DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kek3 and MstProx

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_649719.2	Gene:	MstProx / 40890	FlyBaseID:	FBgn0015770	Length:	965	Species:	Drosophila melanogaster

Alignment Length:	357	Identity:	69/357 - (19%)
Similarity:	129/357 - (36%)	Gaps:	107/357 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 QLRAECPAVCECKWKSGKESVL----CLNANLTHIPQPLDAGTQLLDLSGNEIQLIPDDSFATAQ 134
            |:.|.||..|||.:  .::|::    |.|..:.:.|          |:.....:|:...:.::..
  Fly   512 QMAAPCPHKCECCY--SRDSLILKIDCRNKFVYNFP----------DIVARNSRLMGKQNMSSPM 564

  Fly   135 LLNLQKVYLARCHLRLIE---RHAFRKLINLVELDLSQNLLSAIPSLALYHVSELRELRLSGNP- 195
            .|:|.|..::...:.::.   |....:..|||.||  ..:||.:...::       :.:|||||
  Fly   565 ELHLSKNNISNITIAMLPKELRFLDLRFNNLVTLD--DKVLSYLKKNSI-------KTKLSGNPW 620

  Fly   196 --------ILRVPDDAFGHVPQLVKLELSDCRLS-------------HIAVRAF----------- 228
                    :|.:..|   |.|....:.|..|.:|             ::...:|
  Fly   621 NCDCKSRSVLSILRD---HEPLEYDVTLKRCNISPTDCPDVCVCCLDNLTWPSFIVDCRGEGLLQ 682

  Fly   229 -AGLESSLEWLKLDGNRLSEV----RSGTITSLASLHGLELARNTWNCSCSLRPLRAWMLQQNIP 288
             ..|.|.:.::.|..|.|:.:    ||........||.|:   |.|:|||:  .:......:::.
  Fly   683 MPSLSSRVTYVDLRNNNLTALSQKNRSSIENRSLKLHLLD---NPWSCSCN--DIEKINFMKSVS 742

  Fly   289 SGIPP----TCESPPRLSGRAWDKLDVDDFACVP-----------QIVATDTTAHGVEGRNITMS 338
            |.|..    .|.:..:|       :.::.....|           .:|||           |...
  Fly   743 SSIVDFTEIKCSNGEKL-------VSINQHIVCPSDLFYYLALAISLVAT-----------IIAL 789

  Fly   339 CYVEGVPQPAVKWLLKNRLIANLSAGGDGDSD 370
            .::....||.:.|..::.:..:|||..:.|.|
  Fly   790 NFLIWFRQPVLVWFYEHGVCLSLSAKRELDKD 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	36/197 (18%)
		leucine-rich repeat	112..137	CDD:275380	2/24 (8%)
		LRR_8	137..196	CDD:290566	15/70 (21%)
		leucine-rich repeat	138..161	CDD:275380	3/25 (12%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	17/94 (18%)
		leucine-rich repeat	186..209	CDD:275380	8/31 (26%)
		leucine-rich repeat	210..234	CDD:275380	5/48 (10%)
		leucine-rich repeat	235..258	CDD:275380	5/26 (19%)
		LRRCT	267..316	CDD:214507	9/52 (17%)
		IG_like	328..428	CDD:214653	9/43 (21%)
		Ig	335..425	CDD:143165	9/36 (25%)
MstProx	NP_649719.2	leucine-rich repeat	325..345	CDD:275378
		leucine-rich repeat	346..367	CDD:275378
		leucine-rich repeat	563..583	CDD:275378	3/19 (16%)
		leucine-rich repeat	585..610	CDD:275378	8/26 (31%)
		leucine-rich repeat	611..622	CDD:275378	5/17 (29%)
		TIR	823..960	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438697
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930