DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and Lgr6

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	XP_573455.1	Gene:	Lgr6 / 498233	RGDID:	1560339	Length:	965	Species:	Rattus norvegicus

Alignment Length:	1128	Identity:	244/1128 - (21%)
Similarity:	356/1128 - (31%)	Gaps:	351/1128 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 LHLHLLLWLLCCC------------SQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLD 109
            :|...||..||.|            .|.|..|..|||.|.|:......|..|....|:.:|..||
  Rat     1 MHSSPLLLALCLCVVLCALARAGSDPQPGPGRPACPAPCHCQEDGIMLSADCSELGLSEVPADLD 65

  Fly   110 AGTQLLDLSGNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSA 174
            ..|..||||.|.:..:....|  ..|..|:::.|:..||..|.|.||..|.:|..|.|..|.|..
  Rat    66 PLTAYLDLSMNNLTELQPGLF--HHLRFLEELRLSGNHLSHIPRQAFSGLHSLKILMLQSNQLRG 128

  Fly   175 IPSLALYHVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLE------- 232
            ||:.||:.:..|:.|||..|.|..||:.:|..:..|..|.|.|..|:.|.|||...|.
  Rat   129 IPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTL 193

  Fly   233 ----------------SSLEWLKLDGNRLSEVRSGTITSLASLHGLELARNTWNCSCSLRPLRAW 281
                            :||..|.|..||:..|.:.:...|.:|..|:|..|.
  Rat   194 ALNRIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNE------------- 245

  Fly   282 MLQQNIPSGIPPTCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGVEGRNI----------- 335
              .|..|..|        |..||..:.                    |....||
  Rat   246 --LQEFPVAI--------RTLGRLQEL--------------------GFHNNNIKAIPEKAFMGN 280

  Fly   336 ----TMSCY---VEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNA 393
                |:..|   ::.|.:.|.::|.|   :..||..|..|....|.               |:..
  Rat   281 PLLQTIHFYDNPIQFVGRSAFQYLSK---LHTLSLNGATDIQEFPD---------------LKGT 327

  Fly   394 SNLTILTADMQDAGIYTCAA------------ENKAGKVEASVTLAVSRRPPEAP------WGVR 440
            ::|.|||  :..|||....|            |....::|...:|...::..|..      |.
  Rat   328 TSLEILT--LTRAGIRLLPAGMCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLQHNRIWE-- 388

  Fly   441 IILLGAVAALLLVGGSSFAAICLCSLQRRRKLRL-WNSVPPVRRS-----ESYEKIEMT---ART 496
                        :|..:|:.  |.|||   .|.| ||::..:...     .|..|:::|   ..|
  Rat   389 ------------IGADTFSQ--LSSLQ---ALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTT 436

  Fly   497 RPDLGGGASCGGGSATGAGLFH------DAEEQGY-------LRAAHTPLNDNDAGQAAA---IV 545
            .|..|.|           ||.|      .|..|.:       ||....|.    |.|..|   ..
  Rat   437 LPLAGLG-----------GLMHLKLKGNLALSQAFSKDSFPKLRILEVPY----AYQCCAYGLCA 486

  Fly   546 NPSAGSAQRRNGDYLHVSTHCDDEEEDQ--------QLHHH------PQQQPASQHHPHPNQQ-- 594
            |....|.|.:..|:     |.::||..:        |..:|      ..|.......|||:.|
  Rat   487 NFFKTSGQWQAEDF-----HAEEEEAPKRPLGLLAGQAENHYDLDLDELQMETEDSKPHPSVQCS 546

  Fly   595 ---------QHQQRKGS---------------QGHVVSASGANNSAPLEETDLHIPRLIDIGGTD 635
                     :|......               .|.|:....|...:||....|.:..:.......
  Rat   547 PVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPSPLSPVKLVVGAIAGANALT 611

  Fly   636 SASSSISSQVDAA--ARLAGYAGHTWKT------TPIATTKINSPHSKPVTSAAPSSLNTQATPY 692
            ..|..:.:.|||.  .:.|.| |..|:|      |..... :.|..|..:.:.|....:...|..
  Rat   612 GISCGLLASVDALTFGQFAEY-GARWETGLGCQATGFLAV-LGSEASVLLLTLAAVQCSVSVTCV 674

  Fly   693 AHYGNHPADEM----ATSVFCSEGQESDLFDSNYPDLLDIAKYAVA-----QAQQEGR--GQGYA 746
            ..||..|:...    |.......|..:.|      .|..:.:|..:     .|..|||  ..|:|
  Rat   675 RAYGKAPSPGSVRAGALGCLALAGLAAAL------PLASVGEYGASPLCLPYAPPEGRPAALGFA 733

  Fly   747 QATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGSFLNEAMGLGRRYSA 811
            .|....| .||.    |..:|.|.:...|...   .|..:.:..:.:...::|..|.||.....|
  Rat   734 VALVMMN-SLCF----LVVAGAYIKLYCDLPR---GDFEAVWDCAMVRHVAWLIFADGLLYCPVA 790

  Fly   812 ESSYANYSSTATYTGGGQRANSFLNLVQSGAHQGKLLPSHLGQKPSLPSSPVQH-----QRSLSS 871
            ..|:|  |....:....:...|.|.:|..       ||:.|.....|..:|  |     :|...|
  Rat   791 FLSFA--SMLGLFPVTPEAVKSVLLVVLP-------LPACLNPLLYLLFNP--HFREDLRRLWPS 844

  Fly   872 AATPLLDFSALASRAAGAANTSVAAYDYHAAQLERFLEEYRNLQDQLCKMKETCDTIRKKETPLR 936
            ..:|    ..||..|||              :||                |.:||:.
  Rat   845 PRSP----GPLAYTAAG--------------ELE----------------KSSCDST-------- 867

  Fly   937 VAIGQSAAQLADPVMYSAASHSPKPPA--TSNLKTKTLLPGQPPDPPPYWLHRNAMLKRLNGDGS 999
                |:....:|..:...||.:.:||.  |....:.||:....|.           ..||.|:..
  Rat   868 ----QALVAFSDVDLILEASEAGQPPGLETYGFPSVTLISRHQPG-----------ATRLEGNHF 917

  Fly  1000 AGTNGSG-GSPASPQPRQDIFKS 1021
            ...:|:. |:|..|...:.:.::
  Rat   918 VEPDGTKLGNPQPPMNEELLLRA 940

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	56/179 (31%)
		leucine-rich repeat	112..137	CDD:275380	8/24 (33%)
		LRR_8	137..196	CDD:290566	23/58 (40%)
		leucine-rich repeat	138..161	CDD:275380	9/22 (41%)
		leucine-rich repeat	162..185	CDD:275380	9/22 (41%)
		LRR_8	184..245	CDD:290566	24/83 (29%)
		leucine-rich repeat	186..209	CDD:275380	9/22 (41%)
		leucine-rich repeat	210..234	CDD:275380	10/46 (22%)
		leucine-rich repeat	235..258	CDD:275380	7/22 (32%)
		LRRCT	267..316	CDD:214507	7/48 (15%)
		IG_like	328..428	CDD:214653	26/129 (20%)
		Ig	335..425	CDD:143165	23/119 (19%)
Lgr6	XP_573455.1	LRRNT	34..68	CDD:214470	11/33 (33%)
		LRR_RI	<70..248	CDD:238064	56/194 (29%)
		leucine-rich repeat	70..91	CDD:275380	7/22 (32%)
		LRR_8	92..150	CDD:290566	23/57 (40%)
		leucine-rich repeat	92..115	CDD:275380	9/22 (41%)
		leucine-rich repeat	116..139	CDD:275380	9/22 (41%)
		LRR_8	138..198	CDD:290566	19/59 (32%)
		leucine-rich repeat	140..163	CDD:275380	9/22 (41%)
		leucine-rich repeat	164..187	CDD:275380	10/22 (45%)
		LRR_8	186..246	CDD:290566	12/74 (16%)
		leucine-rich repeat	188..211	CDD:275380	0/22 (0%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..258	CDD:275380	8/44 (18%)
		LRR_RI	253..>442	CDD:238064	47/255 (18%)
		LRR_8	258..314	CDD:290566	12/78 (15%)
		leucine-rich repeat	259..282	CDD:275380	3/42 (7%)
		leucine-rich repeat	283..304	CDD:275380	4/20 (20%)
		LRR_8	305..364	CDD:290566	16/78 (21%)
		leucine-rich repeat	330..344	CDD:275378	7/15 (47%)
		leucine-rich repeat	354..375	CDD:275380	3/20 (15%)
		LRR_8	375..434	CDD:290566	15/77 (19%)
		leucine-rich repeat	376..399	CDD:275380	5/38 (13%)
		leucine-rich repeat	400..421	CDD:275380	6/23 (26%)
		leucine-rich repeat	424..444	CDD:275380	6/30 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334976
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840