DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and CG7896

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster

Alignment Length:	549	Identity:	119/549 - (21%)
Similarity:	190/549 - (34%)	Gaps:	185/549 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 QLLDLSGNEIQLIPDDSFATAQLL-NLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIP 176
            |.||:|.|..:::...:|...::| :|:..:|.:|  ..||::||::|.|||.|:...     :|
  Fly   935 QSLDVSNNSFEIVSQSNFGKLEMLRSLRLSHLPQC--TRIEKNAFKQLPNLVSLEAYD-----LP 992

  Fly   177 SLALYHVSELRELRLSGNPIL--RVPDDAFG--------HVPQLVKLELSDCRLSHIAVRAFAGL 231
            .|....:..:.|| |.|..:|  .|.|.:.|        | |:|..|.:...||..|:....|||
  Fly   993 LLGYLDLQGILEL-LPGLEVLDIEVKDSSIGSEQIQPLKH-PRLKSLGIRGDRLKSISSGTLAGL 1055

  Fly   232 ESSLEWLKLDGNRLS------------------EVRSGTITSL------------ASLHGLELAR 266
            :|:...::|....|:                  .|....||.|            |||....||.
  Fly  1056 KSNDLSVQLRNTSLNALPPALLFPVPRSSHLSLNVEGSKITVLVPQFLNALEDRRASLQLQGLAS 1120

  Fly   267 NTWNCSCSLRPLRAWMLQQNIPSGIPP-TCESPPRLSGRAWDKLDVDDFACVPQIVATDTTAHGV 330
            |...|.|:.|.||.|:..    ||:|. ||.||..|..|...::..|:..|
  Fly  1121 NPIVCDCNARALRRWLPS----SGMPDVTCASPAYLLNRKLIEVGDDELTC-------------- 1167

  Fly   331 EGRNITMSCYVEGVPQPAVKWLLKNRLIANLSAGGDGDSDSEPRTAAATQGRKTYVVNMLRNASN 395
            :.|.:|                               .|.|.| ||:        |.::|:.:|.
  Fly  1168 DARRMT-------------------------------SSTSRP-TAS--------VPHLLKTSSQ 1192

  Fly   396 LTILTADMQDAGIYTCAAE----NKAGKVEASVTLAVSRRPPEAPWGVRII-LLGAVAALLLVGG 455
            |...::...:..:...:.|    ....|::....|..::.|..:.....|| ::|.|.|.:.:
  Fly  1193 LVTRSSSTTEEPLIIWSLEPTQPPSLKKMKTKAPLMKAQSPIISNDDTLIIGIVGGVVAFIAI-- 1255

  Fly   456 SSFAAICLCSLQRRRKLRLWNSVPPVRRSESYEKIEMTARTRPDLGGGASCGGGSATGAGLFHDA 520
               ..|.:|.:    :||:.|:        .|::                    :||..|:
  Fly  1256 ---LIIIICII----RLRMSNA--------EYQQ--------------------NATMIGI---- 1281

  Fly   521 EEQGYLRAAHTPLND--NDAGQAAAIVNPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQP 583
             ..|....||....:  |.||.|...|.|                           .|.....:.
  Fly  1282 -PAGMQMGAHNAAYNYKNGAGAALYAVPP---------------------------YHATLPHKA 1318

  Fly   584 ASQHHPHPNQQQHQQRKGSQGHVVSASGA 612
            ||.|....|..|.||::..|..|.:|:.|
  Fly  1319 ASIHQSSQNLSQRQQQQQQQQQVAAAAAA 1347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	51/194 (26%)
		leucine-rich repeat	112..137	CDD:275380	7/24 (29%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	8/22 (36%)
		leucine-rich repeat	162..185	CDD:275380	5/22 (23%)
		LRR_8	184..245	CDD:290566	20/70 (29%)
		leucine-rich repeat	186..209	CDD:275380	9/32 (28%)
		leucine-rich repeat	210..234	CDD:275380	8/23 (35%)
		leucine-rich repeat	235..258	CDD:275380	6/52 (12%)
		LRRCT	267..316	CDD:214507	17/49 (35%)
		IG_like	328..428	CDD:214653	14/103 (14%)
		Ig	335..425	CDD:143165	12/93 (13%)
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		LRR_8	232..290	CDD:290566
		leucine-rich repeat	234..257	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		LRR_RI	273..535	CDD:238064
		LRR_8	281..338	CDD:290566
		leucine-rich repeat	282..329	CDD:275380
		LRR_8	328..388	CDD:290566
		leucine-rich repeat	330..353	CDD:275380
		leucine-rich repeat	354..377	CDD:275380
		leucine-rich repeat	378..401	CDD:275380
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	428..451	CDD:275380
		LRR_8	429..487	CDD:290566
		leucine-rich repeat	452..473	CDD:275380
		leucine-rich repeat	477..497	CDD:275378
		LRR_8	498..558	CDD:290566
		leucine-rich repeat	500..523	CDD:275380
		LRR_RI	502..769	CDD:238064
		leucine-rich repeat	524..547	CDD:275380
		leucine-rich repeat	548..571	CDD:275380
		LRR_8	572..630	CDD:290566
		leucine-rich repeat	572..595	CDD:275380
		leucine-rich repeat	596..619	CDD:275380
		LRR_8	619..678	CDD:290566
		leucine-rich repeat	620..643	CDD:275380
		leucine-rich repeat	644..667	CDD:275380
		LRR_8	666..726	CDD:290566
		leucine-rich repeat	668..691	CDD:275380
		leucine-rich repeat	692..715	CDD:275380
		LRR_8	714..774	CDD:290566
		leucine-rich repeat	716..739	CDD:275380
		leucine-rich repeat	740..761	CDD:275380
		leucine-rich repeat	764..789	CDD:275380
		leucine-rich repeat	790..810	CDD:275380
		leucine-rich repeat	818..850	CDD:275380
		leucine-rich repeat	863..883	CDD:275378
		LRR_RI	<878..1070	CDD:238064	41/143 (29%)
		LRR_8	884..944	CDD:290566	5/8 (63%)
		LRR_4	884..925	CDD:289563
		leucine-rich repeat	884..907	CDD:275380
		leucine-rich repeat	908..933	CDD:275380
		leucine-rich repeat	934..955	CDD:275380	6/19 (32%)
		leucine-rich repeat	958..982	CDD:275380	9/25 (36%)
		leucine-rich repeat	983..1055	CDD:275380	21/78 (27%)
		leucine-rich repeat	1009..1033	CDD:275380	5/24 (21%)
		leucine-rich repeat	1058..1085	CDD:275380	2/26 (8%)
		TPKR_C2	1121..1168	CDD:301599	18/64 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24366
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010