DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lrit3

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_006232069.1	Gene:	Lrit3 / 502596	RGDID:	1559637	Length:	702	Species:	Rattus norvegicus

Alignment Length:	755	Identity:	165/755 - (21%)
Similarity:	260/755 - (34%)	Gaps:	237/755 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LWLLCC-C---SQLGQLRAECPAVCECKWK-----SGKESVLCLNANLTHIPQPLDAGTQLLDLS 118
            :||..| |   |.||.:...||:.|.|::.     ||..||||.:.::..:|..|...|..|.:.
  Rat     1 MWLFACLCLVLSFLGGVNCTCPSQCSCEYHGRHEGSGSRSVLCNDLDMNEVPTNLPVDTAKLRIE 65

  Fly   119 GNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHV 183
            ...::.||.::|  ..|:.||.::|....:..||..:|..|..|.||.|..|.|:..|..:|..:
  Rat    66 KTVVRRIPAEAF--YYLVELQYLWLTYNSVASIETRSFYNLKQLHELRLDGNSLTEFPWASLLDM 128

  Fly   184 SELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRL-----------SHIAVRAFAGLESSLEW 237
            ..||.|.|..|.|..|.::|..::..|..|:||..||           ||:|
  Rat   129 PHLRTLDLHNNRITSVTNEAVRYLRNLTCLDLSSNRLTTLPPDFLDSWSHLA------------- 180

  Fly   238 LKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSL-RPLRAWMLQQNIPSGIPP--TCESPP 299
                   ::..||..:.....:.||:  .|.|.|.|.: :.:....:..:....:.|  .|..|.
  Rat   181 -------MTPSRSPDLPPKRIILGLQ--DNPWFCDCHISKVIELSKVADHAAVLLDPLMVCSEPE 236

  Fly   300 RLSGRAWDKLDVDDFACV-PQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSA 363
            .|.|.|:.:::::  .|: |.::.:.|......|.|:.:.|..:|.|.|.:.|.
  Rat   237 YLQGIAFQRVELE--KCLKPSVMMSATKITSALGSNVLLRCDAKGYPTPQLMWT----------- 288

  Fly   364 GGDGDSDSEPRTAAATQGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAV 428
                .|||.|..|...|......|..    |.|::.....:|||.|:|.|:|.||..||.||:.|
  Rat   289 ----RSDSSPVNATVIQESPGEGVRW----SILSLTGITYRDAGDYSCKAKNLAGTSEAVVTVTV 345

  Fly   429 -------------SRRPPEAP------------------WGVRIILLGAVAALLLVGGSSFAAIC 462
                         .|.|.|.|                  |     |...::.......||.||:.
  Rat   346 VGVATTTLSPDTSERSPGEHPEQNHPQPGLGRSTPQSKSW-----LWPGLSYTSSHPTSSAAALS 405

  Fly   463 LCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDAEEQGYLR 527
            ..:|....     :|:||:     :.....|...|..:.|..                     :|
  Rat   406 TSTLSPPP-----SSLPPI-----FSAASATTSVRTSISGST---------------------VR 439

  Fly   528 AAHTPLNDNDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPN 592
            .:|.|                                                  |..  ||...
  Rat   440 TSHRP--------------------------------------------------PLL--HPGGK 452

  Fly   593 QQQHQQRKGSQGHVVSASG------ANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVDAAARL 651
            .....::.|.:...:|||.      .:.:||: ||::.|..|           .::.:..|:..|
  Rat   453 SNAKIEKNGRKFPPLSASKKEELALMDQAAPM-ETNITIKDL-----------RVARETGASVTL 505

  Fly   652 AGYAGHTWKTTPIATTKINSPHSKPVTSAAPSSLNTQATPYAHYGNHPADEMATSVFCSEGQESD 716
                  ||.::..:::..:|..|...:|::.||:               .|.|.:|..|:..|.|
  Rat   506 ------TWSSSSSSSSSSSSSSSSSSSSSSSSSI---------------QESAVTVLYSKYGEKD 549

  Fly   717 LFDSNYPDLLDIAKYAVAQAQQEG--RGQGYAQATTTPNG 754
            |       ||..|.|...||...|  .|..|. |...|.|
  Rat   550 L-------LLVDADYGKNQATINGLEPGSQYV-ACVCPKG 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	42/167 (25%)
		leucine-rich repeat	112..137	CDD:275380	6/24 (25%)
		LRR_8	137..196	CDD:290566	20/58 (34%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	17/71 (24%)
		leucine-rich repeat	186..209	CDD:275380	8/22 (36%)
		leucine-rich repeat	210..234	CDD:275380	9/34 (26%)
		leucine-rich repeat	235..258	CDD:275380	2/22 (9%)
		LRRCT	267..316	CDD:214507	10/51 (20%)
		IG_like	328..428	CDD:214653	29/99 (29%)
		Ig	335..425	CDD:143165	25/89 (28%)
Lrit3	XP_006232069.1	LRR_8	61..117	CDD:290566	17/57 (30%)
		LRR_4	83..121	CDD:289563	13/37 (35%)
		leucine-rich repeat	83..106	CDD:275378	7/22 (32%)
		LRR_8	105..165	CDD:290566	20/59 (34%)
		LRR_4	105..146	CDD:289563	15/40 (38%)
		leucine-rich repeat	107..130	CDD:275378	8/22 (36%)
		LRR_4	129..170	CDD:289563	14/40 (35%)
		leucine-rich repeat	131..154	CDD:275378	8/22 (36%)
		leucine-rich repeat	155..168	CDD:275378	6/12 (50%)
		IGc2	268..335	CDD:197706	23/85 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334988
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840