DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and islr2

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001013541.1	Gene:	islr2 / 541396	ZFINID:	ZDB-GENE-050320-95	Length:	712	Species:	Danio rerio

Alignment Length:	855	Identity:	182/855 - (21%)
Similarity:	299/855 - (34%)	Gaps:	215/855 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYL 143
            ||..|.|..|...:.|.|...:|..:|..|.:....|.||.|:|:::...:|  ..:..:..::|
Zfish    22 CPKQCACSDKYNHQFVDCAYKDLVEVPVGLPSNASTLSLSANKIKVLKSKTF--VNVTQVTSLWL 84

  Fly   144 ARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNPILRVPDDAFGHVP 208
            |...:..:||.....||.|..||:|.|.:...|...|.::..|:.|:::.|.::.:|.:||.:
Zfish    85 AHNEIITVERDTLAPLIQLKNLDISNNKIVHFPWEDLANLGALQLLKMNNNEMVSIPKNAFSN-- 147

  Fly   209 QLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSC 273
                  |.|.|.                 ::::.|:.:.:..||..|||::..|::..|.:.|||
Zfish   148 ------LKDLRS-----------------IRINNNKFTTIVQGTFDSLAAMSHLQIFHNPFICSC 189

  Fly   274 SLRPLRAWMLQQNIPSGIPP----TCESPPRLSG---RAWDKLDVD----DFACVPQIVATDTTA 327
            :|..||.|:|:.:|  .||.    .|::|..|.|   .:..||:..    .....|.|..|:.
Zfish   190 NLEWLRDWILKSSI--SIPEQNNIACDAPSHLKGSQVTSMPKLNCKAPSVSITYQPNIEKTEL-- 250

  Fly   328 HGVEGRNITMSCYVEGVPQPAVKW--LLKNRLIANLSAGGDGDSDSEPRTAAATQ------GRKT 384
              .||..:.:.|..:|.|:|.|.|  ...|:||            :.|..|...:      |..|
Zfish   251 --YEGYMVMLYCETKGTPKPEVTWEIFAGNQLI------------TFPLPAIVEKSDIPINGPPT 301

  Fly   385 YVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAV-------------SRRP---P 433
            ....::.....|.:.....::.|.|||:|.|..||.|:||.|.|             ::.|   |
Zfish   302 NTRFLVFQNGTLIVPRMSKKEEGNYTCSAVNDIGKAESSVRLVVAGTKKHATNSMLDTKSPGLLP 366

  Fly   434 EAPWGVRIILLGAVAALLLVGGSSFAAICLCSL--QRRRKLRLWNSVPPVRRSESYEKIEMTART 496
            |...|.:              ||..:.|.:...  ::.:.|....||..|.:    |:::..|.|
Zfish   367 EDKLGSK--------------GSKNSVISMRPKFEEKTKSLPTGTSVITVDK----EQVDEGADT 413

  Fly   497 RPDLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLH 561
            .|.:|   .||                         :||.....:....|.|....::...|:..
Zfish   414 LPFVG---KCG-------------------------INDGTQYISNHAFNLSLDELKQYTFDFGV 450

  Fly   562 VSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSASGANNSAPLEETDLHIP 626
            ::....:.|...||  :|.|...::.:.|.:|||..|....:...:..:.|..| ||:...|
Zfish   451 IALEVSETEAKVQL--NPMQMANAKSNIHLSQQQDLQTVNKEPFSLFQTSAKKS-PLDLLYL--- 509

  Fly   627 RLIDIGGTDSASSSISSQVDAAARLAGYAGHT---WKTTPIATTKINSPHSKPVTSAAPSSLNTQ 688
             .:..|.                      ||:   |.............|.||         .|.
Zfish   510 -CVSTGN----------------------GHSVVQWSKIEEGVNAYRFQHLKP---------GTN 542

  Fly   689 ATPYAHYGNHPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEGRGQGYAQATTTPN 753
            .|....||..  |.....||.:.        ...|.||.|...::..         .|.||....
Zfish   543 YTLCLTYGGQ--DCQVQVVFTTR--------KKIPSLLIIVVVSIFL---------LALATVPLL 588

  Fly   754 GGLCTLPRKLKTSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGSFLNEAMGLGRRYSAESSYANY 818
            |..| .....|..||.::....:|:|   |...|            |.|.....|.|...|..|:
Zfish   589 GATC-CHLLYKYQGKTYKLIMKTQNP---DQMEK------------NIATDFDPRASFVGSEKNF 637

  Fly   819 SSTATYTGGGQRANSFLNLVQSGAHQGKLLPSHLGQKPSLPSSPVQHQRSLSSAATPLLDFSALA 883
            :.:....|.|:...      :.|..:|:.:...:..: |:|.|..:.|......:    ::|...
Zfish   638 NPSEMGEGEGEADG------EEGDGEGEDIEGSVVTE-SIPESQSKTQEEFEVGS----EYSDRL 691

  Fly   884 SRAAGAANTS 893
            ...|.|.|.|
Zfish   692 PLGAEAVNIS 701

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	35/156 (22%)
		leucine-rich repeat	112..137	CDD:275380	6/24 (25%)
		LRR_8	137..196	CDD:290566	16/58 (28%)
		leucine-rich repeat	138..161	CDD:275380	5/22 (23%)
		leucine-rich repeat	162..185	CDD:275380	7/22 (32%)
		LRR_8	184..245	CDD:290566	10/60 (17%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	3/23 (13%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	18/59 (31%)
		IG_like	328..428	CDD:214653	28/107 (26%)
		Ig	335..425	CDD:143165	24/97 (25%)
islr2	NP_001013541.1	leucine-rich repeat	35..53	CDD:275380	5/17 (29%)
		LRR_RI	<47..>184	CDD:238064	37/163 (23%)
		LRR_8	53..113	CDD:290566	17/61 (28%)
		leucine-rich repeat	57..78	CDD:275380	6/22 (27%)
		leucine-rich repeat	79..102	CDD:275380	5/22 (23%)
		LRR_8	102..161	CDD:290566	17/83 (20%)
		leucine-rich repeat	103..126	CDD:275380	7/22 (32%)
		leucine-rich repeat	127..150	CDD:275380	7/30 (23%)
		leucine-rich repeat	151..174	CDD:275380	6/39 (15%)
		LRRCT	183..>221	CDD:214507	15/39 (38%)
		IG_like	252..345	CDD:214653	28/104 (27%)
		Ig	256..345	CDD:299845	26/100 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910