DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kek3 and ELFN1

DIOPT Version :9

Sequence 1:	NP_001162986.1	Gene:	kek3 / 34912	FlyBaseID:	FBgn0028370	Length:	1021	Species:	Drosophila melanogaster
Sequence 2:	NP_001122108.1	Gene:	ELFN1 / 392617	HGNCID:	33154	Length:	828	Species:	Homo sapiens

Alignment Length:	999	Identity:	197/999 - (19%)
Similarity:	312/999 - (31%)	Gaps:	334/999 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LWLLCCCSQL----GQLRAECPAVCECKW--KSGKESV---LCLNANLTHIPQPLDAGTQLLDLS 118
            ||:....:.|    |..||:|       |  :..|..|   :|......:...|....:.::||.
Human     9 LWVCVAAATLLHAGGLARADC-------WLIEGDKGFVWLAICSQNQPPYEAIPQQINSTIVDLR 66

  Fly   119 GNEIQLIPDDSFATAQLLNLQKVYLARCHLRLIERHAFRKLINLVELDLSQNLLSAIPSLALYHV 183
            .||.::......:.::..||..:.|.:..:..||..||....||..|.|..|.|..:....|..:
Human    67 LNENRIRSVQYASLSRFGNLTYLNLTKNEIGYIEDGAFSGQFNLQVLQLGYNRLRNLTEGMLRGL 131

  Fly   184 SELRELRLSGNPILRVPDDAFGHVPQLVKLELSDCRLSHIAVRAFAGLESSLEWLKLDGNRLSEV 248
            .:|..|.|..|.|..|...:|...|.:|.::||                         .||:.::
Human   132 GKLEYLYLQANLIEVVMASSFWECPNIVNIDLS-------------------------MNRIQQL 171

  Fly   249 RSGTITSLASLHGLELARNTWNCSCSLRPLRAWM------------LQQNIPSGIPPTCESPPRL 301
            .|||...||.|...||..|.:.|||.|.....|:            :|          |||||..
Human   172 NSGTFAGLAKLSVCELYSNPFYCSCELLGFLRWLAAFTNATQTYDRMQ----------CESPPVY 226

  Fly   302 SG------------RAWDKLDVDDFACVPQIVATDTTAHGVEGRNITMSCYVEGVPQPAVKWLLK 354
            ||            ....||         |.|.|:.          :.:..|.|.|:||     .
Human   227 SGYYLLGQGRRGHRSILSKL---------QSVCTED----------SYAAEVVGPPRPA-----S 267

  Fly   355 NRLIANLSA-------------------GGDGDSD--SEPRTAAATQGRKTYVVNML-RNASNLT 397
            .|.....|.                   .|||.:.  :.|..|...:.|....|..| :|::.:|
Human   268 GRSQPGRSPPPPPPPEPSDMPCADDECFSGDGTTPLVALPTLATQAEARPLIKVKQLTQNSATIT 332

  Fly   398 I-------------------------LTADMQDAGI--------YT-CAAENKAG--KVEASVTL 426
            :                         ||...::..:        || |.....||  .....:|:
Human   333 VQLPSPFHRMYTLEHFNNSKASTVSRLTKAQEEIRLTNLFTLTNYTYCVVSTSAGLRHNHTCLTI 397

  Fly   427 AVSRRP--------PEAPWGVRIILLGAVAALLLVGGSSFAAICLCSLQRRRKLRLWNSVPPVRR 483
            .:.|.|        |.......:.:||.:..::||.|    |:..|..:|||:............
Human   398 CLPRLPSPPGPVPSPSTATHYIMTILGCLFGMVLVLG----AVYYCLRRRRRQEEKHKKAASAAA 458

  Fly   484 SESYEKIEMTARTRPDL--GGGASCGGGSATGAGLFHDAEEQGYLRAAHTPLNDNDAGQAAAI-V 545
            :.|.:|..:..:..|:|  .|.|....|...|        .:...|..:.|.    ||:.... :
Human   459 AGSLKKTIIELKYGPELEAPGLAPLSQGPLLG--------PEAVTRIPYLPA----AGEVEQYKL 511

  Fly   546 NPSAGSAQRRNGDYLHVSTHCDDEEEDQQLHHHPQQQPASQHHPHPNQQQHQQRKGSQGHVVSAS 610
            ..||.:.:...|.|:.|.|....|..|.:|           ..|.|:.|              :|
Human   512 VESADTPKASKGSYMEVRTGDPPERRDCEL-----------GRPGPDSQ--------------SS 551

  Fly   611 GANNSAPLEETDLHIPRLIDIGGTDSASSSISSQVDAAARLAGYAGHTWKTTPIATTKINSPHSK 675
            .|..|...:|             .|..:..|::.:||...              .:|......|.
Human   552 VAEISTIAKE-------------VDKVNQIINNCIDALKS--------------ESTSFQGVKSG 589

  Fly   676 PVTSAAPSSLNTQATPYAHYGNHPADEMATSVFCSEGQESDLFDSNYPDLLDIAKYAVAQAQQEG 740
            ||:.|.|..:.......|.:|           |.:.|.: |.|..:            .|.....
Human   590 PVSVAEPPLVLLSEPLAAKHG-----------FLAPGYK-DAFGHS------------LQRHHSV 630

  Fly   741 RGQGYAQATTTPNGGLCTLPRKLKTSGKYFRNSSDSQSPLLADNSSKYGSSTLGDGSFLNEAMGL 805
            ...|..:|:|:.:|.:                    :||                .:|..||:|:
Human   631 EAAGPPRASTSSSGSV--------------------RSP----------------RAFRAEAVGV 659

  Fly   806 GRRYSAESSYANYSSTATYTGGGQRANSFLNLV--------------QSGAHQGKLLPSHLGQKP 856
            .:..:||:.|....|.|        |::.|.:.              |.|.|:.....||..:.|
Human   660 HKAAAAEAKYIEKGSPA--------ADAILTVTPAAAVLRAEAEKGRQYGEHRHSYPGSHPAEPP 716

  Fly   857 SLPS--SPVQHQ--RSLSSAATPL-------LDFSALASRAAGAANTSVAAYDYHAAQ--LERF- 907
            :.|.  .|..|:  ...:|...||       |.:|.|:.:....:.:|...|...|:|  .|||
Human   717 APPGPPPPPPHEGLGRKASILEPLTRPRPRDLAYSQLSPQYHSLSYSSSPEYTCRASQSIWERFR 781

  Fly   908 LEEYRNLQDQLCKMKETCDTIRKK 931
            |...|:.:::  :.......:|||
Human   782 LSRRRHKEEE--EFMAAGHALRKK 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kek3	NP_001162986.1	LRR_RI	<110..267	CDD:238064	39/156 (25%)
		leucine-rich repeat	112..137	CDD:275380	4/24 (17%)
		LRR_8	137..196	CDD:290566	18/58 (31%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	6/22 (27%)
		LRR_8	184..245	CDD:290566	12/60 (20%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..234	CDD:275380	3/23 (13%)
		leucine-rich repeat	235..258	CDD:275380	6/22 (27%)
		LRRCT	267..316	CDD:214507	16/72 (22%)
		IG_like	328..428	CDD:214653	25/157 (16%)
		Ig	335..425	CDD:143165	24/147 (16%)
ELFN1	NP_001122108.1	LRR 1	61..82		4/20 (20%)
		leucine-rich repeat	65..85	CDD:275378	3/19 (16%)
		LRR_8	85..144	CDD:404697	18/58 (31%)
		LRR 2	85..106		7/20 (35%)
		leucine-rich repeat	86..109	CDD:275378	6/22 (27%)
		LRR 3	109..130		7/20 (35%)
		leucine-rich repeat	110..133	CDD:275378	6/22 (27%)
		LRR 4	133..154		7/20 (35%)
		leucine-rich repeat	134..157	CDD:275378	7/22 (32%)
		LRR 5	157..178		8/45 (18%)
		leucine-rich repeat	158..171	CDD:275378	5/37 (14%)
		PCC	162..>256	CDD:188093	31/147 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..291		7/36 (19%)
		LRR 6	318..342		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	517..552		10/59 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..649		5/44 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	696..732		9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141306
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930