DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and LRRC24

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001019849.2	Gene:	LRRC24 / 441381	HGNCID:	28947	Length:	513	Species:	Homo sapiens

Alignment Length:	548	Identity:	159/548 - (29%)
Similarity:	218/548 - (39%)	Gaps:	135/548 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 RLPLHLHLLLWLLCCCSQLGQLRAE-CPAVCECKWKSGKESVLCLNANLTHIPQPLDAGTQLLDL 117
            |.|..|.|||.||       .|||. |||.|.|.    ..:|.|....|..:|..:..|||.|.|
Human     4 RAPALLPLLLLLL-------PLRAAGCPAACRCY----SATVECGALRLRVVPLGIPPGTQTLFL 57

  Fly   118 SGNEI-QLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALY 181
            ..|.| :|.|.   |.|.|..|:::||....||.:|..|||....|:||.|:.|.|..:.|.|..
Human    58 QDNNIARLEPG---ALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALTSNRLRGLRSGAFV 119

  Fly   182 HVSELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLS 246
            .:::||.|.|:||.:.|:.|..|.|:|:|.:|.|.:..:..:..:|.||| |||..|.|..|:|.
Human   120 GLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQALAGL-SSLALLDLSRNQLG 183

  Fly   247 EVRSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQ----------QNIPSGIPPTCESPPRL 301
            .:....:..||||..|.|..|.|.|.|:|..|.||:.:          :.|      .|..||||
Human   184 TISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRLLTSRDRKI------MCAEPPRL 242

  Fly   302 SGRAWDKLDVDDFACVP---QIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLKNRLIANLSA 363
            :.::...:......|:|   .:...:.||:  .|.::.::|...|.|||.|.|    |.:.....
Human   243 ALQSLLDVSHSSLICIPPSVHVQPLELTAN--LGEDLRVACQASGYPQPLVTW----RKVPQPRE 301

  Fly   364 GGDGDSDSEPRTAAATQGRKTYVVNML----RNASN-----LTILTADMQDAGIYTCAAENKAGK 419
            |       .||..|..:|      .:|    .:||:     |.:....:..||.|.|.|.|..|.
Human   302 G-------RPRAQAQLEG------GLLGLGGHSASDTGSGMLFLSNITLAHAGKYECEASNAGGA 353

  Fly   420 VEASVTLAV--SRRPPEAP--------------------------WGV-------RIILLGAVAA 449
            ......|.|  ||:.|:.|                          .||       ..|.|.|:.|
Human   354 ARVPFRLLVNASRQQPQQPAQPPPPAARPAGSEPRPEAGSMAFRALGVATQTAIAAAIALLALTA 418

  Fly   450 LLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVR---------------------RSESYEKIEMT 493
            ||||     |.||     |||:.|.....||..                     |.|...::.:.
Human   419 LLLV-----AMIC-----RRRRRRKKARGPPGEGALFVNDYLDGPCTFAQLEELRDERGHEMFVI 473

  Fly   494 ARTRPDLGGG-----ASCGGGSATGAGL 516
            .|::|....|     |.||.....|.||
Human   474 NRSKPLFAEGPAEAPADCGPEQGAGPGL 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	60/157 (38%)
		leucine-rich repeat	112..137	CDD:275380	11/25 (44%)
		LRR_8	137..196	CDD:290566	23/58 (40%)
		leucine-rich repeat	138..161	CDD:275380	9/22 (41%)
		leucine-rich repeat	162..185	CDD:275380	8/22 (36%)
		LRR_8	184..245	CDD:290566	24/60 (40%)
		leucine-rich repeat	186..209	CDD:275380	10/22 (45%)
		leucine-rich repeat	210..234	CDD:275380	7/23 (30%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	14/58 (24%)
		IG_like	328..428	CDD:214653	26/108 (24%)
		Ig	335..425	CDD:143165	24/98 (24%)
LRRC24	NP_001019849.2	LRR_RI	49..>158	CDD:238064	43/111 (39%)
		LRR_8	<50..86	CDD:290566	15/38 (39%)
		LRR 1	51..72		10/23 (43%)
		leucine-rich repeat	53..75	CDD:275380	10/24 (42%)
		LRR 2	75..96		8/20 (40%)
		LRR_8	76..134	CDD:290566	23/57 (40%)
		leucine-rich repeat	76..99	CDD:275380	9/22 (41%)
		LRR 3	99..120		8/20 (40%)
		leucine-rich repeat	100..123	CDD:275380	8/22 (36%)
		LRR_8	123..205	CDD:290566	31/82 (38%)
		LRR 4	123..144		9/20 (45%)
		leucine-rich repeat	124..147	CDD:275380	10/22 (45%)
		LRR 5	147..168		4/20 (20%)
		leucine-rich repeat	148..171	CDD:275380	7/23 (30%)
		LRR 6	171..192		6/20 (30%)
		leucine-rich repeat	172..195	CDD:275380	6/22 (27%)
		LRRCT	204..257	CDD:214507	14/58 (24%)
		Ig	259..364	CDD:299845	30/123 (24%)
		IG_like	266..362	CDD:214653	28/114 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	365..391		4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141335
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.800