DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and pxdn

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001076815.1	Gene:	pxdn / 493201	XenbaseID:	XB-GENE-923300	Length:	1460	Species:	Xenopus tropicalis

Alignment Length:	925	Identity:	200/925 - (21%)
Similarity:	310/925 - (33%)	Gaps:	298/925 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LHLLLWLLCCCSQLGQLRAECPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDLSGNEIQ 123
            |:|...||...  |.||...||:.|.|    .:.:|.|::..|..:| .:...|.:|||..|.|:
Frog    11 LYLTAGLLVVA--LPQLSHSCPSRCLC----FRTTVRCMHLMLESVP-AVPPHTTILDLRFNRIK 68

  Fly   124 LIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRE 188
            .|...:|  ..|.||..:.|....::.|...||:.|.||..|.|.:|.:.:|...|...::.|.:
Frog    69 DIQTGAF--KHLKNLNTLLLNNNQIKRIPSEAFKDLENLKYLYLYKNEIQSIDRQAFKGLASLEQ 131

  Fly   189 LRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEVRSGTI 253
            |.|..|.|..:..::|.::|:|.:|.|.:.|::|:....|:.|| |::.|:||.|.|
Frog   132 LYLHFNQIETLEPESFNYLPKLERLFLHNNRITHLVPGTFSQLE-SMKRLRLDSNAL-------- 187

  Fly   254 TSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIPSG---IPPTCESPPRLSGRAWDKLDVDDFA 315
                            :|.|.:..| |.:|:....||   ...|||.|.||.||:...:...:..
Frog   188 ----------------HCDCEILWL-ADLLKIYSESGNAQAAATCEYPRRLQGRSVSTITPSELN 235

  Fly   316 CV-PQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAAT 379
            |. |:|.:.........|..:..:|..||.|:|.:.||..|.   .||...|..
Frog   236 CERPRITSEPQDVDVTFGNTVYFTCRAEGNPKPEIIWLRNNN---ELSMKDDSR----------- 286

  Fly   380 QGRKTYVVNMLRNASNLTILTADMQDAGIYTCAAENKAGKVEA-SVTLAVSRRPPE-----APWG 438
                   :|:| |...|.|......|.|||.|.|:|.||:|:. .|||.....|..     .|..
Frog   287 -------LNLL-NDGTLMIQNTKETDQGIYQCMAKNVAGEVKTHEVTLRYYGTPATPTFVIQPQN 343

  Fly   439 VRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRRSE-----SYEKIEMTARTRP 498
            ..:::           |.|....|..:.|...:: .|.      |.:     |..:|.:|.
Frog   344 TEVLV-----------GESVTLECSATGQPHPRV-TWT------RGDRTPLPSDPRINITP---- 386

  Fly   499 DLGGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAIVNPSAGS------------ 551
              .||.                    |::    .:|.:|||:.......|..:
Frog   387 --SGGL--------------------YIQ----NVNQDDAGEYTCFATNSVETIHSTAYIIVQAV 425

  Fly   552 ------AQRRNGDYLH-VSTHCDDEEEDQQLHHHPQQQPASQHHPHP--------NQQQHQQRKG 601
                  .|.||....| |..||:                 :|.:|.|        ||....:|
Frog   426 PQFTVVPQDRNVFEGHTVDFHCE-----------------AQGNPKPVIAWTKGGNQLSVDRR-- 471

  Fly   602 SQGHVVSASGANN--SAPLEETDLHIPRLIDIGGTDSASSSI----------------------- 641
               |.|.:||...  ...|.:...:..:.::|.|:.|.::.:
Frog   472 ---HQVLSSGTLRILRVALHDQGQYECQAVNIVGSKSTAAQLIVQTRVTPVFATVPNDMTVEVGT 533

  Fly   642 ------SSQVDAAARLAGYAGHTWKTTPIATTKIN----SPHS--------------------KP 676
                  |||.|....:      ||....|..|:..    |||.                    .|
Frog   534 DVQIPCSSQGDPLPII------TWNKDGIQVTESGKFHISPHGYLAIRDAGLADQGRYECVARNP 592

  Fly   677 VTSAAPSSLNTQATPYAHYGNHPADEMATSVF--------CSEGQESDLFDSNYP----DLLDIA 729
            :..::.|.:.:...|.......|.  :|||:.        ......:.||||. |    |||.:.
Frog   593 IGYSSVSMVLSVLVPEVSRTGDPF--VATSIIEAIATVDRAINSTRTHLFDSR-PRSPGDLLALF 654

  Fly   730 K-----YAVAQAQQEGRGQGYAQATTTPNGGLCTLPRKLKTSGKYFRNS-----SDSQSPLLAD- 783
            :     |.|.||:                            :.:.|..:     ...||.|:.|
Frog   655 RYPRDPYTVEQAR----------------------------AAEIFERTLQLIQDHVQSGLMVDL 691

  Fly   784 NSSKYGSSTLGDGSFLNEAMGLG-----RRYSAESSYANYSSTATYTG---------GGQRANSF 834
            |.:.|..:.|....:||....|.     ||.:..|:...:....|:.|         .|....:|
Frog   692 NGTSYHYNDLVSPQYLNMIANLSGCATHRRINNCSNMCFHQKYRTHDGTCNNLQHPMWGASLTAF 756

  Fly   835 LNLVQSGAHQGKLLP 849
            ..|::|....|..||
Frog   757 ERLLKSVYENGFNLP 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	44/156 (28%)
		leucine-rich repeat	112..137	CDD:275380	9/24 (38%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	20/60 (33%)
		leucine-rich repeat	186..209	CDD:275380	6/22 (27%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	5/22 (23%)
		LRRCT	267..316	CDD:214507	15/51 (29%)
		IG_like	328..428	CDD:214653	30/100 (30%)
		Ig	335..425	CDD:143165	26/90 (29%)
pxdn	NP_001076815.1	leucine-rich repeat	38..56	CDD:275380	4/18 (22%)
		LRR	<54..235	CDD:227223	59/208 (28%)
		leucine-rich repeat	57..80	CDD:275380	9/24 (38%)
		LRR_8	104..163	CDD:338972	17/58 (29%)
		leucine-rich repeat	105..128	CDD:275378	6/22 (27%)
		leucine-rich repeat	129..152	CDD:275378	6/22 (27%)
		leucine-rich repeat	153..176	CDD:275378	8/23 (35%)
		leucine-rich repeat	177..189	CDD:275378	5/35 (14%)
		I-set	239..326	CDD:369462	30/108 (28%)
		I-set	335..422	CDD:369462	18/134 (13%)
		Ig3_Peroxidasin	439..512	CDD:143222	18/94 (19%)
		Ig4_Peroxidasin	535..603	CDD:143223	13/73 (18%)
		peroxidasin_like	856..1295	CDD:188658
		VWC	1402..1452	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910