DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and LGI2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_060646.2	Gene:	LGI2 / 55203	HGNCID:	18710	Length:	545	Species:	Homo sapiens

Alignment Length:	329	Identity:	72/329 - (21%)
Similarity:	112/329 - (34%)	Gaps:	127/329 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LHLLLWLLCCCSQLGQLR--AECPAVCECKWKSGKESVLCLNAN--------------------- 100
            |.|||...|...:..|:|  |.|||.|.|.    |||::|:.::
Human    14 LLLLLGAACLIPRSAQVRRLARCPATCSCT----KESIICVGSSWVPRIVPGDISSLSLVNGTFS 74

  Fly   101 ------LTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKL 159
                  .:|:|     ..|||.|:.|...:|.||:|  |.|.:|:.:::....:..|.|:|||.|
Human    75 EIKDRMFSHLP-----SLQLLLLNSNSFTIIRDDAF--AGLFHLEYLFIEGNKIETISRNAFRGL 132

  Fly   160 INLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIA 224
            .:|..|.|:.|.:.|:|......:..|.||.|.||                 |.| .||:...:.
Human   133 RDLTHLSLANNHIKALPRDVFSDLDSLIELDLRGN-----------------KFE-CDCKAKWLY 179

  Fly   225 VRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPS 289
            :           |||:..:.:|:|
Human   180 L-----------WLKMTNSTVSDV----------------------------------------- 192

  Fly   290 GIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAH--------GVEGRNITMSCYVEGVPQ 346
                .|..||....:..:.:...|:.|    ..||...|        .|:..|.....|| .:.|
Human   193 ----LCIGPPEYQEKKLNDVTSFDYEC----TTTDFVVHQTLPYQSVSVDTFNSKNDVYV-AIAQ 248

  Fly   347 PAVK 350
            |:::
Human   249 PSME 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	39/156 (25%)
		leucine-rich repeat	112..137	CDD:275380	11/24 (46%)
		LRR_8	137..196	CDD:290566	19/58 (33%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	13/60 (22%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	4/23 (17%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	4/48 (8%)
		IG_like	328..428	CDD:214653	7/31 (23%)
		Ig	335..425	CDD:143165	4/16 (25%)
LGI2	NP_060646.2	LRR 1	86..107		9/22 (41%)
		LRR_8	110..169	CDD:404697	19/75 (25%)
		LRR 2	110..131		5/20 (25%)
		leucine-rich repeat	111..134	CDD:275378	7/22 (32%)
		LRR 3	134..155		6/20 (30%)
		leucine-rich repeat	135..158	CDD:275378	6/22 (27%)
		PCC	140..>215	CDD:188093	23/148 (16%)
		leucine-rich repeat	159..171	CDD:275378	8/29 (28%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	219..261		8/35 (23%)
		EPTP	219..258	CDD:397689	8/35 (23%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	265..307
		EPTP	266..304	CDD:397689
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	311..358
		EPTP	311..355	CDD:397689
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	360..403
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	407..450
		EPTP	407..447	CDD:397689
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	452..494
		EPTP	452..491	CDD:397689
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	498..540
		EPTP	499..537	CDD:397689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840