DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and Lrrn1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001032440.1	Gene:	Lrrn1 / 500280	RGDID:	1564145	Length:	716	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	103/517 - (19%)
Similarity:	169/517 - (32%)	Gaps:	189/517 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 LRAECPAVCECK---WKSGKE------SVLCLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDD-- 128
            |.:|||.:|.|:   |.:.:.      :|.|.:..||.||..|.:.||:|.|..|.|....|:
  Rat    28 LNSECPQLCVCEIRPWFTPQSTYREATTVDCNDLRLTRIPGNLSSDTQVLLLQSNNIAKTVDELQ 92

  Fly   129 -------------------------------------------SFATAQLLNLQKVYLARCHLRL 150
                                                       .:....|.|||::|:....:..
  Rat    93 QLFNLTELDFSQNNFTNIKEVGLANLTQLTTLHLEENQISEMTDYCLQDLSNLQELYINHNQISS 157

  Fly   151 IERHAFRKLINLVELDLSQNLLSAI---------------------------------------- 175
            |..:||..|.||:.|.|:.|.|..|
  Rat   158 ISANAFSGLKNLLRLHLNSNKLKVIDSRWFDSTPNLEILMIGENPVIGILDMNFRPLSNLRSLVL 222

  Fly   176 --------------------------------PSLALYHVSELRELRLSGNPILRVPDD------ 202
                                            |.|||..|..|:.|.|:.|||.::.:.
  Rat   223 AGMYLTDIPGNALVGLDSLESLSFYDNKLIKVPQLALQKVPNLKFLDLNKNPIHKIQEGDFKNML 287

  Fly   203 -------------------AFGHVPQLVKLE-LSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSE 247
                               |..::|:|.||| .::.:||:|...||..: .:||.|.|:.|.|:.
  Rat   288 RLKELGINNMGELVSVDRYALDNLPELTKLEATNNPKLSYIHRLAFRSV-PALESLMLNNNALNA 351

  Fly   248 VRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSGIPPTCESPPRLSGRAWDKLDVD 312
            |...|:.||.:|..:.:..|...|.|.:..:.:..........:...|..||...|:...::.:.
  Rat   352 VYQKTVESLPNLREISIHSNPLRCDCVIHWINSNKTNIRFMEPLSMFCAMPPEYRGQQVKEVLIQ 416

  Fly   313 DFA--CVPQIVATDTTAHGVE---GRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSE 372
            |.:  |:| :::.||..:.:.   |..:.:.|.....|:|.:.|:
  Rat   417 DSSEQCLP-MISHDTFPNHLNMDIGTTLFLDCRAMAEPEPEIYWV-------------------- 460

  Fly   373 PRTAAATQGRKTYVVNM-----LRNASNLTILTADMQDAGIYTCAAENKAGKVEASVTLAVS 429
                 ...|.|..|..:     |.:...|.|....::|:|.|||.|:|..|......|:.|:
  Rat   461 -----TPIGNKITVETLSDKYKLSSEGTLEIANIQIEDSGRYTCVAQNVQGADTRVATIKVN 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	56/299 (19%)
		leucine-rich repeat	112..137	CDD:275380	8/69 (12%)
		LRR_8	137..196	CDD:290566	24/130 (18%)
		leucine-rich repeat	138..161	CDD:275380	7/22 (32%)
		leucine-rich repeat	162..185	CDD:275380	11/94 (12%)
		LRR_8	184..245	CDD:290566	22/86 (26%)
		leucine-rich repeat	186..209	CDD:275380	7/47 (15%)
		leucine-rich repeat	210..234	CDD:275380	9/24 (38%)
		leucine-rich repeat	235..258	CDD:275380	10/22 (45%)
		LRRCT	267..316	CDD:214507	8/50 (16%)
		IG_like	328..428	CDD:214653	20/107 (19%)
		Ig	335..425	CDD:143165	18/94 (19%)
Lrrn1	NP_001032440.1	leucine-rich repeat	54..73	CDD:275380	7/18 (39%)
		LRR	<68..372	CDD:227223	57/304 (19%)
		LRR 1	73..95		7/21 (33%)
		leucine-rich repeat	74..96	CDD:275380	7/21 (33%)
		LRR 2	96..117		0/20 (0%)
		leucine-rich repeat	97..120	CDD:275380	0/22 (0%)
		LRR 3	120..141		0/20 (0%)
		leucine-rich repeat	121..144	CDD:275380	1/22 (5%)
		LRR 4	144..165		7/20 (35%)
		leucine-rich repeat	145..168	CDD:275380	7/22 (32%)
		LRR 5	168..189		7/20 (35%)
		leucine-rich repeat	169..192	CDD:275380	6/22 (27%)
		LRR 6	192..213		0/20 (0%)
		leucine-rich repeat	193..216	CDD:275380	0/22 (0%)
		LRR 7	216..237		0/20 (0%)
		leucine-rich repeat	217..240	CDD:275380	0/22 (0%)
		LRR 8	240..261		4/20 (20%)
		leucine-rich repeat	241..264	CDD:275380	5/22 (23%)
		LRR 9	264..285		6/20 (30%)
		leucine-rich repeat	265..288	CDD:275380	6/22 (27%)
		leucine-rich repeat	289..313	CDD:275380	1/23 (4%)
		leucine-rich repeat	314..335	CDD:275380	9/20 (45%)
		leucine-rich repeat	339..362	CDD:275378	10/22 (45%)
		leucine-rich repeat	363..375	CDD:275378	2/11 (18%)
		LRRCT	371..419	CDD:214507	8/47 (17%)
		I-set	429..516	CDD:400151	22/111 (20%)
		Ig strand A'	433..438	CDD:409353	0/4 (0%)
		Ig strand B	441..450	CDD:409353	1/8 (13%)
		Ig strand C	456..460	CDD:409353	0/3 (0%)
		Ig strand C'	463..465	CDD:409353	0/1 (0%)
		Ig strand D	478..481	CDD:409353	1/2 (50%)
		Ig strand E	482..487	CDD:409353	1/4 (25%)
		Ig strand F	495..503	CDD:409353	5/7 (71%)
		Ig strand G	506..516	CDD:409353	2/9 (22%)
		FN3	531..600	CDD:214495
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..716
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9069
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000