	CDD:214653	25/99 (25%)
		Ig	335..425	CDD:143165	21/89 (24%)
lrrc4ca	NP_001018583.1	LRRNT	48..81	CDD:214470	11/34 (32%)
		LRR	<78..288	CDD:227223	62/211 (29%)
		leucine-rich repeat	79..102	CDD:275380	11/24 (46%)
		leucine-rich repeat	103..126	CDD:275380	9/22 (41%)
		leucine-rich repeat	127..150	CDD:275380	8/22 (36%)
		leucine-rich repeat	151..174	CDD:275380	11/22 (50%)
		leucine-rich repeat	175..199	CDD:275380	11/23 (48%)
		leucine-rich repeat	200..221	CDD:275380	0/20 (0%)
		leucine-rich repeat	222..245	CDD:275380	9/22 (41%)
		leucine-rich repeat	246..269	CDD:275380	0/22 (0%)
		leucine-rich repeat	270..291	CDD:275380	0/20 (0%)
		LRRCT	302..>340	CDD:214507	12/38 (32%)
		IG	361..443	CDD:214652	25/103 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	45	1.000	Domainoid score	I12164
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8422
orthoMCL	1	0.900	-	-		OOG6_104601
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810